Medicine combination capable of reducing myocardial infarction area and use thereof
一种心肌梗死、组合物的技术,应用在含其的药物制剂领域,能够解决血压波动、缩小心肌梗死没有达到、不能耐受等问题
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Embodiment 1
[0043] Example 1 To observe the protective effects of trimetazidine, levocarnitine and trimetazidine+levocarnitine in different dosage ratios on acute myocardial infarction in rats.
[0044] Trimetazidine and levocarnitine were used to calculate the equivalent doses for rats based on the human doses recommended by the manufacturer. Four dose groups were set up for each drug, and there were 5 groups in total as solvent-added controls. They are:
[0045] Trimetazidine: solvent control group, trimetazidine drugs 1, 3, 6, 9 mg / kg.
[0046] Levocarnitine: solvent control group, levocarnitine 100, 300, 600, 900mg / kg.
[0047] The dosage of trimetazidine+levocarnitine, according to the efficacy of trimetazidine and levocarnitine, after removing the highest dose of the two groups, the dosage of trimetazidine+levocarnitine ( mg / kg) was set to 3+100, 3+300, 3+600, 1+300, 6+300, plus solvent control, a total of 6 groups.
[0048] Male SD rats with a body weight of 200±20 grams were se...
Embodiment 2
[0061] Example 2 To observe the protective effect of trimetazidine + levocarnitine in different dosage ratios on acute myocardial infarction in rats.
[0062] The dosage of trimetazidine+levocarnitine, according to the efficacy of trimetazidine and levocarnitine, after removing the highest dose of the two groups, the dosage of trimetazidine+levocarnitine ( mg / kg) are set as in Table 4.
[0063] Male SD rats with a body weight of 200±20 grams were selected. Animals were weighed, and a single dose was administered intraperitoneally, with a dose volume of 5 ml / kg. Immediately anesthetized with ether, fixed on the mouse table in supine position, disinfected the skin of the left chest with 75% alcohol, opened the chest along the 3rd-4th intercostal space along the left sternal border, cut the pericardium, exposed the heart, and found it between the conus pulmonary artery and the left atrial appendage. Out of the anterior descending coronary artery, use a round non-invasive suture...
Embodiment 3
[0066] Example 3 Combination pharmaceutical preparations of levocarnitine: trimetazidine in different dosage ratios.
[0067] The combined drug containing levocarnitine and trimetazidine of the present invention can prepare various combined drug preparations containing different levocarnitine and trimetazidine dosage ratios according to the following data:
[0068] Levocarnitine 10mg-600mg / kg / day; trimetazidine 0.01mg-3mg / kg / day
[0069] Determine the ratio range from 30g:1mg to 0.5g:200mg
[0070] Levocarnitine: Trimetazidine Levocarnitine (heavy): Trimetazidine (heavy)
[0071] 1:0.000016 1000g:16mg
[0072] 1:0.00004 1000g:40mg
[0073] 1:0.00005 1000g:50mg
[0074] 1:0.0001 1000g:100mg
[0075] 1:0.0005 1000g:500mg
[0076] 1:0.001 1000g:1g
[0077] 1:0.002 1000g:2g
[0078] 1:0.003 1000g:3g
[0079] 1:0.004 1000g:4g
[0080] 1:0.005 1000g:5g
[0081] 1:0.006 1000g:6g
[0082] 1:0.007 1000g:7g
[0083] 1:0.008 1000g:8g
[0084] 1:0.009 1000g:9g
[0085] 1:0....
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