Preparation and application of external parasite expelling and itching relieving composition of traditional Chinese medicine abrus cantoniensis hance

Abstract

The invention provides preparation and application of an external parasite expelling and itching relieving composition of traditional Chinese medicine abrus cantoniensis hance. The external parasite-expelling and itching-relieving composition of the traditional Chinese medicine abrus cantoniensis hance is prepared by taking an abrus cantoniensis hance or abrus mollis hance water extract or ethanol extract as a main raw material, combining menthol and borneol under the guidance of a traditional Chinese medicine theory, and supplementing necessary ointment and cream auxiliary materials. The composition has the effects of expelling insects and relieving itching, can be used for preventing mosquito and insect bites so that the mosquitoes and the insects do not like close to the body, and can be used for relieving itching after mosquito and insect bites; the anti-inflammatory and antibacterial effects and the like are realized, and the itching caused by skin inflammation reaction after mosquito and insect bites can be treated. The composition provided by the invention can be used for preparing external ointment and cream, and can also be used for preparing linimentum, liniment, lotion, spray and the like.

Description

Technical Field

[0001] The present invention relates to the fields of medical technology and daily chemical industry, and in particular to the preparation of an external anthelmintic and antipruritic composition of a traditional Chinese medicine, Glechoma longituba, and its applications in anthelmintic, antipruritic and anti-inflammatory aspects. Background Art

[0002] The Chinese medicinal herb, Abruscantoniensis hance, is a specialty herb native to the Lingnan region of my country. It is the dried whole herb of the leguminous plant, Abruscantoniensis hance. The whole herb has the properties of dispelling dampness and relieving jaundice, clearing away heat and detoxifying, and soothing the liver and relieving pain. It is used to treat damp-heat jaundice, flank discomfort, epigastric distension and pain, and mastitis. The "Nanning City Pharmacopoeia" states that it "treats infectious hepatitis and sprained bones." The "Lingnan Herbal Medicine" states that it "soothes the liver, harmonizes the spleen, and heals fractures." The "National Compendium of Chinese Herbal Medicines" states that it "treats acute and chronic hepatitis, ascites caused by cirrhosis, stomachache, rheumatic bone pain, and insect and snake bites, and can be used as a refreshing summer beverage." Modern research on Abruscantoniensis hance has demonstrated antioxidant, anti-cellular proliferation, anti-cancer, and immunomodulatory effects. The main components extracted from Abruscantoniensis hance include soybean saponin Bb, abrin saponin, schaftoside, abrinine, and erythrine.

[0003] Literature reports that total flavonoids from kudzu vine effectively alleviate LPS-induced inflammatory responses in mouse peritoneal macrophages in vitro. In animal anti-inflammatory experiments, total flavonoids from kudzu vine significantly inhibited xylene-induced mouse ear swelling and cotton ball granulomas, with inhibitory effects approaching those of the positive control drug dexamethasone. Soy saponins, the main component of kudzu vine, inhibited LPS-induced release of the inflammatory marker prostaglandin E2 (PGE2), similar to the NF-κB inhibitor BAY117082. They also inhibited cyclooxygenase-2 (COX-2) expression in a dose-dependent manner by inhibiting NF-κB activation. Soy saponins inhibited LPS-induced PI3K / Akt activation and reactive oxygen species (ROS) production, increased superoxide dismutase (SOD) activity and the GSH / GSSG ratio, and reduced inflammation. The main chemical component, soybean saponin Bb, can inhibit the recruitment of TLR4 to lipid rafts and its interaction with receptor molecules by inhibiting the production of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent ROS, inhibiting the production of pro-inflammatory molecules and the activation of NF-κB, thereby blocking the inflammatory response in the early stage.

