Method for synthesizing levocarnitine by taking D-(-)-tartaric acid as raw material

A technology of tartaric acid and dibenzyl tartrate, applied in chemical instruments and methods, preparation of organic compounds, chemical recovery, etc., to achieve the effects of low cost, mild reaction conditions, and simple process technology

Active Publication Date: 2013-04-17
开原亨泰营养科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The research result of this project is a technical innovation of deepening and greening the production and processing of L-carnitine, obtaining high value-added products and improving economic benefits. The development o...

Method used

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  • Method for synthesizing levocarnitine by taking D-(-)-tartaric acid as raw material
  • Method for synthesizing levocarnitine by taking D-(-)-tartaric acid as raw material
  • Method for synthesizing levocarnitine by taking D-(-)-tartaric acid as raw material

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Embodiment

[0050] Synthesis of D-(-)-dibenzyl tartrate:

[0051] Add 45g of D-(-)-tartaric acid, 2.25g of boric acid, 90ml of benzyl alcohol and 120ml of toluene solution into a 500ml three-necked flask. Toluene is the water-carrying agent. Stir and heat up until all the solids are dissolved, then heat up to reflux, and reflux at 116°C Divide the water, react until the water volume in the water separator no longer increases, record the water division. After cooling to room temperature, pour the reaction solution into a separatory funnel, add an equal volume of saturated NaHCO3 solution to wash until no bubbles are formed, and then wash the oil layer with distilled water for 2 to 3 times, let it stand for layers, and use anhydrous magnesium sulfate to treat the ester layer. Carry out drying, leave standstill overnight, filter, and filtrate is poured into distillation bottle and carries out normal pressure distillation, removes toluene, then decompression distillation removes benzyl alcoho...

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Abstract

The invention discloses a method for synthesizing levocarnitine by taking D-(-)-tartaric acid as raw material, and relates to a method for synthesizing levocarnitine. The method takes D-(-)-tartaric acid as raw material and comprises the following steps of: (I) synthesizing D-(-)-dibenzyl tartrate with benzyl alcohol by taking boric acid as a catalyst; (2) reducing the D-(-)-dibenzyl tartrate to obtain D-(-)-2,3,4-methyl trihydroxy benzene by taking sodium borohydride as a catalyst; (III) bromizing in a hydrogen bromide acetate solution to obtain D-(-)-3-hydroxy-2,4-methyl dibromo-benzene; (IV) introducing hydrogen and performing selective debromination hydrogenation to obtain D-(-)-3-hydroxyl-4-methyl bromobenzene by using a Pd/C catalyst; and (V) performing trimethylamine amination, hydrolysis and ion exchange to obtain levocarnitine. The process flow does not adopt a resolving agent and cyanide, the reaction conditions are mild, pollution is prevented, and the cost is low.

Description

technical field [0001] The invention relates to a method for synthesizing levocarnitine, in particular to a method for synthesizing levocarnitine by using D-(-)-tartaric acid as a raw material. Background technique [0002] L-carnitine is named "vitamin BT". It is the only carrier for fatty acids to be transported into the mitochondria of cells. Therefore, the most important function of L-carnitine is to promote the β-oxidation of fatty acids, reduce the content of serum cholesterol and triglycerides, and improve the body's tolerance. In addition, L-carnitine also has physiological functions such as: detoxifying acyl residues, participating in the metabolism of branched-chain amino acids, regulating glycogen production, and promoting ATP transport. In 2010, the "Food Safety Law of the People's Republic of China" approved the expansion of the scope and amount of use of L-carnitine. [0003] At present, only a few countries such as the United States, Italy, Japan and China c...

Claims

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Application Information

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IPC IPC(8): C07C229/22C07C227/18
CPCY02P20/584
Inventor 王国胜申杰谭春红王志东宁志高
Owner 开原亨泰营养科技有限公司
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