52 results about "Propanethiol" patented technology

The invention discloses a porefilling electroplating leveling agent, a preparation method thereof and an electroplating liquid using the porefilling electroplating leveling agent, and relates to the technical field of electroplating. The porefilling electroplating leveling agent comprises ingredients: 3-(dimethylamino)-1- propanethiol, piperazine and binary epoxy compound, wherein the molar mass ratio of the 3-(dimethylamino)-1- propanethiol, the piperazine and the binary epoxy compound is 1-3: 2-4: 4-6; and the binary epoxy compound has the following structural formula (see in the specification), wherein R is a linking group of a non-epoxy group. According to the porefilling electroplating leveling agent, a functional group containing sulfur atoms is added into leveling agent molecules, so that the interaction between the leveling agent molecules and an accelerator and an inhibitor is improved, the leveling agent, the accelerator and the inhibitor can better interwork, and the prepared electroplating liquid has an excellent porefilling performance.

The invention discloses a preparation method of ticagrelor. The preparation method comprises the following steps of: carrying out a cyclization reaction between 5-amino-1,4-di-substituted-1,2,3-triazole (II) and a dialkyl carbonate (III), thereby obtaining 9-substituted-2,6-dihydroxy-8-azaguanine (IV), chlorinating the intermediate (IV) to obtain 9-substituted-2,6-dichloro-8-azaguanine (V), carrying out an amination reaction between the intermediate (V) and trans-(1R, 2S)-2-(3,4-difluorophenyl) cyclopropylamine (VI) to generate 9-substituted-6-amino substituent-2-chloro-8-azaguanine (VII), and carrying out a propylthiolation reaction between the intermediate (VII) and propanethiol (VIII) to obtain the ticagrelor (I). The preparation method disclosed by the invention is simple in process, and high in chemical and chiral purity, and provides a new preparation way for industrial production of the ticagrelor.

The invention relates to a polyurethane type high-refraction optical resin monomer containing sulfur and a preparation method of the polyurethane type high-refraction optical resin monomer. The preparation method includes: using mercaptoethanol as the raw material to synthesize a 2, 3-dimercapto ethyl sulfo-propanethiol monomer through sulfo-polyol and sulfo-polymercaptan, and allowing the 2, 3-dimercapto ethyl sulfo-propanethiol monomer to have a polymerization addition reaction with isocyanate to prepare an optical resin lens with high refraction rate and high light transmittance.\The polyurethane type optical resin monomer prepared by the method is high in purity, and the monomer and the lens are high in refraction rate, high in light transmittance, and the like. The light transmittance of the monomer is not smaller than 89%, the refraction rate of the monomer is not smaller than 1.66, the abbe number of the monomer is not smaller than 31, and the yellow index of the monomer is not larger than 0.8. The light transmittance of the lens is not smaller than 90%, the refraction rate of the lens is not smaller than 1.67, the yellow index of the lens is not larger than 1.55, and the surface hardness of the lens is 2H.

The invention discloses a strain for degrading ethanethiol as well as a culture method and application of the strain. The strain is named as Pseudomonas sp. WL2; the preservation number is CGMCC NO. 7898; the strain is preserved in the Common Microorganism Center of the Chinese Microorganism Strain Preservation Administration Committee(CGMCC), and the preservation date is 8th June, 2013. The strain for degrading ethanethiol is an aerobiotic Gram-negative bacterium, which can be grown by taking ethanethiol as a sole carbon source and energy, and can be thoroughly mineralized into CO2 and H2O. Under a pure culture condition, the strain is capable of degrading ethanethiol under the conditions that the temperature is 25-30 DEG C and the pH is 6-8. The strain has good substrate adaptive capacity and substrate extensiveness, and is capable of degrading propanethiol and methanol. The strain establishes the basis for industrial application in treating sulfur-containing stink organic waste gases by using a biologic method.

