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Doped black phosphorus quantum dot thermal treatment syringeability bone cement as well as preparation and application thereof

A technology of quantum dots and bone cement, which is applied in the fields of preparation and application of injectable bone cement for thermal treatment of quantum dots doped with black phosphorus, can solve problems such as inability to degrade, and achieves improved biocompatibility, simple raw materials, and adaptability. effect on mass production

Inactive Publication Date: 2017-05-17
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the currently commonly used inorganic nano-photothermal conversion materials are often not degradable in the body, but persist in the organ for a long time in the form of nanoparticles.

Method used

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  • Doped black phosphorus quantum dot thermal treatment syringeability bone cement as well as preparation and application thereof
  • Doped black phosphorus quantum dot thermal treatment syringeability bone cement as well as preparation and application thereof
  • Doped black phosphorus quantum dot thermal treatment syringeability bone cement as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Disperse alpha-tricalcium phosphate in absolute ethanol to form a 40g / L solution, mix at 400rpm for liquid phase grinding for 4h, then add 10000:1 PLGA / black phosphorus quantum dots to the solution, and then add 0.5% The gelatin was further milled in a ball mill for 15 minutes, and the resulting solution was rotovapped to obtain a powder. Among them, alpha-tricalcium phosphate: PLGA / black phosphorus quantum dots=10000:1

[0035] Take by weighing 0.1g phosphorylated chitosan, 0.15g gelatin, 0.1g hydroxypropyl methylcellulose, dissolve in 19.65g sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan, 1.5% gelatin, 1% hydroxypropyl methylcellulose bone cement solidification solution.

[0036]The bone cement powder and curing liquid were mixed at a solid-liquid ratio of 2-2.5 g / mL, and the initial setting time was determined to be 12 min by referring to the standard ASTM C191.

Embodiment 2

[0038] Disperse alpha-tricalcium phosphate in absolute ethanol to form a 40g / L solution, mix at 400rpm for liquid phase grinding for 4h, then add 5000:1 PLGA / black phosphorus quantum dots to the solution, and then add 0.5% The gelatin was further milled in a ball mill for 15 minutes, and the resulting solution was rotovapped to obtain a powder. Among them, alpha-tricalcium phosphate: PLGA / black phosphorus quantum dots=5000:1

[0039] Take by weighing 0.1g phosphorylated chitosan, 0.15g gelatin, 0.1g hydroxypropyl methylcellulose, dissolve in 19.65g sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan, 1.5% gelatin, 1% hydroxypropyl methylcellulose bone cement solidification solution.

[0040] The bone cement powder and curing liquid were mixed at a solid-liquid ratio of 2-2.5 g / mL, and the initial setting time was determined to be 13 min by referring to the standard ASTM C191.

Embodiment 3

[0042] Disperse alpha-tricalcium phosphate in absolute ethanol to form a 40g / L solution, mix at 400rpm for liquid phase grinding for 4h, then add 2000:1 PLGA / black phosphorus quantum dots to the solution, and then add 0.5% The gelatin was further milled in a ball mill for 15 minutes, and the resulting solution was rotovapped to obtain a powder. Among them, alpha-tricalcium phosphate: PLGA / black phosphorus quantum dots=2000:1

[0043] Take by weighing 0.1g phosphorylated chitosan, 0.15g gelatin, 0.1g hydroxypropyl methylcellulose, dissolve in 19.65g sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan, 1.5% gelatin, 1% hydroxypropyl methylcellulose bone cement solidification solution.

[0044] The bone cement powder and curing liquid were mixed at a solid-to-liquid ratio of 2-2.5 g / mL, and the initial setting time was determined to be 15 min by referring to the standard ASTM C191.

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Abstract

The invention relates to doped black phosphorus quantum dot thermal treatment syringeability bone cement as well as the preparation and the application thereof. A self-cured component is mixed with a heating nano material so as to obtain a modified bone cement solid-phase powder, wherein an alpha-tricalcium phosphate material functions as coating and carrying, and PLGA (Plgapoly Lactic-Co-Glycolic Acid) / black phosphorus quantum dots function as heating; by taking sodium phosphate as a main body and phosphorylated chitosan, hydroxypropyl methyl cellulose and gelatin as modifiers, preparing a neutral bone cement curing liquid so as to improve the syringeability of a formula; mixing the bone cement solid-phase powder with the curing liquid, so as to obtain a cured product. A main component, namely, hydroxyapatite, of the cured product, can be increased, and the PLGA and a black phosphorus material have very good degradation properties inside biological bodies. The doped black phosphorus quantum dot thermal treatment syringeability bone cement has the advantages of being simple and convenient in preparation method, simple in raw material and applicable to large-scale production.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to an injectable bone cement doped with black phosphorus quantum dots for thermal treatment and its preparation and application. [0002] technical background [0003] Bone tumor (bone tumor) is a tumor that occurs in the bone or its subsidiary tissues (vascular, nerve, bone marrow, etc.), and is a common disease. Like other tissues in the body, its exact cause is unknown. Bone tumors can be divided into benign and malignant. Benign bone tumors are easy to cure and have a good prognosis. Malignant bone tumors develop rapidly, have poor prognosis and high mortality. So far, there is no satisfactory treatment. Malignant bone tumors can be primary or secondary. Malignant tumors in other tissues or organs in the body are transferred to bones through blood circulation and lymphatic system or directly invade bones. Bone tumors or tumor-like lesions are mainly sur...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/12A61L27/20A61L27/22A61L27/18
CPCA61L27/50A61L27/12A61L27/18A61L27/20A61L27/222A61L2400/06A61L2430/02C08L89/00C08L5/08C08L1/284C08L67/04
Inventor 何丹农严一楠杨迪诚王萍李士浩金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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