Medicament composition and application thereof

A composition and drug technology, which is applied in the direction of drug combination, antibacterial drugs, antitumor drugs, etc., can solve the problem of low cure rate and so on

Active Publication Date: 2012-07-04
CHANGZHOU HI TECH DISTRICT MULTIPLE DIMENSION IND TECH INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently there are many drugs for tr

Method used

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  • Medicament composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1 Protective Effect on Rat Gastric Mucosa Injury

[0046] 1. Experimental purpose: To observe the protective effect of rhein, levocarnitine and rhein + levocarnitine in different dosage ratios on gastric mucosal injury in rats.

[0047] 2. Experimental method:

[0048] 2.1 Model preparation and testing indicators

[0049] Male SD rats were randomly divided into groups according to body weight, and the corresponding doses were given by intragastric administration for 7 days respectively, and the volume of administration was 1ml / 100g body weight. One hour later, intragastric administration of 65% ethanol was administered (administration volume: 4ml / 1000g body weight); one hour after modeling, the animal was sacrificed, the abdominal cavity was opened, the cardia was ligated, and 10ml of 4% formaldehyde solution was injected into the stomach from the pylorus, and ligated quickly Pylorus, the whole stomach was taken out, fixed in the same concentration of formalde...

Embodiment 2

[0070] Example 2 Protective effect of diacetylrhein+acetyl-levocarnitine on gastric mucosal injury in rats

[0071] 1. Experimental purpose: To observe the protective effect of diacetylrhein + acetyl-levocarnitine in different dosage ratios on gastric mucosal injury in rats.

[0072] 2. Experimental method:

[0073] 2.1 Model preparation and testing indicators

[0074] Male SD rats were randomly divided into groups according to body weight, and the corresponding doses were given by intragastric administration for 7 days respectively, and the volume of administration was 1ml / 100g body weight. One hour later, intragastric administration of 65% ethanol was administered (administration volume: 4ml / 1000g body weight); one hour after modeling, the animal was sacrificed, the abdominal cavity was opened, the cardia was ligated, and 10ml of 4% formaldehyde solution was injected into the stomach from the pylorus, and ligated quickly Pylorus, the whole stomach was taken out, fixed in t...

Embodiment 3

[0082] Example 3 L-carnitine: a combination pharmaceutical preparation of different dosage ratios of rhein.

[0083] The combined drug containing levocarnitine and rhein of the present invention can prepare various combined drug preparations containing different levocarnitine and rhein dosage ratios according to the following data:

[0084] Levocarnitine 1mg-1000mg / kg / day; Rhein 0.2mg-50mg / kg / day

[0085] Determine the ratio range from 1000g:0.2g to 1g:50g

[0086] L-Carnitine: Rhein L-Carnitine (heavy): Rhein (heavy)

[0087] 1:0.0002 1000g:0.2g

[0088] 1:0.0004 1000g:0.4g

[0089] 1:0.0005 1000g:0.5g

[0090] 1:0.0008 1000g:0.8g

[0091] 1:0.001 1000g:1g

[0092] 1:0.003 1000g:3g

[0093] 1:0.005 1000g:5g

[0094] 1:0.007 1000g:7g

[0095] 1:0.01 1000g:10g

[0096] 1:0.03 1000g:30g

[0097] 1:0.05 1000g:50g

[0098] 1:0.07 1000g:70g

[0099] 1:0.1 1000g:100g

[0100] 1:0.3 1000g:300g

[0101] 1:0.5 1000g:500g

[0102] 1:0.7 1000g:700g

[0103] 1:1 1000g:100...

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Abstract

The invention relates to a medicament composition, a medicament preparation containing the medicament composition and application of the medicament composition. The medicament composition comprises levocarnitine or derivative thereof and rhein or pharmaceutically acceptable salt thereof. The medicament composition shows an excellent effect of preventing and treating mucosal injury caused by various reasons or diseases caused or characterized by the injury.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to a pharmaceutical composition and its pharmaceutical preparation and application. technical background [0002] Mucosal tissue is a membranous structure composed of epithelial tissue rich in secretory glands and small cell vascular network, located in the body cavity, such as the digestive tract (including oral cavity, gastrointestinal tract, esophagus, colon, etc.), nasal cavity, respiratory tract and reproductive system . The oral and gastrointestinal mucosa acts as an important protective barrier against the invasion of microorganisms and pathogens [0003] Mucosa tissues in the digestive tract (including oral cavity and gastrointestinal tract) are always exposed to very harsh environments, for example, corroded by irritants such as strong acids (such as hydrochloric acid), alcohol, and digestive enzymes. Mucous membrane damage in the digestive tract can cause discomfort to th...

Claims

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Application Information

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IPC IPC(8): A61K31/205A61K31/192A61K31/222A61K31/221A61P1/02A61P1/04A61P35/00A61P31/04
Inventor 杜娟顾书华
Owner CHANGZHOU HI TECH DISTRICT MULTIPLE DIMENSION IND TECH INST
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