The invention provides a novel preparation method of
albendazole. According to the invention, a novel synthetic
route of
albendazole is provided, wherein 2-nitro-5-chloroaniline is used as a startingmaterial and is subjected to reactions of substitution, condensation, reduction and cyclization to obtain high-purity
albendazole. The method is characterized in that: the 2-nitro-5-chloroaniline is subjected to substituted reaction, and is subjected to
condensation reaction with halogenated n-
propane to obtain 2-nitro-5-albendazole
aniline, which avoids the use of
propanethiol with a high price and a stimulating
odor. The use of a high-risk hydrogenation reduction process is avoided, a
vulcanization alkali reduction process which is cheap and easily available in raw materials is used, a set of non-toxic treatment schemes for reducing layered waste water are provided, and meanwhile, secondary
sodium thiosulfate can be obtained and the waste is turned into wealth. According to the method, the yield is high, the
safety risk is low, the industrial production is facilitated, the content of the prepared albendazole is high, the content of single impurities is small, and the latest standardssuch as the US Pharmacopeia and the European
Pharmacopoeia are met.