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34 results about "Cytimidine" patented technology
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Methods for preparing 5-Aza-2'-deoxycytidine and intermediate product thereof
InactiveCN101570559AHigh yieldHigh puritySugar derivativesDrug compositionsSeparation technologyDisplacement reactions
The invention relates to methods for preparing 5-Aza-2'-deoxycytidine and an intermediate product thereof. The method for preparing the preparing 5-Aza-2'-deoxycytidine comprises the following steps: a compound (shown in formula 2) is hydrolyzed under alkaline matter to remove acyl-oxygen protecting group, a diastereomeric compound (shown in formula 3) is obtained, and then the diastereomeric compound is separated by a general separation technology to obtain an isomer. The invention also relates to a compound (shown in formula 2) used as the intermediate product and a preparation method thereof, wherein the preparation method comprises the following steps: 5-Aza cytimidine is activated by a silanization method, and then makes displacement reaction with a compound (shown in formula 4), and further removes the protecting group to obtain the compound (shown in formula 2). The preparation method has simpler process, good reproduction quality and little toxicity and is suitable to the industrialized production; and meanwhile, used raw materials and reagent are easy to obtain.
Owner:NANJING CHANGAO PHARMA SCI & TECH CO LTD
Method for synthesizing cytimidine
The invention discloses a method for synthesizing cytimidine, which comprises the following steps: performing a reaction of a reactant (1) and a reactant (2) to acquire cytimidine under the action of sodium methoxide, wherein the reactant (1) is 3-alkoxy acrylonitrile and / or 3, 3-alkoxy propionitrile, and the reactant (2) is carbamide. The method is characterized in that a solid catalyst is added in the reaction. The catalyst is the solid catalyst, such as one or more of acidic alumina, solid super acid, zinc oxide and a molecular sieve. The method can achieve the effects of shortening the reaction time, improving the yield and reducing the price of raw materials.
Owner:上海普渡生化科技有限公司
Process for quickly detecting DNA methylation
InactiveCN101285096AGood repeatabilitySave desalination timeMicrobiological testing/measurementDNA methylationSilica gel
The invention relates to the medical biology detection technical field and discloses a method for quickly detecting DNA methylation. Aiming at the disadvantages of the prior method, the method provided by the invention improves the following three aspects: 1. catalyst TAC and guanidine hydrochloride are added to accelerate the modification reaction; 2. short-time high-temperature melting is performed during the modification reaction for times so as to fully expose basic groups to transform cytimidine which is not made from methylation modification to sulfonated uracil; 3. aiming at fussy dialysis desalination steps after the modification, when a modified DNA product is purified, the modified DNA product is combined into a glass fiber membrane or pellosil or other pillars for washing desalination, then is treated by sulfated reagent and eluted, thereby obtaining a methylated PCR template which can be directly used for PCR augmentation and greatly saves desalination time. The method has low cost, short detection time and good repetitiveness.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Preparation method of lamivudine and intermediate thereof
ActiveCN101597281AOperational securityThe process steps are simpleOrganic chemistryAntiviralsCytimidineStereochemistry
The invention discloses a preparation method of lamivudine and an intermediate thereof; (2R,5R)-5-hydroxyl-[1,3]oxathiolane-2-carboxylicacid(2S-isopropyl-5R-methyl-1R-cyclohexyl)ester, the structure of which is shown in formula (II) is used as a raw material; acyl compound, the structure of which is shown in formula (III) is obtained by the acylation reaction of acyl; acyl compound (III) reacts with cytimidine, the structure of which is shown in formula (IV) by condensation reaction to prepare the intermediate of lamivudine (V) and the intermediate is reducted to obtain lamivudine (I). The invention is characterized by safe and reliable operation, simplified process, low production cost and the like, thus being suitable for industrialized production.
