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Novel gold nanoparticle aggregates and their applications

a technology of nanoparticles and aggregates, applied in the field of new gold nanoparticle aggregates and their applications, can solve the problems that no one perceived that raman fibers could be pumped, and achieve the effect of convenient use and low manufacturing cos

Inactive Publication Date: 2008-07-10
UNIV OF SOUTH FLORIDA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0038]The invention also provides a method for creating a chemical sensor with improved sensitivity, the method comprising the steps of: (i) providing the chemical sensing particle comprising gold nanoparticle aggregates as disclosed above; (ii) illuminating the gold nanoparticle aggregates with an amplified femtosecond beam at a flux of approximately 0.1 mJ / cm2 for 1 hour; (iii) illuminating the gold nanoparticle aggregates using a tunable picosecond laser, thereby creating a chemical sensor with improved sensitivity.

Problems solved by technology

In the early years of the Raman fiber before extensive work had begun, no one perceived that a Raman fiber could be pumped by a practical semiconductor laser-based source or that an efficient CW-pumped Raman Fiber Laser was possible.

Method used

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Examples

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examples

[0126]The invention will be more readily understood by reference to the following examples, which are included merely for purposes of illustration of certain aspects and embodiments of the present invention and not as limitations.

example i

Synthesis of Gold Nanoparticle Aggregates

[0127]The synthesis of the gold nanoparticle aggregates (GNAs) was performed as follows: 400-600 ul of a 0.02 M HAuCl4 stock solution was diluted to 4×10−4-6×10−4 M with Milli-Q water in glassware cleaned in aquaregia and rinsed with Milli-Q water to avoid contamination. To this, 40-60 μl of a 0.1 M solution of Na2S that has been aged for 2-3 months was added. After approximately 60-120 minutes, the color changed from a straw yellow to deep purple with the extended plasmon band (EPB) growing in between 600-1000 nm, indicating reaction completion. The aggregate formation was signified by strong near-infra-red (NIR) absorption at wavelengths longer than 600 nm. This reaction is also performed with sodium thiosulfate (Na2S2O3) by replacing 1:1 the sodium sulfide solution, however, while these particles are optically identical to those that are sodium sulfide generated, they work poorly for SERS and should only be used for non detection applicati...

example ii

Coating Gold Nanoparticle Aggregates onto Substrates / Fiber

[0128]The coating of gold nanoparticle aggregates onto a substrate / fiber was performed in two ways. First, by spin coating or drop casting a dilute solution of the aggregates onto the substrate. This yields a relatively thick film, however, it is not as stable as is necessary for many applications. The second method utilizes a tethering molecule, in this case trimethoxy[3-(methylamino)propyl]silane (APS). The substrate was cleaned prior to the silanization step by sonication in 2% solution of HELLMANEX or other surfactant, followed by 18 mΩ water.

[0129]The gold nanoparticle aggregates were then submerged in a 5 mM aqueous solution of APS to deposit the tethering molecules. After 1-2 minutes the substrate was rinsed with water, dried under nitrogen, and 40 μl of the aggregate solution was placed on the surface. After several seconds exposed to the solution, it was blown dry with nitrogen. This provided a significantly thinner ...

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Abstract

The invention is drawn to novel gold nanoparticles that are used in a dual optical method for sensitive and selective detection of antigens. The gold nanoparticle aggregates are synthesized from gold hydrochloride and sulfur salts in an aqueous solution. The aggregates can be selectively sized using a spectral notch filter that results in an improved product with versatile uses. The gold nanoparticles can also be used in improved optical communications devices.

Description

[0001]The present application claims priority to U.S. Provisional Patent Application Ser. No. 60 / 667,151 entitled “Novel Gold Nanoparticle Aggregates and Their Applications”, filed Mar. 30, 2005, and U.S. Provisional Patent Application Ser. No. 60 / 711,808 entitled “Novel Gold Nanoparticle Aggregates and Their Applications”, filed Aug. 26, 2005, which are herein incorporated by reference in their entirety for all purposes.FIELD OF THE INVENTION[0002]The present invention relates to particles comprising a metallic core and sulfur species on their surface with useful properties. The invention further relates to methods of using the particles for detecting chemical and biological analytes, and in use in optical communications.BACKGROUND[0003]During the 1980s Raman Scattering in fibers was demonstrated by Lin, Stolen, and other co-workers of AT&T Bell Laboratories in Holmdel, N.J. using Raman lasers operating between 0.3 to 2.0 μm. In the early years of the Raman fiber before extensive w...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/68C12M1/34G01N33/551
CPCG01N33/54313G01N33/585G01N33/553G01N21/658G01N33/54346G01N33/587G01N33/6854
Inventor ZHANG, JINSCHWARTZBERG, ADAMNORMAN, THADDEUSOSHIRO, TAMMY Y.GRANT, CHRISTIAN D.SUTPHEN, REBECCASEBALLOS, LEOZHANG, YIGU, CLAIRE
Owner UNIV OF SOUTH FLORIDA
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