Externally applied medicine for treating herpes and use method thereof

Abstract

The invention discloses an external medicine for treating herpes and a use method, the external medicine is composed of a disinfectant and an external ointment, the disinfectant comprises scorpions, centipedes, snakes, scutellaria baicalensis, realgar, isatis roots and white spirit, the raw materials are soaked and extracted by adopting high-concentration white spirit, and the external medicine has the effects of clearing away heat and toxic materials, sterilizing and diminishing inflammation; the external ointment comprises the following raw materials: white vaseline, cowherb seed, frankincense, borneol, camphor and lithospermum erythrorhizon, and in the preparation process, medicinal powder and a matrix are fully fused to form a pasty preparation which is externally applied to an affected part. When in use, the disinfectant is applied to a herpes focus, then the Hegu acupoint and Ashi acupoint acupuncture operation is performed, and then the external ointment is applied to promote itching relieving, dryness, scabbing and tissue repair. The combination scheme has the advantages of quick effect, short treatment course and low recurrence rate, is suitable for external treatment of herpes simplex, herpes zoster and other various types of herpes, and has good safety and application and popularization values.

Description

Technical Field

[0001] The present invention relates to the technical field of external-use medicine preparations for skin diseases, in particular to an external-use medicine for treating herpes and a use method thereof. Background Art

[0002] Herpes is a common viral skin disease caused by the herpesvirus (Herpesviridae). Clinically, it manifests as localized blisters, erythema, and symptoms such as itching and burning on the skin or mucous membranes. Common types include herpes simplex (HSV-1 or HSV-2) and herpes zoster (caused by the varicella-zoster virus VZV). These viruses exhibit latent and recurrent characteristics, easily reactivating and recurring in response to decreased immunity, fatigue, infection, or excessive mental stress. Herpes zoster is particularly often associated with severe neuropathic pain, and some patients experience long-term neuropathic pain even after the lesions have healed, severely impacting their quality of life. Current Western medical treatments for herpes primarily rely on antiviral drugs such as acyclovir and valacyclovir, as well as symptomatic analgesics. However, these drugs carry certain side effects, such as gastrointestinal discomfort and liver and kidney burden. Furthermore, their efficacy is significantly affected by individual immune system differences, and relapses are common, requiring a long treatment cycle. Traditional Chinese medicine believes that herpes belongs to the category of "heat toxins" and "sores", and is mostly caused by internal liver fire and damp-heat toxins invading the skin. Its treatment is based on the principles of clearing heat and detoxifying, soothing the liver and dispersing nodules, and promoting blood circulation and unblocking meridians.

[0003] Traditional Chinese medicine topical treatments for herpes have a long history, offering advantages such as rapid local action, minimal side effects, and ease of use. They have become an important supplement to the combined use of traditional Chinese and Western medicine for the treatment of herpes. However, currently available topical Chinese patent medicines are mostly single ointments, which struggle to balance the dual needs of detoxification and sterilization with tissue repair. Furthermore, their simple usage, lack of scientific compatibility, and lack of control over the therapeutic rhythm make it difficult to achieve the therapeutic goals of rapid pain relief, shortening the course of the disease, and reducing recurrences.

[0004] Therefore, there is an urgent need to develop an innovative Chinese medicine external-use combination preparation with a scientific formula, a reasonable preparation structure, and a synergistic treatment mechanism, so as to achieve dual intervention on herpes symptoms and causes while ensuring safety of use.

[0005] For this reason, we are in urgent need of developing a kind of external-use medicine for treating herpes and using method to solve the above problems. Summary of the Invention

[0006] The object of the present invention is to provide an external-use medicine for treating herpes and a method of use thereof, so as to solve the problems raised by the above-mentioned background technology.

[0007] To achieve the above object, the present invention provides the following technical solution: an external-use medicine for treating herpes, comprising a disinfectant and an external-use ointment, wherein:

[0008] The disinfectant comprises, by weight, 20-50 parts of scorpions, 20-50 parts of centipedes, 20-50 parts of snakes, 20-50 parts of scutellaria baicalensis, 20-50 parts of realgar, 20-50 parts of isatis root, and 300-500 parts of liquor;

[0009] The external-use ointment comprises, by weight, 100-200 parts of white vaseline, 40-60 parts of fenugreek, 20-40 parts of frankincense, 20-50 parts of borneol, 15-25 parts of camphor and 20-40 parts of lithospermum officinale.