Owner:SHANDONG WEIFANG PHARMA FACTORY
Sulfur-containing ring-free nucleosides phosphonate analogue and preparation method thereof
InactiveCN101143879ARaw materials are easy to getSimple and fast operationGroup 5/15 element organic compoundsBulk chemical productionCytimidineAcyclic nucleoside
The present invention discloses a sulfur-containing acyclic nucleoside phosphonate analog and a preparation method, which belongs to the technical fields of medicines and chemistry. The structural formula of the compound of the present invention is shown on the right, wherein, B is one of adenine, guanine, cytimidine, uracil and thymine and the substituted base, X is one of hydrogen, hydroxyl, fluorin, methoxyl and azido, and the carbon atom shown as * is a chiral carbon, which has two types of chiral enantiomers, the R-configuration and the S-configuration. The compound of the present invention can apply the market-purchased three carbon chiral material and can be prepared by a fundamental chain containing a three carbon alkyl side chain, which is obtained by a reaction between the material and a base, protection by an active group, the introduction of sulfur atoms, the linkage of a phosphonic acid-containing side chain and the removal of the protective group. The synthesis method of the present invention has the advantages of easy acquirement of materials, mild reaction conditions and convenient operation.
Owner:SHANGHAI JIAO TONG UNIV
Preparation method for cytidine
InactiveCN102690311AEasy to get materialsLow costSugar derivativesSugar derivatives preparationChemistryTetra
The invention discloses a preparation method for cytidine. The method includes following steps: firstly, subjecting cytosine to silanization protection by tert-butyl dimethyl chloro silane; secondly, reacting with tetra-o-acetyl-d-ribose; thirdly, obtaining crude cytidine by ammonolysis of the reactant; and fourthly, adding the crude cytidine to ethanol for refinement, heating, refluxing and dissolving while stirring and adding water, devitrifying after cooling, separating to obtain solid, and drying to obtain the cytidine. The preparation method for the cytidine is simple in process route, low in cost, low in environmental pollution and safe in production, is a route suitable for industrial production and has wide application prospect.
Owner:SHANGYU HUAKE CHEM +1
Process for making 5-azacytosine nucleosides and their derivatives
ActiveUS8212021B2High boiling pointIncrease polarityEsterified saccharide compoundsOrganic active ingredientsSilylation5-azacytosine
Owner:SCINOPHARM TAIWAN LTD
Synthetic method of decitabine
ActiveCN102212097AIncrease contentReduce the difficulty of purificationSugar derivativesOrganic-compounds/hydrides/coordination-complexes catalystsCytimidineEthyl acetate
The invention relates to the field of medicament synthesis and discloses a synthetic method of decitabine. The method comprises the following specific steps of: undergoing a condensation reaction on 2,4-di-(trimethyl silicane)-5-aza-cytimidine and chloro-ribose under the catalytic action of nitrophenol; and hydrolyzing in an alkaline environment for removing acetyl to generate decitabine. In the synthetic method of decitabine, disclosed by the invention, nitrophenol is taken as a catalyst, the ratio of a beta configurational isomer in the obtained chloro-ribose aza-cytimidine is large, the content of beta configurational decitabine generated after hydrolysis is high, the purifying difficulty of decitabine is lowered, and the purity of a decitabine finished product is increased. During purification, ethyl acetate is used instead of methanol or ethanol, so that the influence of methanol or ethanol on the purity of the decitabine finished product at the purifying stage is avoided; and moreover, the synthetic method has the advantages of cheap reagents, less reaction steps, mild reaction condition and contribution to industrial production.
Owner:CHONGQING SINTAHO PHARM CO LTD
Alumina nano channel film, and preparation method and application method thereof
ActiveCN104713924AImprove performanceSimple preparation processSurface reaction electrolytic coatingMaterial electrochemical variablesPower flowSingle strand
The invention discloses an application method for an alumina nano channel film. The method comprises the following steps: determining a first current corresponding to the alumina nano channel film modifying single-stranded deoxyribonucleic acid containing cytimidine and thymine by using a picoammeter method; soaking the alumina nano channel film modifying the single-stranded deoxyribonucleic acid containing cytimidine and thymine in a solution containing mercury ions Hg2+ and / or silver ions Ag+ for preset time, and then taking the film out of the solution; determining a second current corresponding to the alumina nano channel film modifying the single-stranded deoxyribonucleic acid containing cytimidine and thymine by using the picoammeter method; and according to the first current and the second current, determining whether the alumina nano channel film modifying the single-stranded deoxyribonucleic acid containing cytimidine and thymine can specifically identify the mercury ions and the silver ions. The invention also discloses the alumina nano channel film and a preparation method thereof.
