96 results about "Cytidine triphosphate" patented technology

The invention relates to a high abrasion-resistant tread rubber for a middle and long distance highway transportation type radial tire and a producing method of the tread rubber, wherein the producing method comprises the following processing steps:(1) first-stage mixing: adding nature rubber SMR20,butadiene rubber, butadiene styrene rubber and peptizer into a mixing chamber for raw rubber plastication, then adding N234 carbon black, white carbon black, a silane coupling agent, zinc oxide, stearic acid, a dispersing agent and a plasticizer for mixing, finally adding N234 carbon black for mixing, and obtaining the first-stage original rubber by discharging rubber; (2) standing for first time; (3) second-stage mixing: adding first-stage original rubber, the N234 carbon black, an anti-aging agent RD, an anti-aging agent 4020 and microcrystalline wax into an internal mixer for mixing, and obtaining second-stage original rubber by discharging rubber after the mixing; (4) standing for second time; and (5) final mixing: adding the second-stage original rubber, sulphur, an accelerator NS and a scorch retarder CTP (cytidine triphosphate) into the mixing chamber for mixing, and obtaining the tread rubber by discharging rubber. In the invention, the abrasion resistance of middle and long distance highway transportation type radial tires can be greatly enhanced, the producing and working efficiency is enhanced, and energy is greatly saved.

Flavivirus, rhabdovirus and paramyxovirus infections may be treated by administering an inhibitor of the enzyme dihydroorotate dehydrogenase such as 6-fluoro-2-(2′-fluoro-1,1′-biphenyl-4-yl)-3-methyl-4-quinolinearcarboxylic acid sodium salt (Brequinar). A synergistic effect can be obtained if an interferon such as interferon α2, interferon α8 or interferon β, or an inhibitor of a second enzyme selected from inosine monophosphate dehydrogenase, guanosine monophosphate synthetase, cytidine triphosphate synthetase and S-adenosylhomocysteine hydrolase, is also administered.

A cytidine disodium triphosphate perfusion is prepared from cytidine disodium triphosphate, stabilizer chosen from guanidine carbonate, arginine and tween-80, pH regulator, isotonic regulator and the water for injection through dissolving, filtering, pouring in bottles and sterilizing.

The invention discloses a prescription of a cytidine disodium triphosphate freeze-dried powder-injection for injection and a process for preparing the same. The powder-injection consists of an active component of cytidine disodium triphosphate, a stabilizer of guanidine carbonate and/or arginine, an excipient of mannitol or dextran 40, as well as a pH regulator, wherein the weight ratio of the active component to the stabilizer to the excipient is 1:0.5-5:0.5-5, and the weight ratio of the guanidine carbonate to the arginine in the stabilizer is 2-4:1; and the addition of the pH regulator is standardized to control the pH value of the powder-injection between 6.0 and 6.5. The process for preparing the cytidine disodium triphosphate freeze-dried powder-injection comprises the steps of dissolving the prescription quantity of each component into certain amount of injection water, and then performing filtration, filling, pre-freezing, and freeze drying. The cytidine disodium triphosphate freeze-dried powder-injection and the method improve the stability of the active component, and solve the problems that the cytidine disodium triphosphate in the prior freeze-dried powder-injection is decomposed to a large extent in the process of preservation and the effectiveness of the medicament is reduced. Besides, the cytidine disodium triphosphate freeze-dried powder-injection and the method improve the using safety of the medicament and are advantageous for the long-time storage of medicaments.

