Pharmaceutical composition containing L-carnitine and coenzyme Q10 as well as its preparation method

A composition and medicine technology, applied in compound preparation and preparation thereof, pharmaceutical composition comprising L-carnitine and coenzyme Q10 and preparation field thereof, can solve the problem that it cannot be safely used for human injection, large toxic and side effects, and turbid solution and other problems, to achieve good application prospects, good stability, economical and practical effects

Inactive Publication Date: 2012-07-11
LIAONING THINKING DECKER MEDICAL TECH +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Levocarnitine and coenzyme Q currently on the market 10 There are single preparations for sale, but if the two preparations are mixed directly, the solution will be cloudy and cannot be used
Patent CN1475211 discloses a kind of levocarnitine and coenzyme Q 10 The compound preparation and its preparation method, the preparatio...

Method used

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  • Pharmaceutical composition containing L-carnitine and coenzyme Q10 as well as its preparation method
  • Pharmaceutical composition containing L-carnitine and coenzyme Q10 as well as its preparation method
  • Pharmaceutical composition containing L-carnitine and coenzyme Q10 as well as its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Selection of Solubilizers in Compound Levocarnitine and Coenzyme Q10

[0038] Formulations were prepared according to the ingredients contained in the unit dosage forms shown in Table 1.

[0039] Table 1 Prescription design

[0040]

[0041] Preparation process of samples 1 to 5: heat the solubilizer to 50-60°C, add coenzyme Q 10 Dissolve in a solubilizer, adjust the pH value to 5.0 with hydrochloric acid, add activated carbon, decarbonize after stirring, add water for injection to make up to 500ml, filter, fill, sterilize, and observe the properties of the liquid at 40°C.

[0042] Preparation process of samples 6 to 16: heat the solubilizer to 50-60°C, add coenzyme Q 10 Dissolve in solubilizer, add levocarnitine after dissolving in water, adjust the pH value to 5.0 with hydrochloric acid, add activated carbon, decarbonize after stirring, add water for injection to 500ml, filter, fill, sterilize, and Place it at 40°C to observe the properties of the liq...

Embodiment 2

[0049] Example 2 Levocarnitine and coenzyme Q 10 oral liquid

[0050] prescription:

[0051]

[0052]

[0053] Preparation:

[0054] Take the prescribed amount of polyoxyethylene castor oil EL35, heat to 30-40°C, add coenzyme Q 10 , stir to dissolve;

[0055] Take 70% of the prescribed amount of purified water, add the prescribed amount of aspartame and stir to dissolve it, add the prescribed amount of levocarnitine and stir to dissolve it;

[0056] Mix the above two medicinal solutions, add malic acid to adjust the pH to 4.0, add 0.5% activated carbon in the total volume, stir evenly, after 30 minutes, decarbonize, add purified water to the total volume, fine filter, fill, and sterilize, that is have to.

Embodiment 3

[0057] Example 3 Levocarnitine and Coenzyme Q 10 Injection

[0058]

[0059] Preparation:

[0060] Take the prescribed amount of polyethylene glycol 15 hydroxystearate, heat to 50-60°C, add coenzyme Q 10 , stir to dissolve;

[0061] In addition, take 70% of the prescribed amount of water for injection, add the prescribed amount of levocarnitine and stir to dissolve it;

[0062] Mix the above two medicinal solutions, add hydrochloric acid to adjust the pH to 4.5, add 0.5% activated carbon in the total volume, stir evenly, after 30 minutes, decarbonize, add water for injection to the total volume, fine filter, fill, seal, sterilize, Instantly.

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PUM

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Abstract

The present invention provides a pharmaceutical composition containing L-carnitine and coenzyme Q10 as well as its preparation method. The pharmaceutical composition comprises L-carnitine or its pharmaceutically acceptable salt or ester, coenzyme Q10 or its pharmaceutically acceptable salt or ester, and a solubilizing agent, wherein the solubilizing agent comprises one or more selected from polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, stearic acid polyoxyethylene ester and polyethylene glycol 15 hydroxy stearate . The prepared pharmaceutical composition which takes L-carnitine and coenzyme Q10 and/or their pharmaceutically acceptable salts as an active ingredient has the advantages of good stability, high security, stable preservation for long-term and safe usage; and the pharmaceutical composition can fully perform the synergy of two ingredients, has the merits of convenient usage, economical and practical effects, and possesses a good prospect.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and relates to a drug containing levocarnitine and coenzyme Q 10 Pharmaceutical composition and preparation method thereof. Specifically, the present invention relates to a kind of with levocarnitine and coenzyme Q 10 A compound preparation with active ingredients and a preparation method thereof. Background technique [0002] L-carnitine, also known as L-carnitine, is an amino acid derivative that exists in almost all human cells. L-carnitine is a natural substance in the body needed in mammalian energy metabolism, and its main function is to promote lipid metabolism. In mitochondria, L-carnitine transports long-chain fatty acids across the inner mitochondrial membrane, and in mitochondria, L-carnitine undergoes β-oxidation to produce adenosine triphosphate (ATP) to provide energy for organisms. In addition, other functions of levocarnitine are: oxidation of medium-long chain fatty acids; o...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K47/44A61K47/10A61K47/18A61K31/205A61P3/02A61K31/122A61K47/12A61K47/14
Inventor 王勇王淑君陈斌关玉晶刘莹刘婷
Owner LIAONING THINKING DECKER MEDICAL TECH
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