The invention discloses a surface-enhanced Raman scattering substrate material, a preparation method and an application thereof. The substrate material is a three-layer composite structure: the lower layer is an Au (at) Ag nanoparticle monofilm; the middle layer is a propanethiol molecular layer modified on the Au (at) Ag film; and the upper layer is a polydimethylsiloxane film of 200-400 nm thick. According to the three-layer composite structural substrate material, the polydimethylsiloxane film enriches mononuclear aromatics gaseous molecules in flowing gas through physical action, propanethiol adsorbs the molecules onto the surface of the Au (at) Ag film to carry out enhanced detection. Thus, toxic atmospheric pollutants can be effectively enriched, fixed and detected. Especially for detection of methylbenzene, benzene and xylene in a flowing gaseous phase, detection signal intensity is enhanced by more than 50 times. The invention provides a more sensitive new method for detection of relevant pollutants in industrial waste gas and in the atmospheric environment.

Provided are a zinc sulfide nano particle with sulfydryl surface finish and a preparation method thereof. A solvent heat synthesis method is adopted, thiourea is selected to serve as a sulfur source, zinc acetate is a zinc source, and N,N-dimethylformamide serves as a reaction medium. 2,3-dimercaprol ethyl sulfo-propanethiol (BES) serves as dressing agent ligand which is mixed with zinc and the sulfur source according to certain proportion, reaction is carried out for 6-12 hours at the temperature of 120-160 DEG C through condensation backflow, the zinc sulfide nano particle with the sulfydryl surface finish is synthetized in situ, particles are even in dispersion, and average size is within 100nm. The zinc sulfide nano particle provided with the sulfydryl surface finish and obtained by using the preparation method is high in interface refractive index, good in dispersibility and moderate in reaction, contribute to in situ polymerization compound with macromolecules, can serve as an electroluminescence material, is particularly suitable to compound with optic plastic to improve refractive index, and serves as optical elements such as a lens.

This invention has disclosed a pseudomonas putida strain as well as its microbial inoculum and application. Such strain is named as Pseudomonas putida S-1, which was preserved at China Center for Type Culture Collection (CCTCC) on Sep. 25, 2013 with the deposit number of CCTCC NO: M2013444. The strain of this invention takes isopropanol, ethanal, dipropyl disulfide, diethyl disulfide and propanethiol as the sole carbon source for effective degradation of substrate simultaneously with the energy growth. Furthermore, it can obtain a perfect growth in different cultivation modes owing to high substrate tolerance, which has laid down a solid foundation for engineering application for elimination of VOCs contained exhaust gas by means of biological purification.

The invention provides a novel preparation method of albendazole. According to the invention, a novel synthetic route of albendazole is provided, wherein 2-nitro-5-chloroaniline is used as a startingmaterial and is subjected to reactions of substitution, condensation, reduction and cyclization to obtain high-purity albendazole. The method is characterized in that: the 2-nitro-5-chloroaniline is subjected to substituted reaction, and is subjected to condensation reaction with halogenated n-propane to obtain 2-nitro-5-albendazole aniline, which avoids the use of propanethiol with a high price and a stimulating odor. The use of a high-risk hydrogenation reduction process is avoided, a vulcanization alkali reduction process which is cheap and easily available in raw materials is used, a set of non-toxic treatment schemes for reducing layered waste water are provided, and meanwhile, secondary sodium thiosulfate can be obtained and the waste is turned into wealth. According to the method, the yield is high, the safety risk is low, the industrial production is facilitated, the content of the prepared albendazole is high, the content of single impurities is small, and the latest standardssuch as the US Pharmacopeia and the European Pharmacopoeia are met.

The invention discloses a transparent polyurethane optical material and a preparation method thereof. The transparent polyurethane optical material is prepared by taking isocyanate and polymer polyol as reactants and adding substances such as an additive for reaction. 1,4-bis (isocyanate methyl ester) cyclohexane, isophorone diisocyanate and p-phenylene diisocyanate are selected for the isocyanate, polytetrahydrofuran glycol and polycarbonate polyol are selected for the polymer polyol, and 2,3-bis (2-mercaptoethylthio)-1-propanethiol and 5-ethylpropylthio-1,3,4-thiadiazole-2-thiol are selected for the additive; an accelerant is prepared from polymethylhydrosiloxane and aniline substances through reaction, and 4-(10H-phenothiazin-10-yl) aniline and 4-(10H-phenothiazin-10-yl) aniline are selected for the aniline substances; and the finally prepared polyurethane material has the advantages of higher tensile strength and hardness, favorable mechanical properties, no color, transparency, higher refractive index and favorable optical properties, and is particularly suitable for being used as an optical material.