The invention relates to an antiscroching additive of rubber and also relates to a preparation method of rubber antiscroching agent CTP (cytidine triphosphate) pre-dispersion masterbatch. The method comprises the following steps: weighting antiscroching agent CTP, carrier masterbatch, adhesive dispersant EVA (ethylene vinyl acetute), a lubricant, processing oil, inorganic filler and coupling agent according to certain weight proportions in turn to perform feed preparation, adding the carrier masterbatch, the adhesive dispersant EVA and the lubricant in a mixer for heating and mixing; then fully mixing rubber antiscroching agent CTP and processing oil, adding the mixture to mix; adding the inorganic filler and the coupling agent during the mixing period; and performing extrusion and pelletization on the mixed rubber material to obtain particles with the corresponding specification. By adopting the method, dust pollutions can be reduced, the working environment can be improved, the accuracy of the formula can be increased, the dispersibility of the CTP active ingredients can be increased, the intermiscibility of CTP and rubber can be increased, and the product has high cost performance, wide application range and wide market prospect.

The present invention relates to an antiviral composition comprising any one selected from the group consisting of chlorine, phosphocholine, cytidine triphosphate, CDP-choline, phosphorylcholine, and phosphatidylcholine. The antiviral composition is harmless to the human body and exhibits an excellent inhibitory effect on virus proliferation. Therefore, it can be applied to a pharmaceutical composition for preventing or treating viral diseases as well as a health functional food, a quasi-drug composition, and a feed composition for preventing or ameliorating viral diseases.

The invention relates to a novel active cytidine disodium triphosphate compound and a pharmaceutical composition thereof. The powder X-ray diffraction determination method indicates that the cytidine disodium triphosphate compound has feature diffraction peaks at 7.43 degrees, 9.88 degrees, 12.52 degrees, 14.92 degrees, 16.37 degrees, 19.58 degrees, 21.88 degrees, 23.57 degrees, 25.26 degrees, 30.69 degrees, 33.05 degrees and 34.32 degrees in the X-ray powder diffractogram represented as the diffraction angle 2theta+/-0.2 degrees. The cytidine disodium triphosphate compound provided by the invention has obviously higher stability, and can not change after being stored for a long time, thereby greatly enhancing the medication security of the patient.

The invention relates to a high-energy substance for preventing and treating a neurodegenerative disease of old people. The high-energy substance comprises one or more of compounds and derivatives of the compounds of phosphoenolpyruvic acid, creatine phosphoric acid, acetyl coenzyme A, adenosine triphosphoric acid, L-carnitine, s-adenosylmethionine, guanosine triphosphate, cytidine triphosphate, pyrophosphoric acid, 1,3-diphosphoglycerate and succinyl coenzyme A. The high-energy substance has the benefits as follows: the high-energy substance is used for treating the neurodegenerative disease of the old people, particularly the aged population, so as to delay and prevent dementia; and the high-energy substance is proved to be a novel medicine which is reasonable, safe and economical and used for treating the neurodegenerative disease, particularly senile dementia.

The invention relates to a manufacturing method of disodium cytidine triphosphate, which comprises the following steps: proceeding enzymatic conversation with CMP material; proceeding ion exchange column chromatography; separating and purifying. The enzymatic conversation reaction principle is that: brewers' yeast gets the needed enzyme liquid of the enzymatic conversation reaction; brewers' yeast produces a plurality of biological enzyme as sugar glycolysis enzyme and phosphorylase with high sugar glycolysis ability; the biological energy produced by glycolysis glucose with sugar glycolysis enzyme is transferred to cytidine monophosphate by ATP; cytidine monophosphate and phosphate radical combines to form cytidine triphosphate with the effect of phosphorylase. The method shapes low cost, simple operation, high production, high product purity by optimization, which comprises the following steps: getting enzyme liquid; proceeding enzymatic conversation by adding the main material cytidine monophosphate, monobasic potassium phosphate of proper quantity and glucose; getting product by deposition, ion exchange column chromatography, segregation, purification, refining and vacuum drying.