Owner:BEIHANG UNIV
Method for predicting tumor metastasis and invasion capacity in vitro and nucleotide fragments
The invention discloses a method for predicting malignant tumor metastasis and invasion capacity in vitro, which comprises the following steps of: (a) extracting DNA (Deoxyribonucleic Acid) from surgical incisal margins or tumor-adjacent tissues; (b) detecting the methylating degree of cytimidine in 5'- end CpG island of seroreaction factor gene DNA sequence in DNA obtained in the step (a); and (c) when the seroreaction factor gene DNA sequence with methylated cytimidine in the 5'-end CpG island is detected in the step (b), presuming that the tissue being detected has the capacity of resisting malignant tumor metastasis and invasion. The invention also provides four artificial nucleotide fragments. The inventor of the invention, for the first time, find that the metastasis and invasion capacity of malignant tumors can be rapidly and accurately predicted by detecting whether the seroreaction factor gene DNA sequence with methylated cytimidine in CpG island exists or not in the tissue being detected. Besides, the nucleotide fragments provided in the invention can be used for accurately and rapidly detecting the methylation of cytimidine in the CpG island in the seroreaction factor gene DNA sequence.
Owner:BEIJING CANCER HOSPITAL PEKING UNIV CANCER HOSPITAL
Gamma-cytidine-5'-disodium triphosphate crystal compound, and preparation method and drug composition of crystal compound
ActiveCN103044509AOperating conditions are easy to controlSuitable for industrial productionOrganic active ingredientsNervous disorderPharmacyPhosphoric acid
The invention relates to a gamma-cytidine-5'-disodium triphosphate crystal, and a preparation method, a drug composition, and a drug preparation of the crystal. The solubility and the stability of the crystal are better than those of a substance in the prior art, and the crystal is more beneficial for pharmacy and long-term storage. The preparation is particularly suitable for being prepared into an injection and a powder injection.
Owner:宁辉
Novel synthesis process of capecitabine
ActiveCN102140124ASimple post-processingAvoid pollutionSugar derivativesOrganic-compounds/hydrides/coordination-complexes catalystsCytosineBiochemical engineering
The invention discloses a novel synthesis process of capecitabine and discloses a preparation method of 2',3'-O-isopropylidene-5'-deoxy-5-fluoro-N4-(carbopentyloxy)cytimidine (compound V) serving as an intermediate. Meanwhile, the invention discloses a preparation method for obtaining capecitabine by removing a protective group from the compound serving as a raw material under the catalytic action of iodine. The method has the advantages of readily available raw materials, environmental friendliness, high yield and no heavy metal pollution, and is suitable for industrial production.
Owner:湖南欧亚药业有限公司
Clone method of SGAE label 3' end cDNA segment
InactiveCN101514353AUniform lengthOvercome the problem of low initial quantityFermentationReverse transcriptaseCytimidine
The invention relates to a clone method of SGAE label 3' end cDNA segment, belonging to the field of biotechnology. The method comprises the following steps: reverse transcription is carried out on all mRMAs by utilizing the decorated oligo(dT16), 3-5 cytimidine basic groups are added the 3' end of a first cDNA which is synthesized by murine reverse transcriptase, complementary strand of the first cDNA is synthesized by primers, a pair of primers are synthesized according to the known sequence at the two ends of the cDNA for PCR augmentation, and all the cDNAs are concentrated; the cDNA concentrated in the step one is taken as a template, specific segments containing tag are cloned by adopting semi-nested PCR. By adopting the invention, the specific segments containing tag label can be more easily obtained, the process is simpler and the cost is lower.
