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Preparation method of drug-loaded bone growth-promoting injectable calcium sulfate bone cement

A technology of bone cement and calcium sulfate, which is applied in the field of biomedical material technology, can solve problems such as prolonged curing time, and achieve the effects of improved injectability, simple raw materials, and convenient preparation methods

Active Publication Date: 2018-07-17
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, gelatin will also lead to prolonged curing time

Method used

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  • Preparation method of drug-loaded bone growth-promoting injectable calcium sulfate bone cement
  • Preparation method of drug-loaded bone growth-promoting injectable calcium sulfate bone cement
  • Preparation method of drug-loaded bone growth-promoting injectable calcium sulfate bone cement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Sodium alendronate was pre-dissolved in absolute ethanol solution to form a 0.1Mol / L solution, and then homemade hydroxyapatite powder was added to the solution, mixed in a ball mill for liquid-phase grinding surface modification, and rotary evaporation Powder after solvent.

[0038] Pre-dissolve vancomycin in absolute ethanol solution to form a 0.1Mol / L solution, then add self-made β-tricalcium phosphate powder into the solution, mix in a ball mill for liquid phase grinding surface modification, and rotate the solvent to evaporate Then get powder. Use the above as a recipe alternative.

[0039] Take by weighing 0.1g phosphorylated chitosan, 0.15g gelatin, 0.1g hydroxypropyl methylcellulose, dissolve in 19.65g sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan, 1.5% gelatin, 1% hydroxypropyl methylcellulose bone cement solidification solution.

[0040] Pure calcium sulfate hemihydrate is a solid phase powder. The bon...

Embodiment 2

[0042] Sodium alendronate was pre-dissolved in absolute ethanol solution to form a 0.1Mol / L solution, and then homemade hydroxyapatite powder was added to the solution, mixed in a ball mill for liquid-phase grinding surface modification, and rotary evaporation Powder after solvent.

[0043] Pre-dissolve vancomycin in absolute ethanol solution to form a 0.1Mol / L solution, then add self-made β-tricalcium phosphate powder into the solution, mix in a ball mill for liquid phase grinding surface modification, and rotate the solvent to evaporate Then get powder.

[0044] Calcium sulfate hemihydrate, β-tricalcium phosphate and hydroxyapatite were mixed at a ratio of 5:4:1 to prepare bone cement solid phase powder.

[0045] Take by weighing 0.1g phosphorylated chitosan, 0.15g gelatin, 0.1g hydroxypropyl methylcellulose, dissolve in 19.65g sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan, 1.5% gelatin, 1% hydroxypropyl methylcellulo...

Embodiment 3

[0048] Sodium alendronate was pre-dissolved in absolute ethanol solution to form a 0.1Mol / L solution, and then homemade hydroxyapatite powder was added to the solution, mixed in a ball mill for liquid-phase grinding surface modification, and rotary evaporation Powder after solvent.

[0049] Pre-dissolve vancomycin in absolute ethanol solution to form a 0.1Mol / L solution, then add self-made β-tricalcium phosphate powder into the solution, mix in a ball mill for liquid phase grinding surface modification, and rotate the solvent to evaporate Then get powder.

[0050] Calcium sulfate hemihydrate, β-tricalcium phosphate and hydroxyapatite were mixed in a ratio of 5:3:2 to prepare bone cement solid phase powder.

[0051] Take by weighing 0.1g phosphorylated chitosan, 0.15g gelatin, 0.1g hydroxypropyl methylcellulose, dissolve in 19.65g sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan, 1.5% gelatin, 1% hydroxypropyl methylcellulo...

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Abstract

The invention provides a method for preparing drug-loaded injection type calcium sulfate bone cement for promoting bone growth. The method comprises the following steps: mixing calcium sulfate hemihydrate, drug-loaded beta-tricalcium phosphate and hydroxyapatite to obtain modified calcium carbonate bone cement solid phase powder, and preparing a neutral bone cement curing liquid by using sodium phosphate as a main body and phosphorylated chitosan, hydroxypropyl methyl cellulose and gelatin as modifying agents to improve the injectable property of the formula; and mixing the bone cement solid phase powder with the curing liquid, and adding main ingredients of a curing product, namely brushite and hydroxyapatite which have better degrading capability in an organism. The drug-loaded injection type calcium sulfate bone cement is simple in raw materials and easy in preparation process, and can be used for large-scale production. The formula of the bone cement has a remarkable effect for improving the curing time and injection property of the calcium sulfate bone cement, has a drug-loading function, and has a wide application prospect in the field of clinical tissue repairing.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, specifically, the particle size of the self-made calcium sulfate hydrate is 200-2000nm, the particle size of the β-tricalcium phosphate is 15-100nm, and the particle size of hydroxyapatite is The diameter is 100-1000nm as the main component, adding antibiotics such as sodium alendronate and vancomycin, as a neutral injectable bone cement powder. The solidification solution is neutral sodium hydrogen phosphate solution or sodium chloride, in which phosphorylated chitosan, gelatin and other components are added to improve the fluidity of bone cement, and construct a new porous bone cement repair system that promotes the proliferation and growth of bone structure. Background technique [0002] In my country, there are as many as 3 million patients with bone defects caused by traffic accidents and work-related injuries each year that require transplantation. This increases th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58A61L27/54A61L27/12A61L27/04A61L27/20A61L27/22
Inventor 何丹农严一楠刘训伟姜杰王萍周涓
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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