A kind of method for extracting cytosine nucleoside from fermentation broth

Abstract

The invention discloses a method for extracting cytidine nucleoside from fermentation liquid. In the method, the fermented liquid is separated from solid and liquid to obtain filtrate, and the filtrate is subjected to nanofiltration to obtain nanofiltration liquid, and the nanofiltration liquid is decolorized through macroporous adsorption resin The decolorized solution is obtained, and the decolorized solution is concentrated and crystallized to obtain the product.

Description

A kind of method for extracting cytosine nucleoside from fermentation broth technical field [0001] The present invention relates to a method for extracting cytosine nucleoside from fermentation broth. Background technique [0002] Cytosine riboside (cytosine riboside) is also known as cytidine (cytidine). The use of nucleoside products is highly professional, It is an indispensable raw material in biomedical research and a basic element for the preparation of biological drugs. Cytidine is mainly used in the production of Intermediates of anti-tumor and anti-viral drugs. In recent years, the United States has been in the field of anti-viral, anti-tumor, and AIDS drug cytarabine. (Ara‑CR), cyclocytidine (Cyclo C), cytidine triphosphate (CTP), citicoline (CDP‑Choline) and other nucleic acid drugs In terms of the main raw materials, it has shown an irreplaceable role. With the in-depth development of such drugs, the demand for pyrimidine nucleosides has increased. It ...

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Problems solved by technology

[0003] At present, most cytidine nucleosides are chemically synthesized, and the separation and extraction of cytidine nucleosides from fermentation broth has not been reported in the literature.