Owner:SHANGHAI JIAO TONG UNIV
5-azacytidine compound and preparation method thereof
PendingCN110746476AGuaranteed purityLess impuritiesSugar derivativesSugar derivatives preparationCombinatorial chemistryStructural formula
The invention relates to a 5-azacytidine compound and a preparation method thereof. The structural formula of the 5-azacytidine compound is shown in a formula I (shown in the specification). The compound is obtained from 5-azacytosine as a starting material by upper protection, condensation, deprotection, recondensation and a deprotection rection. Through studies of related substances, recognitionand control of an impurity profile in the 5-azacytidine compound are strengthened, the quality of a finished product is advantageously controlled, and a guarantee is provided for the safety of clinical medication. The synthesis process is simple in operation, good in yield and purity, and is environment friendly.
Owner:JIANGSU HANSOH PHARMA CO LTD
Method for synthesizing emtricitabine intermediate
ActiveCN101391997AOperational securityThe reaction steps are simpleOrganic chemistryState of artEmtricitabine
The invention discloses a synthetic method of emtricitabine intermediates, namely, (2R, 5S)-5-(5'-fluoro-cytimidine-1-group)-1, 3-oxathiolane-2-carboxylic acid-L-menthyl ester having the structural formula of (VI), (2R, 5S)-5-hydroxy-1, 3-oxathiolane-2-carboxylic acid-L-menthyl ester having the structural formula of (III) is taken as raw material to obtain chloro compounds having the structural formula of (IV) by chlorination reaction, then the chloro compounds (IV) are treated with condensation and hydrolyzation reactions with N, O-bis(trimethoxy)5-flurocytosin having the structural formula of (V), thus obtaining the (2R, 5S)-5-(5'-fluoro-cytimidine-1-group)-1, 3-oxathiolane-2-carboxylic acid-L-menthyl ester (VI). The invention uses bis(trichloromethyl) carbonic ester to replace the thionyl chloride in the prior art so as to be taken as a chlorination reagent, thus having the advantages of safe and reliable operation and environmental protection.
Owner:JIANGSU COBEN PHARMA CO LTD +1
Method for synthesizing cytidine
ActiveCN112480197ALow costNovel design routeSugar derivativesSugar derivatives preparationLewis acid catalysisCatalytic effect
The invention discloses a method for synthesizing cytidine, and belongs to the field of nucleoside synthesis in organic chemistry. Cyanoacetaldehyde urea is used as a raw material, is subjected to silylation and then is condensed with tetraacetylribose under the catalytic action of Lewis acid to obtain an intermediate, and then cyclization and deprotection are completed through a one-pot reactionunder the action of sodium alcoholate to obtain cytidine. The method is convenient in raw material source and simple to operate, the three steps of reaction processes are continuously carried out, andrecrystallization purification only needs to be carried out when a final product is obtained; compared with the traditional process, the process operation is simple, the yield is stable, and the final alkaline hydrolysis and condensation processes are carried out by a one-pot method, thereby facilitating industrial large-scale production.
Owner:TUOXIN GROUP +1
2',3'-O-carbonyl-5'-deoxy-5-fluoro-N4-[(pentyloxy)carbonyl]cytidine synthesis method
ActiveCN103524583ARaw materials are easy to getSimple methodSugar derivativesSugar derivatives preparationOrganic solventReaction temperature
The invention discloses a 2',3'-O-carbonyl-5'-deoxy-5-fluoro-N4-[(pentyloxy)carbonyl]cytidine synthesis method. According to the method, 2,3-di-O-acetyl-5'-deoxy-5-fluoro-N4-[(pentyloxy)carbonyl]cytidine is adopted as a raw material, and is dissolved by using an organic solvent; organic alkali is added; CO2 is delivered in; and a reaction is allowed under a reaction temperature controlled at 0-50 DEG C and a reaction time controlled at 1-24h. According to the method, an intermediate of a capecitabine production process is used for preparing capecitabine impurity C2',3'-O-carbonyl-5'-deoxy-5-fluoro-N4-[(pentyloxy)carbonyl]cytidine. The raw materials are easier to obtain, and the method is more simplified.
