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Injectable self-cured calcium phosphate bone-rehabilitating material and its preparing process

A technology of calcium phosphate bone and repair material, which is applied in medical science, prosthesis, etc., can solve the problem that the injectability and stability of calcium phosphate paste need to be improved, cause complications, and the water resistance and collapse of calcium phosphate bone cement Insufficient sex and other problems to achieve the effect of improving the success rate of surgery and treatment effect, good fluidity and injectability, and good X-ray imaging effect

Active Publication Date: 2007-05-30
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] (1) The injectability and stability of calcium phosphate paste need to be improved
[0005] (2) Products with fast degradation rate have low strength; products with high strength have too slow degradation rate
[0006] (3) At present, the strength of calcium phosphate bone cement is between compact bone and cancellous bone, but it is still insufficient in clinical application, which limits its wide application [Y Fukase, "Setting reactions and compressive strengths of calcium phosphate cement" ( The setting reaction and compressive strength of calcium phosphate bone cement), Journal of Dental Research.1990; 69:1852~1856)]
[0007] (4) Injectable calcium phosphate bone cement is easy to leak during fixed-point injection, which brings pain to patients and may cause complications, which limits its popularization and application to a certain extent
However, M Bohner pointed out in the article "Technological issues for the development of more efficient calcium phosphate bone cements: A critical assessment" (Biomaterials2005: 26; 6423~6429) that these substances Poor biocompatibility, and it does not degrade itself, will not be degraded and absorbed, and will remain in the body as a foreign body for a long time, which may cause adverse effects on the human body
[0009] (5) Insufficient water resistance (also known as collapse resistance) of calcium phosphate bone cement
[0010] K Kurashina in "In vivo study of calcium phosphate cements: implantation of an alpha-tricalcium phosphate / dicalcium phosphate dibasic / tetracalcium phosphate monoxide cement paste" (Biomaterials, 1997; 18(7): 539 ~543) pointed out that when calcium phosphate bone cement is used in the repair of bone defects in animals, the calcium phosphate bone cement will be washed away by uncontrollable bleeding in the operation area, resulting in the loss of calcium phosphate bone cement

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The injectable self-curing calcium phosphate bone repair material of the present invention is composed of a solid phase and a liquid phase. Firstly, its raw material source is as follows: Carbonated high-activity partially crystalline calcium phosphate powder according to the Chinese invention patent "Carbonated high-activity partially crystalline phosphoric acid Calcium and its preparation method” (Application No.: 200510037549.9) disclosed process preparation, its particle size is less than 50 μm; β-dicalcium silicate powder is prepared by sol-gel method, its particle size is less than 50 μm; Description of the Chinese invention patent "Method for Improving Collapse Resistance of Calcium Phosphate Bone Cement Using Modified Starch" (Application No.: 200510100471.0); degradable polymer microspheres and microcapsules are prepared by microemulsion method or spray drying method; the rest of the compounds are Commercially available, its particle size is less than 50 μm. Th...

Embodiment 2

[0036] The source of raw materials is the same as in Example 1. Weigh 6g of carbonated high-activity partially crystalline calcium phosphate powder, 4g of calcium hydrogen phosphate dihydrate powder, 2g of modified starch, and 1.5g of β-dicalcium silicate powder, and mix them evenly with 16ml of 10g / mL sodium phosphate solution, An injectable self-curing calcium phosphate bone repair material was prepared.

Embodiment 3

[0038] The source of raw materials is the same as in Example 1. Weigh 5g of carbonated high-activity partially crystalline calcium phosphate powder, 5g of anhydrous calcium hydrogen phosphate powder, 0.5g of modified starch, 0.5g of strontium fluoride powder, 0.5g of bismuth phosphate powder, and use 5g / mL of hydrogen phosphate 7ml of disodium solution was evenly mixed to prepare an injectable self-curing calcium phosphate bone repair material.

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Abstract

The invention discloses an injectable self-solidifying calcium phosphate bone-repairing material and making method, which consists of solid phase and liquid phase, wherein the solid phase contains 0.2-2.0% degeneration starch, 0-15% beta-dicalcium silicate powder, 0-15% strontium and bismuth compound and 0-30% macromolecular microball or microcapsule; the liquid phase is composed of one or more composition of deionized water, diluted phosphoric acid, physiological saline, blood, soluble phosphate solution and organic acid; the rate of liquid phase and solid phase is 0.3-1.2ml / g.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to an injectable self-curing calcium phosphate bone repair material for human hard tissue repair and a preparation method thereof. Background technique [0002] The treatment of fractures, osteoporosis and bone defects requires a large amount of bone repair materials. Scientists from all over the world are working hard to improve and research existing bone graft materials, as well as develop new bone repair materials. Injectable calcium phosphate bone cement is currently the only resorbable bone repair material that can solidify itself and produce bone regeneration effects. It has achieved the unity of high biocompatibility and arbitrary shape, and has been recognized by the international biomaterials community It has become one of the research hotspots of biomaterials today and has been gradually applied in clinical practice. [0003] Foreign countries ...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/40
Inventor 叶建东王秀鹏王迎军陈玲
Owner SOUTH CHINA UNIV OF TECH
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