Doped black phosphorus quantum dot thermal treatment syringeability bone cement as well as preparation and application thereof
A technology of quantum dots and bone cement, which is applied in the fields of preparation and application of injectable bone cement for thermal treatment of quantum dots doped with black phosphorus, can solve problems such as inability to degrade, and achieves improved biocompatibility, simple raw materials, and adaptability. effect on mass production
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Embodiment 1
[0034] Disperse alpha-tricalcium phosphate in absolute ethanol to form a 40g / L solution, mix at 400rpm for liquid phase grinding for 4h, then add 10000:1 PLGA / black phosphorus quantum dots to the solution, and then add 0.5% The gelatin was further milled in a ball mill for 15 minutes, and the resulting solution was rotovapped to obtain a powder. Among them, alpha-tricalcium phosphate: PLGA / black phosphorus quantum dots=10000:1
[0035] Take by weighing 0.1g phosphorylated chitosan, 0.15g gelatin, 0.1g hydroxypropyl methylcellulose, dissolve in 19.65g sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan, 1.5% gelatin, 1% hydroxypropyl methylcellulose bone cement solidification solution.
[0036]The bone cement powder and curing liquid were mixed at a solid-liquid ratio of 2-2.5 g / mL, and the initial setting time was determined to be 12 min by referring to the standard ASTM C191.
Embodiment 2
[0038] Disperse alpha-tricalcium phosphate in absolute ethanol to form a 40g / L solution, mix at 400rpm for liquid phase grinding for 4h, then add 5000:1 PLGA / black phosphorus quantum dots to the solution, and then add 0.5% The gelatin was further milled in a ball mill for 15 minutes, and the resulting solution was rotovapped to obtain a powder. Among them, alpha-tricalcium phosphate: PLGA / black phosphorus quantum dots=5000:1
[0039] Take by weighing 0.1g phosphorylated chitosan, 0.15g gelatin, 0.1g hydroxypropyl methylcellulose, dissolve in 19.65g sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan, 1.5% gelatin, 1% hydroxypropyl methylcellulose bone cement solidification solution.
[0040] The bone cement powder and curing liquid were mixed at a solid-liquid ratio of 2-2.5 g / mL, and the initial setting time was determined to be 13 min by referring to the standard ASTM C191.
Embodiment 3
[0042] Disperse alpha-tricalcium phosphate in absolute ethanol to form a 40g / L solution, mix at 400rpm for liquid phase grinding for 4h, then add 2000:1 PLGA / black phosphorus quantum dots to the solution, and then add 0.5% The gelatin was further milled in a ball mill for 15 minutes, and the resulting solution was rotovapped to obtain a powder. Among them, alpha-tricalcium phosphate: PLGA / black phosphorus quantum dots=2000:1
[0043] Take by weighing 0.1g phosphorylated chitosan, 0.15g gelatin, 0.1g hydroxypropyl methylcellulose, dissolve in 19.65g sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan, 1.5% gelatin, 1% hydroxypropyl methylcellulose bone cement solidification solution.
[0044] The bone cement powder and curing liquid were mixed at a solid-to-liquid ratio of 2-2.5 g / mL, and the initial setting time was determined to be 15 min by referring to the standard ASTM C191.
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