![2',3'-O-carbonyl-5'-deoxy-5-fluoro-N4-[(pentyloxy)carbonyl]cytidine synthesis method](https://images-eureka.patsnap.com/patent_img/c06c38de-05b9-4511-a7a8-d855e4fab1c4/2013105233412100002DEST_PATH_IMAGE001.PNG "2',3'-O-carbonyl-5'-deoxy-5-fluoro-N4-[(pentyloxy)carbonyl]cytidine synthesis method")
![2',3'-O-carbonyl-5'-deoxy-5-fluoro-N4-[(pentyloxy)carbonyl]cytidine synthesis method](https://images-eureka.patsnap.com/patent_img/c06c38de-05b9-4511-a7a8-d855e4fab1c4/2013105233412100002DEST_PATH_IMAGE004.PNG "2',3'-O-carbonyl-5'-deoxy-5-fluoro-N4-[(pentyloxy)carbonyl]cytidine synthesis method")
![2',3'-O-carbonyl-5'-deoxy-5-fluoro-N4-[(pentyloxy)carbonyl]cytidine synthesis method](https://images-eureka.patsnap.com/patent_img/c06c38de-05b9-4511-a7a8-d855e4fab1c4/38479DEST_PATH_IMAGE002.PNG "2',3'-O-carbonyl-5'-deoxy-5-fluoro-N4-[(pentyloxy)carbonyl]cytidine synthesis method")
Owner:SHANDONG BOYUAN PHARM CO LTD
Synthesis process of uridine
ActiveCN113735926AThe synthesis process is simpleReduce manufacturing costSugar derivativesSugar derivatives preparationOrganic acidCytosine
The invention discloses a synthesis process of uridine, and belongs to the technical field of organic synthesis. The process comprises the following steps of uniformly mixing cytidine serving as a main raw material with water, controlling the temperature to be 10-60 DEG C, respectively adding a nitrous acid reagent and inorganic acid or organic acid, carrying out heat preservation reaction for 1-10 hours, ending the reaction after the raw material is added, controlling the pH value to be 1-4 after the reaction is completed, carrying out reduced pressure concentration to obtain a uridine concentrated solution, dropwise adding an alcohol solvent into the uridine concentrated solution, and crystallizing to obtain the product uridine. The process is easy to operate, thorough in reaction and high in reaction speed, and the synthesis period is greatly shortened. In addition, the conversion rate of the process is up to 90% or above, the yield is up to 80% or above, and the purity is greater than 99.5%.
Owner:江苏香地化学有限公司
Nucleoside derivative modified aptamer R50
The invention relates to a nucleoside derivative modified nucleic acid aptamer, the sequence of which comprises a sequence as shown in SEQ NO: 1, at least one nucleotide of the nucleic acid aptamer is replaced by a nucleoside derivative, and / or the tail end of the nucleic acid aptamer is connected and modified by the nucleoside derivative; preferably, the nucleoside derivative is a thymine nucleoside derivative or a cytidine nucleoside derivative.
Owner:RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Method for synthesizing emtricitabine intermediate
ActiveCN101391997BOperational securityThe reaction steps are simpleOrganic chemistryEmtricitabineCarboxylic acid
The invention discloses a synthetic method of emtricitabine intermediates, namely, (2R, 5S)-5-(5'-fluoro-cytimidine-1-group)-1, 3-oxathiolane-2-carboxylic acid-L-menthyl ester having the structural formula of (VI), (2R, 5S)-5-hydroxy-1, 3-oxathiolane-2-carboxylic acid-L-menthyl ester having the structural formula of (III) is taken as raw material to obtain chloro compounds having the structural formula of (IV) by chlorination reaction, then the chloro compounds (IV) are treated with condensation and hydrolyzation reactions with N, O-bis(trimethoxy)5-flurocytosin having the structural formula of (V), thus obtaining the (2R, 5S)-5-(5'-fluoro-cytimidine-1-group)-1, 3-oxathiolane-2-carboxylic acid-L-menthyl ester (VI). The invention uses bis(trichloromethyl) carbonic ester to replace the thionyl chloride in the prior art so as to be taken as a chlorination reagent, thus having the advantages of safe and reliable operation and environmental protection.
