A controllable and degradable calcium phosphate bone cement and its preparation method

Abstract

The invention discloses a calcium phosphate bone cement degradable under regulation. The calcium phosphate bone cement is prepared from the following raw materials: a liquid-phase agent and a solid-phase powder. The liquid-phase agent is a common calcium phosphate bone cement liquid-phase agent or a mixed liquid of a two-dimensional black phosphorus nano-material dispersion liquid and the common calcium phosphate bone cement liquid-phase agent, wherein the two-dimensional black phosphorus nano-material dispersion liquid is a mixed liquid of a two-dimensional black phosphorus nano-material anddeionized water. The solid-phase powder is a mixture of a temperature-sensitive oxygen-produced compound and a calcium phosphate bone cement solid-phase powder, wherein the temperature-sensitive oxygen-produced compound is a sodium percarbonate-wax microsphere composite suface-coated with a gelatin layer, and the sodium percarbonate-wax microsphere composite is a sodium percarbonate microsphere composite coated with a wax layer. The invention also discloses a preparation method for the above-mentioned calcium phosphate bone cement degradable under regulation. The calcium phosphate bone cementprepared in the invention can be accelerated in degradation rate through both heat treatment and near-infrared light treatment, and is good in safety and suitable for mass production.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an adjustable and degradable calcium phosphate bone cement and a preparation method thereof. Background technique [0002] Calcium phosphate bone cement is a biomedical material that can not only help the repair and reconstruction of human hard tissues, but also serve as a carrier for drug release. Calcium phosphate bone cement has the advantages of easy preparation and arbitrary shaping. Compared with other bone cements, it has better biocompatibility, does not generate heat during solidification and crystallization, and has higher safety. However, the in vivo degradation rate of the existing calcium phosphate bone cement is relatively slow, which hinders the regeneration and reconstruction of human bone tissue to a certain extent, and it is impossible to realize the controllable degradation of calcium phosphate bone cement in vitro. At present, there a...

AI Technical Summary

Problems solved by technology

However, the degradation rate of the existing calcium phosphate bone cement in vivo is slow, which hinders the regeneration and reconstruction of human bone tissue to a certain extent, and it is impossible to realize the controllable degradation of calcium phosphate bone cement in vitro

At present, methods and products that can change the degradation rate of calcium phosphate cement in vitro through photothermal action have not been reported yet.

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