[0010] As a preferred technical solution of the present invention, the preferred ratio of the disinfectant is: 30-40 parts of scorpions, 30-40 parts of centipedes, 30-40 parts of snakes, 30-40 parts of scutellaria baicalensis, 30-40 parts of realgar, 30-40 parts of isatis root, and 400-450 parts of white wine.

[0011] As a preferred technical solution of the present invention, the preferred ratio of the external ointment is: 150-180 parts of white vaseline, 50-55 parts of fenugreek, 30-35 parts of frankincense, 30-40 parts of borneol, 20-22 parts of camphor, and 30-35 parts of lithospermum.

[0012] As a preferred technical solution of the present invention, the alcohol content of the liquor in the disinfectant is 65° or above, and the animal medicinal materials are mixed with the traditional Chinese medicine components and soaked in a sealed container for 25 to 30 days before the filtrate is taken for use.

[0013] As a preferred technical solution of the present invention, in the external ointment, fenugreek, frankincense, borneol, camphor and lithospermum are ground to a particle size of less than 150 microns, then fully stirred with molten white vaseline and cooled to form an ointment.

[0014] As a preferred technical solution of the present invention, the isatis root has the effects of clearing heat and detoxifying, and antiviral, and the addition amount is controlled at 30 to 40 parts; the lithospermum has the effects of cooling blood and detoxifying, and promoting skin regeneration, and the addition amount is controlled at 30 to 35 parts.

[0015] The present invention also provides a method for preparing an external-use medicine for treating herpes, comprising the following steps:

[0016] (1) preparing a disinfectant: drying and crushing scorpions, centipedes, snakes, scutellaria, realgar, and isatis root into coarse powders, adding the powders into white wine with an alcohol content of not less than 65°, sealing and soaking the powders for not less than 25 days, and filtering the supernatant to obtain the disinfectant;

[0017] (2) Preparation of external ointment: Grind fenugreek, frankincense, borneol, camphor, and lithospermum officinale to less than 150 μm, sieve, heat and mix with white vaseline, and cool to room temperature to form an ointment.

[0018] The present invention also provides a method for using the external-use medicine for treating herpes, comprising the following steps:

[0019] Step 1: Use a medical cotton swab dipped in disinfectant to evenly wipe the herpes affected area and the surrounding 2 cm area, once in the morning and once in the evening;

[0020] Step 2: Within 5 minutes after disinfection, acupuncture the Hegu and Ashi points to a depth of 0.5 to 1 cm. Leave the needles in place for 10 to 15 minutes, once a day.

[0021] Step 3: After acupuncture, apply topical ointment to the affected area with a thickness of about 1 mm, twice a day for 4 to 7 days.

[0022] As a preferred technical solution of the present invention, the Hegu point is located between the first and second metacarpal bones on the back of the hand; the Ashi point is the most sensitive tender point of the herpes.

[0023] As a preferred technical solution of the present invention, after 5 to 6 days of continuous treatment, the symptoms of blisters, burning pain, and itching caused by herpes can be significantly alleviated, and the skin can be healed without scars. It is suitable for the auxiliary treatment of viral infectious skin lesions such as herpes simplex and herpes zoster.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] This invention utilizes a scientific combination of various animal-derived medicinal products, mineral-derived medicinal products, and traditional Chinese medicines to create a disinfectant solution with bactericidal and detoxifying properties, and a topical ointment that promotes skin repair. These two components act synergistically on herpes lesions, creating a "detoxification first, then repair" treatment pathway. This treatment approach rapidly resolves itching, dries the skin, forms scabs, and removes scabs, offering the significant advantages of rapid onset and a short treatment cycle. The use of high-concentration liquor as an extraction vehicle significantly improves the extraction efficiency of the active ingredients in the animal-derived medicinal products, resulting in a more concentrated and stable efficacy and enhanced initial intervention capabilities for viral elimination and inflammation relief.

[0026] This invention further incorporates acupuncture into its treatment approach, targeting a combination of Hegu and Ashi points, which have been shown to dredge meridians, regulate immunity, and alleviate neuralgia. This approach, in addition to the effects of topical medications, provides systemic support, significantly improving the control of neuralgia and recurrent herpes. Clinical trials have shown that this combination of acupuncture and treatment is superior to ointment therapy alone in terms of both faster pain relief and better skin recovery, demonstrating the overall advantages of a multi-layered approach combining traditional Chinese and Western medicine.

