Prepn process of 2-fluoro-5-trifluoromethyl benzyl cyanide

A technology of trifluoromethyl benzene acetonitrile and fluorotrifluorotoluene is applied in the field of preparation of 2-fluoro-5-trifluoromethyl benzene acetonitrile, can solve the problems of high cost, complicated preparation method and the like, achieves high yield, high purity effect

Inactive Publication Date: 2006-03-01
LYNCHEM
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  • Abstract
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Problems solved by technology

[0002] 2-Fluoro-5-trifluoromethyl benzyl nitrile is a new intermediate for the treatment of gynecological

Method used

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  • Prepn process of 2-fluoro-5-trifluoromethyl benzyl cyanide

Examples

Experimental program
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Embodiment

[0015] (1) Preparation of 2-fluoro-5-trifluoromethylbenzyl chloride

[0016] Put 229g of concentrated sulfuric acid into a 250ml four-neck flask, add 24.2g of paraformaldehyde in batches under ice water cooling, control the reaction temperature not to exceed 30°C, and continue stirring for 0.5h after addition. Add 43.5 g of thionyl chloride dropwise within 4 hours at 20-25°C, and continue stirring for 1 hour after the dropwise addition is complete. Add 20.1 g of p-fluorobenzotrifluoride to the reaction flask dropwise within 2 hours at 25-30°C, and react for 4 hours at the same temperature after addition. After the reaction was completed, the mixture was allowed to stand for stratification, and 23.8 g of the upper organic phase was separated.

[0017] Recycle the concentrated sulfuric acid mother liquor after the above reaction, add 4.8g of paraformaldehyde, 9.7g of thionyl chloride, and 20.1g of p-trifluorotoluene, and the other reaction conditions are the same as above to ob...

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Abstract

The present invention discloses the preparation process of 2-fluoro-5-trifluoromethyl benzyl cyanide. The preparation process includes the halogenomethylation of p-fluoro trifluoro toluene to produce 2-fluoro-5-trifluoromethyl benzyl halide, and the nitrilation of 2-fluoro-5-trifluoromethyl benzyl halide to produce 2-fluoro-5-trifluoromethyl benzyl cyanide. The present invention has high yield, low cost and high product purity.

Description

technical field [0001] The present invention relates to the preparation method of 2-fluoro-5-trifluoromethyl benzyl nitrile, particularly relate to the preparation of 2-fluoro-5-trifluoromethyl benzyl nitrile by halomethylation and nitrilation of p-fluorobenzotrifluoride Methods. Background technique [0002] 2-Fluoro-5-trifluoromethylbenzyl nitrile is a new intermediate for treating gynecological diseases and oral contraceptives. The currently disclosed preparation method is cumbersome and costly. Therefore, it is necessary to develop a method for preparing 2-fluoro-5-trifluoromethylbenzylnitrile with high yield and low cost. Contents of the invention [0003] The purpose of the present invention is to provide a kind of high yield, the method for the preparation 2-fluoro-5-trifluoromethyl benzyl nitrile of low cost in view of the deficiencies in the prior art. [0004] To achieve the above object, the method of the present invention comprises the following steps: genera...

Claims

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Application Information

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IPC IPC(8): C07C255/35C07C253/14C07C253/34
Inventor 陈荣业夏赓
Owner LYNCHEM
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