The invention relates to the technical field of a high polymer material antistatic agent, and particularly relates to a quaternary ammonium salt hyperbranched antistatic agent. Propargyl alcohol reacts with succinic anhydride so as to obtain a modified monomer R1, the R1 reacts with 3-(dimethylamino)-1-propanethiol so as to obtain a modified monomer R2, the R2 reacts with a hydroxyl-terminated hyperbranched polymer so as to obtain a dimethyl amine-terminated hyperbranched structure, and then the dimethyl amine-terminated hyperbranched structure reacts with alkyl chloride so as to obtain the quaternary ammonium salt hyperbranched antistatic agent. The molecules of the antistatic agent contain more effective active groups, the utilization rate of the molecules is relatively high, the surface water absorbability of the antistatic agent in a substrate is relatively strong, and correspondingly the antistatic agent has a relatively good antistatic effect; the antistatic agent has relatively good compatibility with a medium and very good dispersibility.

The invention relates to a detection method for metabolites in urine. The method includes (1) a step of removing impurities from a urine sample, namely a step of removing urea, sulfur and phosphorus and precipitating protein to obtain urine C; (2) a drying step, namely a step of drying the urine C to obtain urine residues D; (3) a step of oximation, namely a step of subjecting beta-carbonyl in acid or alcohol metabolites in the urine residues D to oximation by utilizing an oximation agent to obtain urine E; (4) a step of derivatization, namely a step of subjecting the urine E to derivatization with an derivatization agent to obtain a urine sample F to be detected, with the derivatization agent being an agent mixture comprising a silanization agent, a catalyst and a catalyst stabilizer, and with the catalyst stabilizer being selected from dithioerythritol, dithiothreitol, 1-propanethiol, ethanethiol and 2-mercaptoethanol; and (5) a step of detection, namely a step of detecting the urine sample F to be detected by adopting a gas chromatography-mass spectrography process. The method has advantages of a low sample using amount, simple pretreatment, short time, capability of detecting a plurality of varieties of compounds, rapid and accurate result analysis, and the like.

The invention discloses a flame-retardant soft printing adhesive. The flame-retardant soft printing adhesive is prepared from the following raw materials in parts by weight: 20-25 parts of polyester acrylate, 2-3 parts of OP-10, 12-14 parts of butyl acrylate, 6-8 parts of methyl methacrylate, 4-5 parts of acrylonitrile, 1-2 parts of N-hydroxymethyl acrylamide, 6-8 parts of ethylene glycol, 2-3 parts of dicyclopentadiene, 13-14 parts of glycidyl methacrylate, 45-50 parts of urethane acrylates, 2-3 parts of crylic acid 1-2,4,6-tribromophenyl, 2-3 parts of 3-(Trimethoxysilyl)propanethiol, 10-12 parts of trifluoroethyl methacrylate, 1-2 parts of styrene phenol polyoxyethylene ether, 1-2 parts of ammonium persulfate, 4-5 parts of accessory ingredients and 70-80 parts of water. The flame-retardant soft printing adhesive, disclosed by the invention, is excellent in flame-retardant effect and has the characteristics of high transparency, water resistance, softness and moderate viscosity; a coating with the adhesive adopts a simple printing process, guarantees bright colors and clear outlines of fabrics, causes less pollution and has wide development prospect.