Owner:JIANGSU COBEN PHARMA CO LTD +1
A kind of method of synthesizing cytidine nucleoside
ActiveCN108409818BNovel design routeEasy to operateSugar derivativesSugar derivatives preparationCytimidineSilyl ether
The invention discloses a method of synthesizing cytidine and belongs to the field of nucleoside synthesis of organic chemistry. The method comprises the following reaction steps of taking N4-acylcytosine as a raw material and trimethylsilyl acetate and B(C6F5)3 as a catalyst, performing condensation on the N4-acylcytosine, the trimethylsilyl acetate, the B(C6F5)3 and tetraacetyl ribose, and thenperforming acid or alkaline deprotection to obtain cytosine. By adopting the method, the whole process only needs two-step reaction, a great quantity of silylamine is avoided from being used to perform trimethylsilyl etherification on the N4-acetylcytosine and then perform condensation with the tetraacetyl ribose, a stannic chloride condensating agent is cancelled, the cost of the raw materials islowered, and the total yield reaches 80 percent.
Owner:TUOXIN GROUP +1
Gamma-cytidine-5'-disodium triphosphate crystal compound, and preparation method and drug composition of crystal compound
ActiveCN103044509BOperating conditions are easy to controlSuitable for industrial productionOrganic active ingredientsNervous disorderPharmacyPhosphoric acid
The invention relates to a gamma-cytidine-5'-disodium triphosphate crystal, and a preparation method, a drug composition, and a drug preparation of the crystal. The solubility and the stability of the crystal are better than those of a substance in the prior art, and the crystal is more beneficial for pharmacy and long-term storage. The preparation is particularly suitable for being prepared into an injection and a powder injection.
Owner:宁辉
Application of cytidine as metabolic marker
The invention belongs to the technical field of metabolic markers, and relates to application of cytidine serving as a metabolic marker for predicting death caused by acute and severe radioactive intestinal injuries. With the application of the cytidine serving as the metabolic marker for predicting death caused by acute and severe radioactive intestinal injuries of the invention, death caused byacute and severe radioactive intestinal injuries can be better predicted.
Owner:SUZHOU UNIV
Preparation method of lamivudine and intermediate thereof
ActiveCN101597281BOperational securityThe process steps are simpleOrganic chemistryAntiviralsCarboxylic acidCytimidine
The invention discloses a preparation method of lamivudine and an intermediate thereof; (2R,5R)-5-hydroxyl-[1,3]oxathiolane-2-carboxylicacid(2S-isopropyl-5R-methyl-1R-cyclohexyl)ester, the structure of which is shown in formula (II) is used as a raw material; acyl compound, the structure of which is shown in formula (III) is obtained by the acylation reaction of acyl; acyl compound (III) reacts with cytimidine, the structure of which is shown in formula (IV) by condensation reaction to prepare the intermediate of lamivudine (V) and the intermediate is reducted to obtain lamivudine (I). The invention is characterized by safe and reliable operation, simplified process, low production cost and the like, thus being suitable for industrialized production.