[0004] When mosquitoes, fleas, mites, midges, bedbugs, and other insects bite the skin, they release toxins and proteins, triggering an immune response within the skin's blood vessels, leading to localized acute allergic and inflammatory reactions. This condition is known as insect bite dermatitis. Bites on exposed skin often cause rashes, papules, and blisters, centered around the bite mark, often accompanied by itching, burning, and stinging. In severe cases, toxins can enter the bloodstream, triggering bacteremia and systemic inflammation, or even the spread of diseases such as dengue fever and malaria. Summer is a season of mosquito infestation, with mosquitoes active in most areas of the country, making mosquito bites extremely common. This is particularly true in southern China, where the humid climate and abundant vegetation allow mosquitoes to thrive in this hot and humid environment, making insect bite dermatitis highly susceptible. Traditional Chinese Medicine (TCM) considers insect bite dermatitis to be caused by the accumulation of exogenous toxins. Based on the presenting symptoms, it is diagnosed as a stagnation of toxins in the skin meridians, qi stagnation, and blood stasis. Treatment should focus on clearing heat and detoxifying, promoting blood circulation and reducing swelling, dispelling wind and relieving pain, and alleviating itching. Herba Cervi Paniculatae is a traditional Chinese medicine commonly used in southern China. It has the effects of clearing away heat and detoxifying, and there are records of its use in treating insect and snake bites. Menthol is the most important extract of the Chinese medicine mint. It has the effects of clearing away heat and detoxifying, dispelling wind and relieving itching. It can be used externally to treat skin itching, non-transparent rashes, and dry and wet scabies. Borneol is pungent and bitter in taste and cool in nature. It can open the mind and relieve swelling and relieve pain. This antipruritic composition uses Herba Cervi Paniculatae as the main drug, which clears away heat and detoxifies, dispels wind and relieves itching. Mint is the auxiliary drug, which dispels wind and relieves itching, and has a refreshing and cooling effect. It assists the main drug in exerting its antipruritic effect. At the same time, the unique cooling feeling and fragrance of menthol reduce the discomfort caused by itching after the composition is applied, and can make mosquitoes dislike getting close. The combination of the three Chinese medicines clears away heat and detoxifies, relieves swelling and relieves itching, and drives away insects, which is in line with the theory of traditional Chinese medicine. Herba Cervi Paniculaee, mint, etc. are traditional Chinese medicines with medicinal and edible properties, are highly safe, have few side effects, and have good application prospects. Summary of the Invention

[0005] The purpose of the present invention is to provide a composition of the Chinese medicinal herbs of Aconitum carmichaelii and Aconitum pubescens for expelling insects and relieving itching and a preparation method thereof, and the application of the composition includes external cream pharmaceutical preparations or daily protective cosmetics.

[0006] The Chinese medicinal herbs, such as chordata and chordata, are derived from Abrus cantoniensis Hance and Abrus mollis Hance, respectively, plants of the genus Abrus in the Leguminosae family. The extracts used in the composition are extracted from an ethanol solution, pure water, or drinking water. Menthol is an extract of Mentha canadensis L., a mint plant of the Lamiaceae family. Borneol is extracted from fresh branches and leaves of Camphora officinarum Nees, a plant of the Lauraceae family, or is a synthetic borneol obtained through chemical synthesis.

[0007] The invention discloses a wormwood herb antler relieving and itching composition comprising 1-3 parts of wormwood herb extract, 4-10 parts of menthol, 2-6 parts of borneol, 2-6 parts of 3% glycerol solution and 250-500 parts of external preparation matrix.

[0008] The invention discloses a herba scutellariae anthelmintic and antipruritic composition comprising 1-3 parts of herba scutellariae anthelmintic extract, 4-10 parts of menthol, 2-6 parts of borneol, 2-6 parts of 3% glycerol solution and 250-500 parts of external preparation matrix.

[0009] The invention discloses a preparation method of an alcohol extract of chordate herb or hairy chordate herb. The method comprises the following steps: taking 1 part of chordate herb or hairy chordate herb, adding 8 times the amount of 70% ethanol solution, performing reflux extraction for 2 hours, filtering, adding 6 times the amount of 70% ethanol solution to the filter residue, performing reflux extraction for 2 hours, filtering, discarding the filter residue, combining the two filtrates, recovering the solution, drying, and grinding into powder.

[0010] The invention discloses a preparation method of an extract of chordata or chordata. The method comprises the following steps: taking 1 part of chordata or chordata, adding 10 times the amount of drinking water solution, heating and boiling for 2 hours, filtering, adding 8 times the amount of drinking water to the filter residue, boiling for 2 hours, filtering, discarding the filter residue, combining the two filtrates, recovering the solution, drying, and grinding into powder.