The invention belongs to the technical field of organic sulfide detection, and particularly relates to a detection method of propanethiol. The detection method comprises the following steps that S1, AuNPs-Ag wires are prepared, wherein the AuNPs-Ag wire preparation process comprises the steps of cleaning of silver wires, corrosion of the silver wires and modification of the silver wires; S2, the propanethiol is detected, wherein the propanethiol detection process comprises the steps of extraction and surface enhanced Raman detection. According to the detection method of the propanethiol, an SPME-SERS coupling technique is adopted, the technology is simple, the complex sample pretreatment process can be reduced or even omitted, the analysis time can be shortened, the detection sensitivity is high, the limit of detection to the propanethiol can reach 10-13 M, and the detection method of the propanethiol is suitable for in-situ rapid analysis of field spots.

Disclosed in the present invention is a method for preparing Ticagrelor (I), comprising the following steps: a cyclization reaction of 5-amino-1,4-di-substituted-1,2,3-triazole (II) and dialkyl carbonate (HI), to obtain 9-substituted-2,6-dihydroxy-8-azapurine (IV); chlorination of intermediate (IV), to obtain 9-substituted-2,6-dichloro-8-azapurine (V); an amination reaction of intermediate (V) and trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine (VI) generates 9-substituted-6-amino-substituted-2-chloro-8-azapurine (VII); and a propanethiolation reaction of intermediate (VII) and propanethiol (VIII), to obtain Ticagrelor (I). The preparation method is simple in process, has a high chemical and chiral purity and provides a new preparation method for industrializing Ticagrelor. In addition, also provided in the present invention are intermediates of Ticagrelor and a preparation method thereof, wherein raw materials of the preparation method are easily available, the conditions thereof are mild, and the yield thereof is high.

The invention discloses a rubber anti-reversion agent composition. The composition is prepared by using the following raw materials, by weight, 50-100 parts of natural rubber, 20-50 parts of carbon black, 15-45 parts of white carbon black, 3-7 parts of zinc fatty acid, 5-8 parts of disodium dithiosulfate, 8-12 parts of zinc aromatic acid, 7-15 parts of citraconyl imine, 2-5 parts of an accelerant NS, and 4-8 parts of propanethiol. The rubber anti-reversion agent composition has the advantages of stable performances, good quality, improvement of the anti-reversion capability of rubber, and guarantee of the stress at definite elongation of the rubber compound under over vulcanization conditions.

The invention discloses a hole-filling electroplating leveling agent, a preparation method thereof and an electroplating solution using the hole-filling electroplating leveling agent, and relates to the technical field of electroplating. The hole-filling electroplating leveling agent includes ingredients 3-(dimethylamino)-1-propanethiol, piperazine, binary epoxy compound, and the 3-(dimethylamino)-1-propanethiol The molar mass ratio of mercaptan, piperazine and binary epoxy compound is 1~3:2~4:4~6; described binary epoxy compound has the following structural formula: wherein, R is the connection of non-epoxy group group. The hole-filling electroplating leveling agent of the present invention improves the interaction between the leveling agent molecule and the accelerator and inhibitor by introducing a sulfur atom-containing functional group into the leveling agent molecule, so that the three types of additives can better cooperate with each other , so that the prepared electroplating solution can achieve excellent hole filling performance.

The invention discloses a loofah sponge saddle for a long-distance bicycle and a preparation method. The composition comprises raw materials in parts by weight as follows: 100-200 parts of loofah sponge fibers, 4-6 parts of trimethyl propanethiol, 5-9 parts of cyclohexane dicarboxylic ester, 30-50 parts of chitosan, 50-70 parts of bamboo charcoal micro-powder, 2-4 parts of nano silver, 50-100 parts of rubber powder, 40-50 parts of negative-ion polypropylene staple fibers, 50-100 parts of resin with the viscosity of 3000-3200, 30-50 parts of waterproof resin slurry, 3-5 parts of citric acid, 2-6 parts of a silane coupling agent and a proper amount of deionized water. A trimethyl propanethiol-modified loofah sponge fiber high-polymer material is matched with the negative-ion polypropylene staple fibers, the chitosan, the bamboo charcoal micro-powder and the nano silver and combined with the resin, the high-breathability, high-elasticity, high-buffering and wear-resistant loofah sponge saddle for the bicycle is prepared, and the comfort feeling of a rider is enhanced.

