Preparation method of brushite bone cement

A technology of brushite and bone cement, applied in medical science, prosthesis, etc., can solve the problems of prolonged curing time, achieve the effects of prolonging curing time, improving injectability, and simple preparation method

Inactive Publication Date: 2015-02-25
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, gelatin will also lead to prolonged curing time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0025] Preparation of phosphorylated chitosan:

[0026] 1. Dissolve 10 grams of chitosan in 500 mL of 1% acetic acid aqueous solution, then heat to 70 degrees. The chitosan includes commercial or non-commercial chitosans of different molecular weights and molecular weight distributions.

[0027] 2. Add 10 grams of concentrated phosphoric acid to the chitosan solution at 70 degrees.

[0028] 3. Add 52 mL of formaldehyde solution and continue the reaction for 2 hours before stopping the reaction.

[0029] 4. Precipitate the solution in ethanol and dry to obtain phosphorylated chitosan.

Embodiment 1

[0031] Take by weighing 0.2g phosphorylated chitosan, 0.2g gelatin, 0.2g hydroxypropyl methylcellulose, dissolve in 19.4g 20wt% citric acid aqueous solution, prepare 20% citric acid, 1% phosphorylated chitosan, 1% gelatin, 1% hydroxypropyl methylcellulose bone cement solidification solution. β-tricalcium phosphate and calcium dihydrogen phosphate monohydrate were mixed at a ratio of 70:30, and the bone cement powder and solidification solution were mixed at a solid-liquid ratio of 1.5g / mL. The initial setting time was determined to be 10 minutes according to the standard ASTM C191 , Its injectability is good, and solid-liquid separation does not occur under a certain pressure.

Embodiment 2

[0033] Weigh 0.2g gelatin, 0.2g hydroxypropyl methylcellulose, dissolve in 19.6g 10wt% citric acid aqueous solution, prepare 20% citric acid, 1% phosphorylated chitosan, 1% gelatin, 1% hydroxypropyl methylcellulose Bone cement solidification solution of methyl cellulose. β-tricalcium phosphate and calcium dihydrogen phosphate monohydrate were mixed at a ratio of 70:30, and the bone cement powder and solidified liquid were mixed at a solid-liquid ratio of 1.5g / mL. The initial setting time was determined to be 6 minutes according to the standard ASTM C191. The blended pulp has good fluidity, and slight solid-liquid separation occurs under a certain pressure.

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Abstract

The invention relates to a preparation method of brushite bone cement. The preparation method comprises the following steps: preparing an acidic bone cement solidification liquid by adopting a citric acid solution as a main body and adopting phosphorylated chitosan, hydroxypropyl methyl cellulose and gelatin as modifying agents; fully mixing monohydrate calcium dihydrogen phosphate, beta-tricalcium phosphate and SiO2 to obtain SiO2 modified brushite bone cement solid-phase powder; and mixing the bone cement solid-phase powder with the solidification liquid according to a solid-to-liquid ratio to obtain the brushite bone cement, wherein a solidification product comprises brushite as a main component. By adopting the preparation method disclosed by the invention, the solidification time of the brushite bone cement which adopts a conventional citric acid solution as the solidification liquid can be prolonged to be 6-20 minutes, and the flowability of blended slurry can be increased; and meanwhile, by virtue of complexing action of phosphorylated chitosan, solid-liquid separation of the blended slurry at a certain pressure can be avoided, and the comprehensive performance of the blended slurry can preferably meet the requirements of clinical application.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to a method for brushite bone cement. Background technique [0002] Brushite bone cement has better biodegradability in vivo, but its clinical application is limited due to the short curing time (usually within 1 min) and poor injectability. The main component of brushite bone cement is calcium hydrogen phosphate dihydrate (DCPD), which is formed by the acid-base neutralization reaction of two or more calcium phosphate salts in an acidic environment. nuclear process. Citric acid solution is a common acidic curing solution, and a single citric acid solution cannot meet the comprehensive performance of bone cement, and one or more additives usually need to be added to it. [0003] Chitosan and its derivatives have attracted extensive attention because of their good biocompatibility, biodegradability, and obvious enhancement effect on bone cement. Phosphoryl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/22A61L27/12
Inventor 何丹农杨迪诚钟建
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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