[0027] Furthermore, the topical preparation of the present invention features a simple process, a wide range of raw material sources, and excellent formulation stability, making it convenient for industrial production, storage, transportation, and promotion. The topical ointment utilizes white vaseline as its base, ensuring excellent skin adhesion and permeability, making it widely applicable for treating herpes on various parts of the body, including the face, trunk, and limbs. The multiple ingredients in the formula exhibit synergistic anti-inflammatory, antiviral, and blood circulation-invigorating and tissue-regenerating effects, effectively reducing the recurrence rate of herpes and sequelae such as pigmentation and scarring, demonstrating excellent safety and market prospects. DETAILED DESCRIPTION

[0028] The technical solutions in the embodiments of the present invention will be described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0029] The present invention relates to an external-use medicine for treating herpes and a preparation method thereof, belonging to the technical field of combining traditional Chinese medicine external treatments with modern pharmaceutical processes. The external-use medicine comprises a disinfectant and an external-use ointment. In practical application, the external-use medicine can achieve rapid intervention and repair of herpes through local application combined with acupuncture.

[0030] 1. Specific preparation method of disinfectant:

[0031] Weigh 40 parts of scorpion, 40 parts of centipede, 40 parts of snake, 40 parts of scutellaria, 40 parts of realgar, 40 parts of isatis root according to the following weight parts, and prepare 450 parts of liquor (with an alcohol content of 65° or above). The specific steps are as follows:

[0032] Scorpions, centipedes, and snakes are dried or shade-dried to remove impurities and then crushed into coarse powder with a particle size of about 1 mm; scutellaria baicalensis, realgar, and isatis root are also dried and crushed into coarse powder for later use.

[0033] Take a clean sealed glass jar and put the above six kinds of medicinal material coarse powder into it in turn.

[0034] Add liquor with a temperature of 65° or above until the herbs are completely submerged and seal.

[0035] Place the container in a cool and ventilated place, away from light at room temperature and soak for 30 days. During this period, shake it manually every 5 days to increase the extraction rate of effective ingredients.

[0036] After the soaking period is expired, filter the residue with a 200-mesh filter cloth, and then further clarify it with filter paper or a microporous membrane to obtain a clear liquid, which is the finished disinfectant and is ready for use.

[0037] 2. Specific preparation method of external use ointment:

[0038] Weigh 160 parts of white vaseline, 55 parts of fenugreek, 32 parts of frankincense, 35 parts of borneol, 22 parts of camphor, and 33 parts of lithospermum officinale according to the following weight parts, and prepare the product as follows:

[0039] Wash fenugreek, frankincense and lithospermum officinale, dry them and grind them into fine powder. The powder particle size is controlled below 150 microns and passed through a 100-mesh sieve for later use.

[0040] Borneol and camphor are volatile crystals, so they should be crushed quickly at low temperature, sealed and stored, and then opened when mixed.

[0041] White vaseline was placed in an 80°C water bath and heated until completely melted.

[0042] In the molten state, slowly add all the powder and stir continuously for 20 minutes under the action of a magnetic stirrer or mechanical stirrer until the mixture is evenly mixed to form a homogeneous paste.

[0043] After naturally cooling to room temperature, the mixture is filled into aluminum tubes or ointment bottles, sealed and stored away from light to obtain a finished external ointment.

[0044] 3. Usage:

[0045] Wipe: Dip a medical cotton swab in disinfectant and evenly wipe the herpes affected area and the surrounding 2 cm area once in the morning and evening;

[0046] Acupuncture: After wiping for 5 minutes, select the Hegu point (located between the first and second metacarpal bones of both hands) and the Ashi point (the most painful point of the herpes affected area) and insert disposable filiform needles to a depth of 0.5 to 1 cm. Leave the needles in for 10 to 15 minutes, once a day.

[0047] Apply ointment: After removing the needle, apply the external ointment to the affected area with a thickness of about 1 mm, covering the entire lesion. Apply once in the morning and evening every day for 5 to 7 consecutive days as a course of treatment.

[0048] Example 1: Standard treatment application for herpes zoster (recommended regimen);

[0049] Patient Information and Condition Description: Patient A, a 32-year-old male, was in good health. Due to continuous overtime work and physical exhaustion, he suddenly developed clusters of erythema on the left side of his lower back, accompanied by a stabbing, burning sensation. Blisters and papules, ranging in diameter from 1 to 5 mm, were visible on the skin surface, some of which had ruptured. He was diagnosed with herpes zoster at the hospital and began treatment on the first day of illness.