The invention provides a tinning brightener and a preparing method thereof. Raw materials include glutaraldehyde, dyhydroxy propanethiol, cinnamyl aldehyde, alkylphenol ethoxylates and water. The rawmaterials include 55-80 parts of glutaraldehyde, 60-90 parts of dyhydroxy propanethiol, 5-10 parts of cinnamyl aldehyde, 55-85 parts of alkylphenol ethoxylates and 300-400 parts of water. Through cooperation of mixing, cooling, additive adding, carrier brightener adding and product forming work processes, the situation that Sn2+ is likely to be oxidized by an anode during electrolysis is preventedthrough dyhydroxy propanethiol, and long-term stability of a plating solution is improved; meanwhile, the chemical activity of glutaraldehyde carbonyl is particularly high, meanwhile, the Sn2+ adsorption capability is improved, and then brightness of the tinning brightener is improved; meanwhile, influences are generated to glutaraldehyde adsorption from cinnamyl aldehyde, the potential, adsorbedto the surface of an electrode, of the glutaraldehyde becomes narrow, accordingly, fine crystalline particles are generated, an auxiliary function is achieved for clad layer brightness increasing, and brightness of the tinning brightener is improved.

The invention relates to a detection method for metabolites in urine. The method includes (1) a step of removing impurities from a urine sample, namely a step of removing urea, sulfur and phosphorus and precipitating protein to obtain urine C; (2) a drying step, namely a step of drying the urine C to obtain urine residues D; (3) a step of oximation, namely a step of subjecting beta-carbonyl in acid or alcohol metabolites in the urine residues D to oximation by utilizing an oximation agent to obtain urine E; (4) a step of derivatization, namely a step of subjecting the urine E to derivatization with an derivatization agent to obtain a urine sample F to be detected, with the derivatization agent being an agent mixture comprising a silanization agent, a catalyst and a catalyst stabilizer, and with the catalyst stabilizer being selected from dithioerythritol, dithiothreitol, 1-propanethiol, ethanethiol and 2-mercaptoethanol; and (5) a step of detection, namely a step of detecting the urine sample F to be detected by adopting a gas chromatography-mass spectrography process. The method has advantages of a low sample using amount, simple pretreatment, short time, capability of detecting a plurality of varieties of compounds, rapid and accurate result analysis, and the like.

The invention discloses a graphene dispersed slurry which consists of the following raw material formula components in parts by mass: 20-25 parts of micro-crystal graphene, 4-5 parts of nano aluminum oxide, 3-4 parts of nano silicon dioxide, 3-5 parts of carbon fiber, 8-10 parts of polyvinyl alcohol, 3-5 parts of zinc stearate, 2-3 parts of sodium polyacrylate, 3-4 parts of sodium lignin sulfonate, 3-5 parts of sodium dodecyl sulfonate, 5-6 parts of propanethiol, 3-5 parts of gamma-trimethoxysilylpropanethiol, 2-3 parts of tetrabutyl titanate, 3-4 parts of carbon black, 3-5 parts of hydroxyethyl cellulose, 4-5 parts of titanium dioxide, 5-6 parts of polyester resin, 6-8 parts of gum dammar, 3-5 parts of talcum powder, 35-40 parts of methyl isobutyl ketone and 35-40 parts of propylene glycol monomethyl ether acetate. By adopting the graphene dispersed slurry, the problem that aggregate is hard to disperse can be well solved, and the phenomenon that dispersed graphene is aggregated again as nanoparticles are not stable can be avoided.

