Injectable self-cured calcium phosphate bone-rehabilitating material and its preparing process

Abstract

The invention discloses an injectable self-curing calcium phosphate bone repair material and a preparation method thereof. The material is composed of a solid phase and a liquid phase. The solid phase is calculated by 100 parts by mass of polybasic calcium phosphate salt, and 0.2-2.0 parts by mass of modified starch. 0-15 parts by mass of β-dicalcium silicate powder, 0-15 parts by mass of strontium and bismuth compounds, 0-30 parts by mass of polymer microspheres or microcapsules; deionized water, dilute phosphoric acid, and normal saline are used as the liquid phase , blood, soluble phosphate solution, organic acid or a mixture of more than one; according to the ratio of liquid phase to solid phase: 0.3 ~ 1.2ml / g evenly reconciled. This material has good comprehensive performance and can meet the requirements of clinical application, and is suitable for bone defect repair, osteoporosis treatment and fracture fixation and treatment in orthopedics, spine surgery, plastic surgery and stomatology.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to an injectable self-curing calcium phosphate bone repair material for human hard tissue repair and a preparation method thereof. Background technique [0002] The treatment of fractures, osteoporosis and bone defects requires a large amount of bone repair materials. Scientists from all over the world are working hard to improve and research existing bone graft materials, as well as develop new bone repair materials. Injectable calcium phosphate bone cement is currently the only resorbable bone repair material that can solidify itself and produce bone regeneration effects. It has become one of the research hotspots of biomaterials today and has been gradually applied in clinical practice. [0003] Foreign countries began to study injectable self-curing bone substitute materials in the mid-1990s. A variety of injectable self-curing calcium phosphate bone substitutes with differe...

AI Technical Summary

Problems solved by technology

[0004] (1) The injectability and stability of calcium phosphate paste need to be improved

[0005] (2) Products with fast degradation rate have low strength; products with high strength have too slow degradation rate

[0006] (3) At present, the strength of calcium phosphate bone cement is between compact bone and cancellous bone, but it is still insufficient in clinical application, which limits its wide application [Y Fukase, "Setting reactions and compressive strengths of calcium phosphate cement" ( The setting reaction and compressive strength of calcium phosphate bone cement), Journal of Dental Research.1990; 69:1852~1856)]

[0007] (4) Injectable calcium phosphate bone cement is easy to leak during fixed-point injection, which brings pain to patients and may cause complications, which limits its popularization and application to a certain extent

However, M Bohner pointed out in the article "Technological issues for the development of more efficient calcium phosphate bone cements: A critical assessment" (Biomaterials2005: 26; 6423~6429) that these substances Poor biocompatibility, and it does not degrade itself, will not be degraded and absorbed, and will remain in the body as a foreign body for a long time, which may cause adverse effects on the human body

[0009] (5) Insufficient water resistance (also known as collapse resistance) of calcium phosphate bone cement

[0010] K Kurashina in "In vivo study of calcium phosphate cements: implantation of an alpha-tricalcium phosphate / dicalcium phosphate dibasic / tetracalcium phosphate monoxide cement paste" (Biomaterials, 1997; 18(7): 539 ~543) pointed out that when calcium phosphate bone cement is used in the repair of bone defects in animals, the calcium phosphate bone cement will be washed away by uncontrollable bleeding in the operation area, resulting in the loss of calcium phosphate bone cement