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Levocarnitine coating tablet and preparation method thereof

A technology for coating tablets and film coating, which can be applied to pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as hygroscopicity, and achieve low production cost, high efficiency, Simple to use effects

Inactive Publication Date: 2012-09-12
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Levocarnitine is a crystalline powder with strong hygroscopicity; the dosage forms of levocarnitine medicines currently on the market are mainly injections and oral liquids, and there are also reports on the preparation of levocarnitine tablets, but there is no Solve the problem of its hygroscopicity well; the present invention adopts film coating technology to prepare levocarnitine coated tablets, which solves the problem of hygroscopicity in levocarnitine medicine

Method used

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  • Levocarnitine coating tablet and preparation method thereof
  • Levocarnitine coating tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] The present embodiment prepares 1000 levocarnitine coated tablets, the steps are as follows:

[0021] (1) Pass levocarnitine, starch, microcrystalline cellulose and magnesium stearate through 80-mesh sieve respectively, and set aside;

[0022] (2) Take standby levocarnitine 250g, starch 75g and microcrystalline cellulose 121.5g, mix and make mixed powder;

[0023] (3) Add the ethanol solution of povidone K30 of 15g8% mass percent concentration in the mixed powder of levocarnitine, starch and microcrystalline cellulose to make soft material and cross 16 mesh sieves and make granule, at 55-60 Dry at ℃ temperature;

[0024] (4) Add 3.5 g of magnesium stearate to the dried granules and cross a 16-mesh sieve and mix uniformly;

[0025] (5) compressing the uniformly mixed granules to make levocarnitine tablet core;

[0026] (6) Put the levocarnitine tablet cores into the coating pan to coat the pressed levocarnitine tablet cores, adjust the speed of the coating pan to 6 rp...

Embodiment 2

[0029] The present embodiment prepares 1000 levocarnitine coated tablets, the steps are as follows:

[0030] (1) Pass levocarnitine, starch, microcrystalline cellulose and magnesium stearate through 80-mesh sieve respectively, and set aside;

[0031] (2) Take standby levocarnitine 230g, starch 55g and microcrystalline cellulose 100g, mix and make mixed powder;

[0032] (3) Add the ethanol solution of povidone K30 of 10g8% mass percentage concentration in the mixed powder of levocarnitine, starch and microcrystalline cellulose to make soft material and cross 16 mesh sieves and make granule, at 55-60 Dry at ℃ temperature;

[0033] (4) Add 1.5 g of magnesium stearate to the dried granules and cross a 16-mesh sieve to mix evenly;

[0034] (5) compressing the uniformly mixed granules to make levocarnitine tablet core;

[0035] (6) Put the levocarnitine tablet cores into the coating pan to coat the pressed levocarnitine tablet cores, adjust the speed of the coating pan to 6 rpm, ...

Embodiment 3

[0038] The present embodiment prepares 1000 levocarnitine coated tablets, the steps are as follows:

[0039] (1) Pass levocarnitine, starch, microcrystalline cellulose and magnesium stearate through 80-mesh sieve respectively, and set aside;

[0040] (2) Take standby levocarnitine 270g, starch 95g and microcrystalline cellulose 140g, mix and make mixed powder;

[0041] (3) Add the ethanol solution of povidone K30 of 20g8% mass percentage concentration in the mixed powder of levocarnitine, starch and microcrystalline cellulose to make soft material and cross 16 mesh sieves and make granule, at 55-60 Dry at ℃ temperature;

[0042] (4) Add 5.5 g of magnesium stearate to the dried granules and cross a 16-mesh sieve to mix evenly;

[0043] (5) compressing the uniformly mixed granules to make levocarnitine tablet core;

[0044] (6) Put the levocarnitine tablet cores into the coating pan to coat the pressed levocarnitine tablet cores, adjust the speed of the coating pan to 6 rpm, ...

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Abstract

The invention discloses a levocarnitine coating tablet and a preparation method thereof, and belongs to the technical field of the preparation of medicines. The levocarnitine coating tablet comprises levocarnitine, starch, microcrystalline cellulose, 8 mass percent ethanol solution of povidone K30, magnesium stearate, an ethanol solution of an Opadry 21K film coating premix and an aqueous solution of Opadry 85 G film coating premix. The preparation method comprises the following steps of: sieving the levocarnitine, the starch, the microcrystalline cellulose and the magnesium stearate with an 80-mesh sieve for later use; mixing the levocarnitine, the starch and the microcrystalline cellulose uniformly to prepare mixed powder, adding the ethanol solution of the povidone K30 into the mixed powder to prepare soft materials, and sieving with a 16-mesh sieve to prepare granules and drying; adding the dried granules into the magnesium stearate, sieving with a 16-mesh sieve, and mixing uniformly; and tabletting, and spraying a film coat on the surface of the tablet. The levocarnitine coating tablet can be stored easily for a long term and does not absorb moisture, and is low in production cost; and the preparation method is easy to operate and high in efficiency.

Description

Technical field: [0001] The invention belongs to the technical field of medicine preparation, and relates to a coated tablet and a preparation method thereof, in particular to a levocarnitine coated tablet and a preparation method thereof. Background technique: [0002] The chemical name of L-Carnitine is L-βhydroxy-γ-trimethylaminobutyric acid, also known as L-carnitine. It is an essential substance in the energy metabolism of mammals. Its main function is to promote lipid metabolism in organisms. Metabolism of substances; long-chain fatty acids cannot directly pass through the inner mitochondrial membrane, and the metabolic process requires the participation of L-carnitine. L-carnitine introduces long-chain fatty acids into mitochondria and makes fatty acyl-CoA under the action of mitochondrial enzymes Carry out β-oxidation, and at the same time transport the acetyl group of the product of β-oxidation out of the mitochondria, reduce the combination of acetyl group and free...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K31/205A61K47/38A61P3/00
Inventor 曹玉黄菊红李萍王晨静朱莉曲海军李昂王春波
Owner QINGDAO UNIV
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