[0011] The invention discloses an external preparation matrix composition comprising butyl methoxydibenzoylmethane, methoxycinnamic acid hexyl acetate, vitamin E, dimethyl silicone oil, ethylparaben, phenyl salicylate, disodium EDTA, stearic acid, glyceryl monostearate, Tween-80, nano titanium oxide, etc.; or 1000-1500 parts of PEG-7 stearate, 200-300 parts of oleic acid macrogol glyceride (EP), 200-300 parts of liquid paraffin, 10-20 parts of sodium benzoate, and 5000-9000 parts of distilled water.

[0012] The invention discloses the application scope of the composition. The composition has the effects of repelling insects and relieving itching, can be used to prevent mosquito and insect bites, make mosquitoes and insects dislike approaching, and can be used to relieve itching after mosquito and insect bites.

[0013] The invention discloses the anti-inflammatory efficacy and application of the composition: the composition has anti-inflammatory and antibacterial effects and can be used for relieving itching caused by skin inflammatory reactions after mosquito and insect bites.

[0014] The present invention discloses the application form of the composition: the composition can be used to prepare external ointments and creams, and is not limited to the above preparations, but can also be used to prepare liniments, film coatings, lotions, etc.

[0015] The optimized solution of the present invention is as follows: 4-10 parts of menthol and 2-6 parts of borneol are added to a mortar in equal amounts in increments and ground together. After the two medicines are dissolved together, 2-6 parts of a 3% glycerol solution are added to dissolve them, and then 1-3 parts of chicken bone grass extract powder are added and stirred to mix well to prepare a mixture of the main ingredients of the preparation. Distilled water is heated to 60-90°C, sodium benzoate is added, and stirred to dissolve as the aqueous phase. After mixing the prescribed amount of PEG-7 stearate, oleic acid macrogol glyceride (EP), and liquid paraffin, it is heated to 60-80°C, and the aqueous phase is added while stirring at a speed of 500rpm, and homogenized for 10 minutes. When the stirring is cooled to 40-50°C, the main ingredient mixture is added, stirred evenly, left to cool to room temperature, and filled and sealed.

[0016] An optimized embodiment of the present invention may also include: a topical matrix prepared from butyl methoxydibenzoylmethane, methoxycinnamic acid hexyl acetate, vitamin E, dimethicone, ethylparaben, phenyl salicylate, disodium EDTA, stearic acid, glyceryl monostearate, Tween-80, and nano-titanium oxide; 4-10 parts menthol and 2-6 parts borneol are added to a mortar in equal and increasing amounts, and the mixture is ground together. After the two drugs are dissolved, 2-6 parts 3% glycerol solution is added to dissolve them, and 1-3 parts of chordate extract powder are added and stirred to form a main ingredient mixture of the preparation. The main ingredient mixture is added to the topical matrix in equal and increasing amounts, mixed, filled, and sealed. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 : Picture of redness and swelling on children's ears after mosquito bites

[0018] Figure 2 : Effect picture after applying chicken bone grass anti-itch ointment DETAILED DESCRIPTION

[0019] The following examples illustrate specific implementation methods, further illustrating and supplementing the present invention. However, the scope of the present invention is not limited to the following examples. All technologies and applications based on the above-mentioned content of the present invention fall within the scope of the present invention.

[0020] Example 1

[0021] Aconitum cream for deworming and relieving itching

[0022] Step 1: Take 4 parts of menthol and 3 parts of borneol in a container and mix them together. Add 5 parts of 3% glycerol solution and mix well. Then take 3 parts of scutellaria baicalensis or scutellaria baicalensis extract and add them to the mixed solution and mix well.