[0050] Treatment method: Use the disinfectant prepared by the present invention to apply to the affected area and the surrounding 2 cm area once in the morning and evening every day, with a dosage of about 3 ml / time; perform acupuncture 5 minutes after each application, select the Ashi point (tender point) and Hegu point (between the first and second metacarpal bones on the back of the hand) on the affected side, with a needling depth of 0.7 cm, and retain the needles for 12 minutes; after removing the needles, directly and evenly apply the external ointment to form a drug film about 1 mm thick.

[0051] Efficacy observation and record:

[0052] On the second day, the blisters began to shrink and there was no obvious exudate;

[0053] On the third day, the erythema was significantly lighter and the burning sensation was relieved;

[0054] On the 4th day, a dry scab forms and the pain is reduced to a tolerable range;

[0055] On the 6th day, the scabs began to fall off and the skin surface returned to a smooth surface;

[0056] The treatment ended on the 7th day with no scars or residual pain.

[0057] Summary: The treatment regimen took effect quickly, significantly relieved pain, significantly shortened the course of the disease, and did not cause secondary infection or pigmentation. The patient's subjective evaluation was "significantly better than the previous experience of taking acyclovir."

[0058] Example 2: Facial treatment of herpes simplex;

[0059] Patient information and condition description:

[0060] Patient B, a 28-year-old female teacher, developed itching and burning on the edge of her right upper lip after staying up late for several consecutive nights. Blisters formed the next day, accompanied by slight redness, swelling and tightness. She was diagnosed with a recurrence of herpes simplex type I.

[0061] Treatment:

[0062] Immediately use the external medicine of the present invention, the formula is the same as Example 1. Twice a day, morning and evening, the operation method and time are exactly the same, acupuncture Hegu point and right lip Ashi point local point, each time piercing 0.5 cm, retaining the needle for 10 minutes.

[0063] Efficacy observation and record:

[0064] The itching is relieved on the first day of use;

[0065] On the second day, the top of the blister began to collapse and the tension was relieved;

[0066] On the third day, a crust formed and the erythematous area became smaller;

[0067] On the 5th day, the scab fell off and the lips returned to normal.

[0068] Summary: This case shows that the formula is safe and effective when applied at the mucosal junction, and has a cosmetic effect without pigmentation, and the patient's evaluation is satisfactory.

[0069] Example 3: Non-acupuncture intervention comparison plan;

[0070] Patient information and condition description:

[0071] Patient C, a 43-year-old male, developed herpes zoster (shingles) on the inner side of his right arm. Symptoms included clusters of herpes zoster, surrounding hyperemic bands between blisters, and significant nerve pain. For comparison purposes, this patient only received disinfectant and topical ointment, without acupuncture intervention.

[0072] Treatment method: refer to the method of using the disinfectant and ointment in Example 1, but remove the acupuncture operation, and keep the other frequencies and operations consistent.

[0073] Efficacy observation and record:

[0074] On the second day, the blisters were slightly shriveled, but the erythema was still obvious;

[0075] On the 4th day, scabs began to form, but tenderness still remained around the area;

[0076] On the 6th day, the scab fell off, but the neuralgia still persisted;

[0077] On the 10th day, the neuralgia was relieved and skin pigmentation was obvious.

[0078] In summary, although topical medications still have a certain therapeutic effect when not combined with acupuncture, the effectiveness of herpes intervention is significantly delayed, especially for pain control, which indicates that acupuncture plays a key auxiliary role in this program.

[0079] Comparative Example 1: Treatment with external ointment only

[0080] Patient information and condition description:

[0081] Patient D, female, 25 years old, suffered from perioral herpes simplex with multiple recurrences in the past. Treatment was started 4 hours after the onset of this attack. As a control experiment, only the topical ointment prepared by the present invention was used without disinfectant or acupuncture.

[0082] Treatment method: Apply the paste directly to the affected area after cleaning it every morning and evening, with a thickness of about 1 mm, and use it continuously for 7 days.

[0083] Efficacy observation and record:

[0084] On the third day, the blisters began to dry up, but the itching was still there;

[0085] On the 6th day, the scab falls off and new reddish skin appears;

[0086] On the 9th day, the affected area showed mild pigmentation, and the lip marks persisted;

[0087] On the 11th day, there was a slight relapse in situ, with small blisters forming again.

