Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Prepn process of 2-fluoro-5-trifluoromethyl benzyl cyanide

A technology of trifluoromethyl benzene acetonitrile and fluorotrifluorotoluene is applied in the field of preparation of 2-fluoro-5-trifluoromethyl benzene acetonitrile, can solve the problems of high cost, complicated preparation method and the like, achieves high yield, high purity effect

Inactive Publication Date: 2006-03-01
LYNCHEM
View PDF0 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] 2-Fluoro-5-trifluoromethyl benzyl nitrile is a new intermediate for the treatment of gynecological diseases and oral contraceptives. The currently disclosed preparation method is cumbersome and expensive

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Prepn process of 2-fluoro-5-trifluoromethyl benzyl cyanide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0015] (1) Preparation of 2-fluoro-5-trifluoromethylbenzyl chloride

[0016] Put 229g of concentrated sulfuric acid into a 250ml four-neck flask, add 24.2g of paraformaldehyde in batches under ice water cooling, control the reaction temperature not to exceed 30°C, and continue stirring for 0.5h after addition. Add 43.5 g of thionyl chloride dropwise within 4 hours at 20-25°C, and continue stirring for 1 hour after the dropwise addition is complete. Add 20.1 g of p-fluorobenzotrifluoride to the reaction flask dropwise within 2 hours at 25-30°C, and react for 4 hours at the same temperature after addition. After the reaction was completed, the mixture was allowed to stand for stratification, and 23.8 g of the upper organic phase was separated.

[0017] Recycle the concentrated sulfuric acid mother liquor after the above reaction, add 4.8g of paraformaldehyde, 9.7g of thionyl chloride, and 20.1g of p-trifluorotoluene, and the other reaction conditions are the same as above to ob...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses the preparation process of 2-fluoro-5-trifluoromethyl benzyl cyanide. The preparation process includes the halogenomethylation of p-fluoro trifluoro toluene to produce 2-fluoro-5-trifluoromethyl benzyl halide, and the nitrilation of 2-fluoro-5-trifluoromethyl benzyl halide to produce 2-fluoro-5-trifluoromethyl benzyl cyanide. The present invention has high yield, low cost and high product purity.

Description

technical field [0001] The present invention relates to the preparation method of 2-fluoro-5-trifluoromethyl benzyl nitrile, particularly relate to the preparation of 2-fluoro-5-trifluoromethyl benzyl nitrile by halomethylation and nitrilation of p-fluorobenzotrifluoride Methods. Background technique [0002] 2-Fluoro-5-trifluoromethylbenzyl nitrile is a new intermediate for treating gynecological diseases and oral contraceptives. The currently disclosed preparation method is cumbersome and costly. Therefore, it is necessary to develop a method for preparing 2-fluoro-5-trifluoromethylbenzylnitrile with high yield and low cost. Contents of the invention [0003] The purpose of the present invention is to provide a kind of high yield, the method for the preparation 2-fluoro-5-trifluoromethyl benzyl nitrile of low cost in view of the deficiencies in the prior art. [0004] To achieve the above object, the method of the present invention comprises the following steps: genera...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C255/35C07C253/14C07C253/34
Inventor 陈荣业夏赓
Owner LYNCHEM
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com