Drug combination containing levocarnitine derivatives and preparation method of drug combination

A technology of composition and derivatives, which is applied in the field of divisional application, can solve the problems of expensive processing costs, etc., and achieve the effect of long validity period, not easy to oxidize, and high purity

Inactive Publication Date: 2012-07-18
南京海辰药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the easy degradation of acetyl L-carnitine chloride, these powders need to be prepared and processed at low temperature, requiring special equipment and operations, so the processing cost is relatively expensive

Method used

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  • Drug combination containing levocarnitine derivatives and preparation method of drug combination
  • Drug combination containing levocarnitine derivatives and preparation method of drug combination
  • Drug combination containing levocarnitine derivatives and preparation method of drug combination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: 0.5g / bottle specification, 1000 freeze-dried powder injection formulations:

[0019] Acetyl L-carnitine Chloride (Type II and / or Type III) 590g

[0020] Mannitol 1000g

[0021] Add water for injection to 8000mL, make 1000 tubes in total

[0022] Wherein, acetyl-levocarnitine chloride is the main drug, and the specification in this embodiment is that each bottle contains acetyl-levocarnitine (C 9 h 17 NO 4 )0.5g. Mannitol is used as the skeleton supporting part of the chlorinated acetyl-levocarnitine pharmaceutical composition. Water for injection is used as a solvent for dissolving raw materials, and an appropriate amount is added according to the concentration of the liquid medicine and the loading capacity of each medicine. The preparation process of the preparation is as follows:

[0023] a. According to the ingredients of the formulation in Example 1, take 590 g of acetyl levocarnitine chloride and 1000 g of mannitol, add an appropriate amount of...

Embodiment 2

[0026] Embodiment 2: 0.5g / bottle specification, 1000 freeze-dried powder injection formulations:

[0027] Acetyl L-carnitine Chloride (Type II and / or Type III) 590g

[0028] Lactose 800g

[0029] Add water for injection to 8000mL, make 1000 tubes in total

[0030] Wherein, acetyl-levocarnitine chloride is the main drug, and the specification in this embodiment is that each bottle contains acetyl-levocarnitine (C 9 h 17 NO 4 )0.5g. Lactose is used as the skeleton supporting part of the acetyl-levocarnitine chloride pharmaceutical composition. Water for injection is used as a solvent for dissolving raw materials, and an appropriate amount is added according to the concentration of the liquid medicine and the loading capacity of each medicine. The preparation process of the preparation is as follows:

[0031] a. According to the formulation ingredients of Example 2, take 590 g of acetyl levocarnitine chloride and 800 g of lactose, add an appropriate amount of water for inje...

Embodiment 3

[0034] Embodiment 3: 0.5g / bottle specification, 1000 freeze-dried powder injection formulations:

[0035] Acetyl L-carnitine Chloride (Type II and / or Type III) 590g

[0036] Sorbitol 1000g

[0037] Add water for injection to 8000mL, make 1000 tubes in total

[0038] Wherein, acetyl-levocarnitine chloride is the main drug, and the specification in this embodiment is that each bottle contains acetyl-levocarnitine (C9 h 17 NO 4 )0.5g. Sorbitol is used as the skeleton supporting part of the acetyl levocarnitine chloride pharmaceutical composition. Water for injection is used as a solvent for dissolving raw materials, and an appropriate amount is added according to the concentration of the liquid medicine and the loading capacity of each medicine. The preparation process of the preparation is as follows:

[0039] a. According to the formulation ingredients of Example 3, take 590 g of acetyl levocarnitine chloride and 1000 g of sorbitol, add an appropriate amount of water for i...

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Abstract

The invention relates to a drug combination containing levocarnitine derivatives and a preparation method of the drug combination, wherein, the drug combination is stable under both a solid state and a liquid state. The drug combination comprises ethanoyl chloride levocarnitine with crystal form II and / or crystal form III, proper lyophilized injectable powder excipients and alkali or buffer agents.

Description

technical field [0001] The present invention is a divisional application of the prior application number 201110457777.7. The present invention relates to pharmaceutical compositions containing levocarnitine derivatives and processes for the preparation of such compositions. The pharmaceutical composition of the present invention comprises type II and / or type III acetyl levocarnitine chloride, a medically acceptable excipient for freeze-dried powder injection and alkali or buffer. Background technique [0002] L-carnitine (LC) is an essential natural substance in mammalian energy metabolism, and its main function is to promote lipid metabolism. It can not only bring long-chain fatty acids into the mitochondrial matrix, promote their oxidation and decomposition, provide energy for cells, but also export short-chain fatty acyl groups produced in mitochondria. [0003] Acetyl-L-carnitine (Acetyl-L-carnitine), namely acetyl-L-carnitine, is the acetylated form of L-carnitine, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/205A61P25/28A61P3/02
Inventor 汪宗华林家红刘志芳郁博媛曹于平
Owner 南京海辰药业股份有限公司
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