The present invention relates to a pyridazinone compound and a synthesis method thereof, wherein the general formula of the compound is defined in the specification, R<1> is C1-C4 alkyl or halogen, R<2> is C1-C4 alkyl or halogen, R<3> is linear chain fatty amine or cyclic amine or propylthio or aromatic methoxy, and R<4> is halogen or propylthio. The preparation method comprises: carrying out a Friedel-Crafts reaction on halogenated acetyl halide and benzene to synthesize alpha-halogenated acetophenone, carrying out a substitution reaction on the alpha-halogenated acetophenone and 4,5-dichloro-3(2H)-pyridazinone to synthesize an intermediate, and carrying out a substitution reaction on the generated intermediate and a nucleophilic reagent such as fatty amine or cyclic fatty amine or propanethiol under the catalysis of an alkaline reagent to synthesize the pyridazinone compound. Compared to the method in the prior art, the method of the present invention has advantages of simple process, good repeatability, simple and easily-available raw materials, wide application range and good application prospect.

The invention relates to a method for recycling disulfide during production of a low-sulfur MTBE (methyl tert-butyl ether) product. The method comprises the following steps: feeding mixed C-4 into a cutting tower, reflowing based on partial light C-4 from the tower top as a liquid phase, and feeding the residual light C-4 as feedstock into a MTBE reaction system to obtain an MTBE product; extracting maleic, n-pentane, ethanethiol, isopropyl mercaptan and n-propanethiol from a side line opening, wherein the discharge at the tower bottom is sulfur mixture; and sending disulfide to a sulfide fractionating tower, separating dimethyl dithio from the tower top, and separating diethyl dithio mixture from the tower bottom. The MTBE product produced by the invention is high in purity and low in sulfur content, and only contains 2-3mg / kg in general; the method has the features of simple process, advanced technology, simple and convenient control operation, low energy consumption and strong practicability.

The invention belongs to the field of medicinal chemistry synthesis and discloses a synthetic method of 2-(3,3,3-trifluoropropylthio) adenosine. The method comprises the following steps: firstly performing nucleophilic substitution between 2-Chloroadenine (as shown in a formula I) as a raw material and tetraacetylribofuranose in a first solvent under a function of catalyst SnCl4 to obtain a compound (as shown in a formula II); performing hydrolysis reaction on the compound (as shown in the formula II) in a second solvent under a function of alkali a to obtain a compound (as shown in formula a III); finally performing nucleophilic substitution on the compound (as shown in the formula III) and 3,3,3-trifluoro-propanethiol under a function of alkali b to obtain a compound (as shown in a formula IV), namely 2-(3,3,3-trifluoropropylthio) adenosine. The synthetic method in the invention is simple in lines, high in yield and low in cost, and raw materials are low in cost and easy to obtain.

The invention provides a novel preparation method of albendazole. According to the invention, a novel synthetic route of albendazole is provided, wherein 2-nitro-5-chloroaniline is used as a startingmaterial and is subjected to reactions of substitution, condensation, reduction and cyclization to obtain high-purity albendazole. The method is characterized in that: the 2-nitro-5-chloroaniline is subjected to substituted reaction, and is subjected to condensation reaction with halogenated n-propane to obtain 2-nitro-5-albendazole aniline, which avoids the use of propanethiol with a high price and a stimulating odor. The use of a high-risk hydrogenation reduction process is avoided, a vulcanization alkali reduction process which is cheap and easily available in raw materials is used, a set of non-toxic treatment schemes for reducing layered waste water are provided, and meanwhile, secondary sodium thiosulfate can be obtained and the waste is turned into wealth. According to the method, the yield is high, the safety risk is low, the industrial production is facilitated, the content of the prepared albendazole is high, the content of single impurities is small, and the latest standardssuch as the US Pharmacopeia and the European Pharmacopoeia are met.

The invention relates to a durian flavor essence, which is composed of the following components: propanethiol; 3-hydroxy-2-butanone; hexadecanoic acid; octadecanoic acid; 2-methyl-ethyl butyrate; 2-methyl-butyric acid methyl butyrate; ethyl propionate; ethyl acetate; ethyl butyrate; propyl caproate; ethyl heptanoate; ethyl octanoate; -1,2,4-Trithiolane; Methyl 3-Methylthiopropionate; Diethyldisulfide; Propyl Trisulfide; Diallyl Sulfide; Ethanethiol; Propylene Glycol; Durian Extract. Durian flavor essence has a natural, rich and non-irritating durian flavor, which satisfies people's pursuit of flavor and expands the use range of durian; at the same time, the product is resistant to high temperature and can effectively supplement the loss of durian flavor during thermal processing, thereby enhancing the food's quality. Durian characteristic flavor.