[0023] Step 2: Mix 60-80 parts of PEG-7 stearate (T-63), 100-120 parts of polyethylene glycol glyceride (EP), and 100-120 parts of liquid paraffin, heat and dissolve, and stir evenly;

[0024] Step 3: Take 1 part of sodium benzoate and add 350-400 parts of distilled water to dissolve it;

[0025] Step 4: Add the aqueous solution from step 3 to the mixture from step 2 while stirring homogeneously, and stir to mix thoroughly;

[0026] Step 5: Allow the mixed matrix from Step 4 to cool slightly. Add the mixture from Step 1 in portions and stir until homogenous. After cooling, fill and seal. Other requirements must comply with the relevant provisions for creams in the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0027] Example 2

[0028] Chicken bone grass spray for insect repellent and itching relief

[0029] Combine 4 parts menthol and 3 parts borneol in a container and blend. Add 5 parts 3% glycerol solution and mix thoroughly. Add 3 parts of the alcohol extract of Herba Cercidiphyllum or Herba Cercidiphyllum to the blended solution and blend thoroughly. Add 500-700 parts of ethanol and mix thoroughly. Then, add 200-400 parts of propylene glycol and mix thoroughly. Finally, add ethanol to 1000 mL and mix thoroughly. This product is ready. Other requirements must comply with the relevant provisions for sprays in the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0030] Example 3

[0031] Effect of using chicken bone grass cream to expel insects and relieve itching

[0032] Take the anti-insect and anti-itching chicken bone grass cream and apply it to the swollen ears of children after mosquito bites to relieve itching and swelling. Figure 1 ), apply an appropriate amount of anti-parasitic and anti-itching chicken bone grass cream for 12 hours, the swelling disappears and the itching stops ( Figure 2 ). This shows that the antiparasitic and antipruritic chicken bone grass cream has a clear effect of relieving itching and swelling.

Claims

1. A topical antiparasitic and antipruritic composition of Chinese herbal medicine, comprising: The preparation method is made from water extract or ethanol extract of Herba Corydalis or Herba Corydalis as main raw materials, combined with menthol and borneol under the guidance of traditional Chinese medicine theory, and supplemented with necessary ointment and cream auxiliary materials.

2. Aconitum carmichaelii and Aconitum pubescens are the dried whole herbs of the legume plants Guangzhou Abrus precatorius and Abrus precatorius pubescens. They have the effects of clearing heat and detoxifying, promoting dampness and relieving jaundice. They are often used to treat acute and chronic hepatitis, carbuncles, ulcers, etc., and have multiple pharmacological activities such as anti-inflammatory, antibacterial, antiviral, and antioxidant.

3. The water extract and ethanol solution extract of Aconitum carmichaelii and Aconitum truncatum have good anti-inflammatory, antibacterial and antioxidant effects.

4. The external use composition according to claim 1, wherein: In parts by weight, the composition comprises 1-3 parts of chordate cordata extract, 4-10 parts of menthol, 2-6 parts of borneol, 2-6 parts of 3% glycerol solution, and 250-500 parts of external preparation matrix.

5. The composition for external use according to claim 1, wherein: Calculated by weight, the composition comprises 1-3 parts of Herba Lycopodii extract, 4-10 parts of menthol, 2-6 parts of borneol, 2-6 parts of 3% glycerol solution and 250-500 parts of external preparation matrix.

6. According to claim 4, the external preparation matrix composition comprises butyl methoxydibenzoylmethane, methoxycinnamic acid hexyl acetate, vitamin E, dimethicone, ethylparaben, phenyl salicylate, disodium EDTA, stearic acid, glyceryl monostearate, Tween-80, nano titanium dioxide, etc.; or 1000-1500 parts of PEG-7 stearate, 200-300 parts of oleic acid macrogol glyceride (EP), 200-300 parts of liquid paraffin, 10-20 parts of sodium benzoate, and 5000-9000 parts of distilled water.

7. According to claim 1, the composition has the effects of repelling insects and relieving itching, can be used to prevent mosquito and insect bites, make mosquitoes and insects dislike getting close to the body, and can be used to relieve itching after mosquito and insect bites.

8. According to claim 3, the composition has anti-inflammatory and antibacterial effects and can be used to treat itching caused by skin inflammation after mosquito and insect bites.

9. According to claims 4-6, the composition can be used to prepare ointments and creams for external use, and is not limited to the above preparations, and can also be used to prepare liniments, film coatings, lotions, sprays, etc.

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