9 results about "Trimethylsilanol" patented technology

The invention provides a preparation method and application of a long-acting insulin analogue, and the preparation method comprises the following steps: taking eicosandioic acid A as a starting raw material, carrying out unilateral esterification with trimethylsilyl ethanol to obtain an intermediate B, reacting the intermediate B with Hosu to obtain an active intermediate C, reacting the intermediate C with L-glutamic acid-1-trimethylsilyl ethyl ester to obtain an intermediate D, and carrying out condensation reaction on the intermediate D to obtain the long-acting insulin analogue. The intermediate D reacts with Hosu to obtain an active intermediate E, the intermediate E reacts with AEEA-AEA to obtain an intermediate F, the intermediate F reacts with Hosu to obtain an active intermediate G, and trimethylsilylethyl is removed from the intermediate G through tetrabutylammonium fluoride trihydrate to obtain the Ecobainsulin side chain. The route of the method has the following advantages that related raw materials are simple and easy to obtain, the reaction condition is mild, the yield is high, and the method is suitable for industrial production. The preparation method is simple and easy to implement, large-scale production is easy, the prepared side chain of the Ekoinsulin and A14E, B16E, B25H and DesB30 insulin precursors are coupled with lysine at the B29 site under the alkaline condition to obtain a crude Ekoinsulin product, and the crude product is subjected to two-step purification to obtain the Ekoinsulin with the purity of 99.0% or above.

The invention discloses excellent-reliability silicone rubber for an airbag coating and a preparation method and application thereof.The excellent-reliability silicone rubber is composed of a component A and a component B. Raw materials of the component A comprise a basic rubber material, a cross-linking agent, a coupling agent and an inhibitor; and the component B comprises the following raw materials: a basic rubber material, a platinum catalyst and titanate. According to the invention, a treating agent is added into a basic rubber material to obtain the silicone rubber for the airbag coating, which has good adhesion to airbag base material cloth PA and PET, wherein the treating agent is one or a mixture of more of trimethylsilanol, hydroxyl silicone oil, vinyl hydroxyl silicone oil and hexamethyldisilazane; and the silicone rubber for the airbag coating has good adhesion to the airbag base material cloth PA and PET, and the treating agent is one or a mixture of more of trimethylsilanol, hydroxyl silicone oil, vinyl hydroxyl silicone oil and hexamethyldisilazane. According to the invention, excellent reliability of the safety airbag base material cloth PA and PET is realized by using a specific process (two-stage treatment process). According to the silicone rubber for the airbag coating prepared by the invention, the silicone resin is treated by the treating agent, so that the Si-OH content in the silicone resin is reduced, and the aging reliability of the liquid silicone rubber coating is improved.

The invention provides a 1, 2, 4-oxadiazole biphenyl compound as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention provides a 1, 2, 4-oxadiazole biphenyl compound which has a structure as shown in a formula h. By introducing dioxin, amide bridges and chlorine atoms, the water solubility of the compound can be improved. In addition, potassium trimethylsilanolate is used as an alkali reagent of an SZUKI coupling reaction, methylbenzene is used for replacing trichloroacetic anhydride to serve as a solvent of a cyclization reaction, and a mixed solvent of dichloromethane and methanol is used as a reaction solvent of reductive amination to optimize the reaction. When the 1, 2, 4-oxadiazole biphenyl compound provided by the invention is used as a PD-L1 small-molecule inhibitor, the 1, 2, 4-oxadiazole biphenyl compound has good targeting property and anti-proliferative activity, and a basis is provided for further enriching a small-molecule inhibitor compound library and researching the structure-function relationship of the 1, 2, 4-oxadiazole inhibitor.