Owner:SHANDONG WEIFANG PHARMA FACTORY
Modified nucleic acid and application thereof
PendingCN114807154AImprove stabilityProlong half-life in vivoOrganic active ingredientsSsRNA viruses positive-senseDiseaseCytimidine
The invention provides a modified nucleic acid and application thereof, and belongs to the technical field of nucleic acid modification, the modified nucleic acid comprises uridine, cytidine, adenine nucleoside, guanine nucleoside and chemically modified nucleoside; the chemically modified nucleoside comprises one or more of chemically modified uridine nucleoside, chemically modified cytidine nucleoside, chemically modified adenine nucleoside and chemically modified guanine nucleoside. The modified nucleic acid disclosed by the invention is high in stability, low in immunogenicity and long in in-vivo half-life period; the modified nucleic acid provided by the invention can be used as a diagnostic agent or a therapeutic agent, is applied to diagnosis and treatment of diseases, overcomes the defects of low stability, high immunogenicity, short in-vivo half-life period, need of repeated administration in a short time, high cost and the like compared with the existing nucleic acid in a natural state, and reduces the application cost while enhancing the curative effect of a nucleic acid drug.
Owner:SHENZHEN RHEGEN BIOTECHNOLOGY CO LTD
Novel preparation method of nucleoside modified 5'-dmtr-2'-eoe-5-me-cytidine nucleoside
ActiveCN109456376BHigh feasibilityReduce the difficulty of purificationSugar derivativesSugar derivatives preparationEthyl groupCytosine nucleoside
The invention relates to a preparation method of a novel nucleoside modifier 5'-DMTr-2'-ethoxyethyl (EOE)-5-Me-cytidine nucleoside. The method of the present invention uses the novel nucleoside modified substance 5'-DMTr-2'-EOE-thymidine as the starting material, and through processes such as reaction with chlorinating agent and triazole, ammonolysis treatment, etc., the yield is high. , to generate another novel nucleoside modification 5'-DMTr-2'-EOE-5-Me-cytidine nucleoside with high selectivity. The method of the invention can easily and economically synthesize the novel nucleoside modified 5'-DMTr-2'-EOE-5-Me-cytidine nucleoside in large quantities.
Owner:SHANGHAI ZHAOWEI TECH DEV +1
Method for enzymatic synthesis of nicotinamide cytosine dinucleotide and application thereof
ActiveCN112695063AImprove responseMild conditionsTransferasesFermentationEnzymatic synthesisMetabolite
The invention relates to a method for enzymatic synthesis of nicotinamide cytosine dinucleotide and application thereof. A nicotinamide mononucleotide adenosine transferase mutant is used as a catalyst to catalyze coupling reaction of nicotinamide mononucleotide and cytidine triphosphate, so as to prepare nicotinamide cytidine dinucleotide. The coding gene of the nicotinamide mononucleotide adenosine transferase mutant is expressed in microbial cells, engineering bacteria synthesize nicotinamide cytosine dinucleotide by using endogenous metabolites, and the intracellular nicotinamide cytosine dinucleotide can be used as a coenzyme to selectively mediate redox reaction and improve the yield of target metabolites. In one typical example, the yield of L-malic acid is increased by 79%. In another typical example, the conversion rate of producing D-lactic acid from L-malic acid is increased by 2.4 times.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Novel synthesis process of capecitabine
ActiveCN102140124BSimple post-processingAvoid pollutionSugar derivativesOrganic-compounds/hydrides/coordination-complexes catalystsCytosineBiochemical engineering
Owner:湖南欧亚药业有限公司
A kind of method for extracting cytosine nucleoside from fermentation broth
ActiveCN107827943BReduce pollutionThe extraction process is simple, safe and efficientSugar derivativesSugar derivatives preparationCytosine nucleosideCytimidine
The invention discloses a method for extracting cytidine nucleoside from fermentation liquid. In the method, the fermented liquid is separated from solid and liquid to obtain filtrate, and the filtrate is subjected to nanofiltration to obtain nanofiltration liquid, and the nanofiltration liquid is decolorized through macroporous adsorption resin The decolorized solution is obtained, and the decolorized solution is concentrated and crystallized to obtain the product.
Owner:台州市厚普生物科技有限公司 +1
Method for preparing 5-aza-2'-deoxycytidine and its intermediates
Owner:NANJING CHANGAO PHARMA SCI & TECH CO LTD
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