The invention relates to a polyurethane type high-refraction optical resin monomer containing sulfur and a preparation method of the polyurethane type high-refraction optical resin monomer. The preparation method includes: using mercaptoethanol as the raw material to synthesize a 2, 3-dimercapto ethyl sulfo-propanethiol monomer through sulfo-polyol and sulfo-polymercaptan, and allowing the 2, 3-dimercapto ethyl sulfo-propanethiol monomer to have a polymerization addition reaction with isocyanate to prepare an optical resin lens with high refraction rate and high light transmittance.\The polyurethane type optical resin monomer prepared by the method is high in purity, and the monomer and the lens are high in refraction rate, high in light transmittance, and the like. The light transmittance of the monomer is not smaller than 89%, the refraction rate of the monomer is not smaller than 1.66, the abbe number of the monomer is not smaller than 31, and the yellow index of the monomer is not larger than 0.8. The light transmittance of the lens is not smaller than 90%, the refraction rate of the lens is not smaller than 1.67, the yellow index of the lens is not larger than 1.55, and the surface hardness of the lens is 2H.

2,3-epoxy-2-propylsulfone-5,8-dimethoxy-1,4-naphthoquinone, a preparation method thereof, and a medicine containing the same; it belongs to the technical field of medicine. Its structural formula is: The method of the present invention: 1. Dissolve 5,8-dimethoxy-1,4 naphthoquinone in methanol, add 1-propanethiol, react at room temperature, then add sodium dichromate and concentrated sulfuric acid , continue to react, then extract with dichloromethane and saturated saline, dry over anhydrous sodium sulfate, filter, and concentrate to dryness; 2, then dissolve in chloroform, continue to add 3-chloroperoxybenzoic acid, react at room temperature, react Add 5% NaHCO after complete 3 After neutralizing the excess m-chloroperoxybenzoic acid in the solution, the reaction was terminated, extracted with dichloromethane and saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated to dryness. Application of the compound and the pharmaceutical composition of the present invention in the preparation of medicines for treating liver cancer.

The invention relates to the technical field of a high polymer material antistatic agent, and particularly relates to a quaternary ammonium salt hyperbranched antistatic agent. Propargyl alcohol reacts with succinic anhydride so as to obtain a modified monomer R1, the R1 reacts with 3-(dimethylamino)-1-propanethiol so as to obtain a modified monomer R2, the R2 reacts with a hydroxyl-terminated hyperbranched polymer so as to obtain a dimethyl amine-terminated hyperbranched structure, and then the dimethyl amine-terminated hyperbranched structure reacts with alkyl chloride so as to obtain the quaternary ammonium salt hyperbranched antistatic agent. The molecules of the antistatic agent contain more effective active groups, the utilization rate of the molecules is relatively high, the surface water absorbability of the antistatic agent in a substrate is relatively strong, and correspondingly the antistatic agent has a relatively good antistatic effect; the antistatic agent has relatively good compatibility with a medium and very good dispersibility.

The invention belongs to the technical field of organic sulfide detection, and particularly relates to a detection method of propanethiol. The detection method comprises the following steps that S1, AuNPs-Ag wires are prepared, wherein the AuNPs-Ag wire preparation process comprises the steps of cleaning of silver wires, corrosion of the silver wires and modification of the silver wires; S2, the propanethiol is detected, wherein the propanethiol detection process comprises the steps of extraction and surface enhanced Raman detection. According to the detection method of the propanethiol, an SPME-SERS coupling technique is adopted, the technology is simple, the complex sample pretreatment process can be reduced or even omitted, the analysis time can be shortened, the detection sensitivity is high, the limit of detection to the propanethiol can reach 10-13 M, and the detection method of the propanethiol is suitable for in-situ rapid analysis of field spots.