The application discloses a synthesis method of hexa-substituted oxy-cyclotriphosphazene compounds, under nitrogen condition, crystallized hexachlorocyclotriphosphazene is dissolved in a solvent, and then is added into a solution of one or two of phenol / 4-nitrophenol / trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthioether phenol, and then potassium trimethylsilanol is added, and reaction is carried out at 65-100 DEG C for 6-24 h; after the reaction is completed, corresponding hexa-substituted oxy-cyclotriphosphazene derivatives are obtained through post-treatment. The application selects a solvent with high safety and low toxicity and high-activity potassium trimethylsilanol to realize the synthesis of phenol and alkyl alcohol hexa-substituted oxy-cyclotriphosphazene; and through optimization of the post-treatment method, the residual phenol and salt in the reaction system can be efficiently removed, and the waste water and waste liquid generated due to post-treatment are greatly reduced.

This invention provides a method for preparing a flexible solid-state dry electrode sheet. The method first mixes polytetrafluoroethylene (PTFE) with lithium trimethylsilanolate to obtain a first powder; then, an electrode active material and a conductive agent are added to the first powder and mixed to obtain a second powder; the second powder is then hot-rolled into a film and thinned by rolling to form an electrode film; finally, the electrode film is hot-pressed onto a current collector to obtain the flexible solid-state dry electrode sheet. This method modifies PTFE by adding lithium trimethylsilanolate, improving the adhesion of the binder and increasing mechanical strength. By controlling the amount of lithium trimethylsilanolate and PTFE, this invention results in an electrode sheet with good mechanical properties and viscoelasticity; furthermore, the adhesion of lithium trimethylsilanolate to the fiber surface provides a lithium-ion pathway, thereby increasing ionic conductivity.

The present application relates to a kind of 2-amino-3-phenyl-2-methyl butyric acid compound synthesis method, comprising the following steps: (1) N-(benzyl) alanine is reacted with benzaldehyde, and 3-benzyl-4-methyl-2-phenyl oxazolidine-5-ketone is generated;(2) 3-benzyl-4-methyl-2-phenyl oxazolidine-5-ketone is reacted with the compound shown in formula (II) under the action of catalyst to generate the compound shown in formula (III);(3) the compound shown in formula (III) is reacted with potassium trimethylsilanol, and the compound shown in formula (I) is generated, i.e. the 2-amino-3-phenyl-2-methyl butyric acid compound.The synthesis method of the present application fills the blank of the synthesis method of 2-amino-3-phenyl-2-methyl butyric acid compound, and the yield of the synthesis method of the present application is high, and it is suitable for industrial production.

This invention provides a comprehensive method for preparing vinyl sulfate and the vinyl sulfate obtained therefrom. The method includes: mixing bis(trimethylsilyl)sulfate, alkyl diol, a metal halide catalyst, and a first solvent; performing a first reaction to obtain catalyst residue, trimethylsilanol, and vinyl sulfate; and then reacting the catalyst residue with trimethylsilanol to recover hexamethyldisiloxane, which is used as a raw material for preparing bis(trimethylsilyl)sulfate. This comprehensive method provides vinyl sulfate, and the catalyst can be used in two ways, generating the byproduct hexamethyldisiloxane, which can be recycled and used as a raw material to react with sulfuric acid to prepare bis(trimethylsilyl)sulfate. This achieves material recycling, significantly reduces economic costs, greatly improves atom economy and the greenness of the process, and has certain feasibility in industrial production.

The invention relates to the technical field of radiopharmaceuticals, in particular to application of an unterminated C18 small column in preparation of fluorine-18 labeled deoxyglucose. According to the invention, an unterminated C18 small column comprises an unterminated C18 filler and an SEP small column shell; wherein an inner cavity of the SEP small column shell is filled and compacted with the unsealed C18 filler; the unterminated C18 filler is an octadecyl silane bonded silica gel filler which is not subjected to end capping treatment. According to the method disclosed by the invention, when the fluorine-18-labeled deoxyglucose is prepared by utilizing the unterminated C18 small column, the impurity, namely trimethyl silanol, can be removed from the aspect of a process under the condition that the synthesis yield of the fluorine-18-labeled deoxyglucose (18F-FDG) is not reduced.