[0088] Summary: Although the use of topical ointment alone has a certain relief effect, the treatment cycle is long, the recurrence rate is high, and the recovery quality is poor, which cannot meet the clinical goals of rapid repair and prevention of recurrence.

[0089] The contents not described in detail in this specification belong to the prior art known to professional and technical personnel in this field. Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments or to replace some of the technical features therein with equivalents. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A medicine for external use for treating herpes, characterized in that: Includes disinfectant solutions and topical ointments, including: The disinfectant comprises, by weight, 20-50 parts of scorpions, 20-50 parts of centipedes, 20-50 parts of snakes, 20-50 parts of scutellaria baicalensis, 20-50 parts of realgar, 20-50 parts of isatis root, and 300-500 parts of liquor; The external-use ointment comprises, by weight, 100-200 parts of white vaseline, 40-60 parts of fenugreek, 20-40 parts of frankincense, 20-50 parts of borneol, 15-25 parts of camphor and 20-40 parts of lithospermum officinale.

2. The external-use medicine for treating herpes according to claim 1, wherein: The preferred proportion of the disinfectant is: 30-40 parts of scorpions, 30-40 parts of centipedes, 30-40 parts of snakes, 30-40 parts of scutellaria baicalensis, 30-40 parts of realgar, 30-40 parts of isatis root, and 400-450 parts of liquor.

3. The external-use medicine for treating herpes according to claim 1, wherein: The preferred proportion of the external ointment is: 150-180 parts of white vaseline, 50-55 parts of fenugreek, 30-35 parts of frankincense, 30-40 parts of borneol, 20-22 parts of camphor, and 30-35 parts of lithospermum officinale.

4. The external-use medicine for treating herpes according to claim 1, wherein: In the disinfectant, the alcohol content of the liquor is 65° or above. The animal medicinal materials are mixed with the traditional Chinese medicine components and then soaked in a sealed container for 25 to 30 days before the filtrate is taken for use.

5. The external-use medicine for treating herpes according to claim 1, characterized in that: In the external ointment, fenugreek, frankincense, borneol, camphor and lithospermum officinale are ground to a particle size of less than 150 microns, then fully stirred with molten white vaseline and cooled to form an ointment.

6. The external-use medicine for treating herpes according to claim 1, characterized in that: The isatis root has the effects of clearing heat, detoxifying and resisting viruses, and the addition amount is controlled at 30 to 40 parts; the lithospermum erythrorhizon has the effects of cooling blood, detoxifying and promoting skin regeneration, and the addition amount is controlled at 30 to 35 parts.

7. A method for preparing the external-use medicine for treating herpes according to any one of claims 1 to 6, characterized in that: The steps include: (1) preparing a disinfectant: drying and crushing scorpions, centipedes, snakes, scutellaria, realgar, and isatis root into coarse powders, adding the powders into white wine with an alcohol content of not less than 65°, sealing and soaking the powders for not less than 25 days, and filtering the supernatant to obtain the disinfectant; (2) Preparation of external ointment: Grind fenugreek, frankincense, borneol, camphor, and lithospermum officinale to less than 150 μm, sieve, heat and mix with white vaseline, and cool to room temperature to form an ointment.

8. A method for using the external-use medicine for treating herpes according to any one of claims 1 to 6, characterized in that: The following steps are involved: Step 1: Use a medical cotton swab dipped in disinfectant to evenly wipe the herpes affected area and the surrounding 2 cm area, once in the morning and once in the evening; Step 2: Within 5 minutes after disinfection, acupuncture the Hegu and Ashi points to a depth of 0.5 to 1 cm. Leave the needles in place for 10 to 15 minutes, once a day. Step 3: After acupuncture, apply topical ointment to the affected area with a thickness of about 1 mm, twice a day for 4 to 7 days.

9. The method of use according to claim 8, characterized in that: The Hegu point is located between the first and second metacarpal bones on the back of the hand; the Ashi point is the most sensitive tender point on the herpes.

10. The method of use according to claim 8, characterized in that: After 5 to 6 days of continuous treatment, it can significantly relieve the symptoms of blisters, burning pain, and itching caused by herpes, and promote scar-free healing of the skin. It is suitable for the auxiliary treatment of viral infectious skin lesions such as herpes simplex and herpes zoster.