The invention relates to a cable material, and in particular relates to a modified low-temperature-resistant fluorine rubber cable material. The cable material is prepared from the following raw materials in parts by weight: 55 to 60 parts of fluorine rubber 246, 6 to 8 parts of benzyl triphenyl phosphorus chloride, 18 to 24 parts of ethylene vinyl acetate copolymer, 18 to 23 parts of calcium carbonate, 3 to 4 parts of stearic acid, 5 to 9 parts of naphthenic oil, 3 to 4 parts of colza oil, 4 to 5 parts of dibutyl ester, 2 to 3 parts of calcium oxide, 3 to 4 parts of zinc oxide, 0.1 to 0.5 part of scorch retarder CTP (Cytidine Triphosphate), 2 to 3 parts of sulphur, 1 to 2 parts of accelerant DM, 3 to 5 parts of propanediol sebacate polyester, 6 to 8 parts of inositol hexaphosphate, 10 to 12 parts of iron oxide red, 34 to 38 parts of N339 carbon black, 14 to 18 parts of N550 carbon black, 1 to 2 parts of anti-aging agent RD and 4 to 5 parts of auxiliary agent. The modified cable material has the advantages of low-temperature resistance, aging resistance, good chemical stability and the like by improving the characteristics of the traditional fluorine rubber cable material. Meanwhile, the cost of the cable material is lowered. Thus, the modified cable material can meet the use requirements of a specific occasion. In addition, the modified cable material is harmless to environments and human bodies. The modified cable material provided by the invention has broad market prospect.

The invention relates to the technical field of rubber, and in particular relates to an ageing-resistant tire belt rubber composition. Based on 100 parts by weight of natural rubber, the ageing-resistant tire belt rubber composition also contains 40-50 parts of carbon black, 5-15 parts of white carbon black, 6-10 parts of zinc oxide, 1.0-2.5 parts of age resister 4020, 1.0-3.0 parts of binding agent B-20-S, 1.0-3.0 parts of binding agent HMT (Hexamethylenetetramine), 0.5-1.5 parts of cobalt decanoate, 1.0-4.0 parts of zinc borate, 4.0-7.0 parts of insoluble sulfur, 1.0-2.0 parts of vulcanization accelerator and 0.2 part of scorch retarder CTP (Cytidine Triphosphate). The ageing resistance of a belt rubber material is improved by using the zinc borate. The zinc borate is a multifunctional boron-containing fire retardant which is capable of generating a glassy film after being heated and is coated on a polymer to play roles of insulating heat and blocking oxygen and particularly increasing the binding power between a steel wire and the rubber under various ageing conditions and prolonging the service life of a tire.

The invention relates to the field of PS/CTP printing and particularly relates to a calcium remover for PS (Poly Styrene) plate/CTP(Cytidine Triphosphate) plate developing machine and a preparation method of the calcium remover. The calcium remover is prepared from the following raw materials in parts by weight: 10-12 parts of phosphoric acid, 4-6 parts of sulfamic acid, 12-15 parts of citric acid, 1-3 parts of thiourea, 1-3 parts of sodium hydroxy cellulose, 60-80 parts of deionized water, 0.2-0.5 part of pumice powder of which the granularity is 150-400 meshes, 1-2 parts of sodium oleate, 1-3 parts of sodium dodecylbenzenesulfonate and 1-3 parts of additives. According to the calcium remover, a clean and wide-range mixed acid solution is prepared from phosphoric acid, sulfamic acid, citric acid and the like, the calcium hardened layer can be quickly disintegrated, since the solution also has a certain viscosity, the fall-off calcareous layer can be bonded so that the post-cleaning is more convenient; since pumice powder is added, the solution has a certain friction force when the solution is used for scrubbing so as to accelerate fall-off and disintegration of the calcareous layer; in combination with the additives and other components, the calcium remover has strong cleaning capability and is easily cleaned and no damage on the surface of the treated rubber roller is caused and the inking does not be affected.

The invention discloses a sizing material of a stator rubber sleeve for a pre-stressed vacuum grouting pump. The sizing material comprises the following raw materials by weight: 95 to 105 parts of natural rubber, 4 to 6 parts of isoprene rubber, 0.04 to 0.06 parts of butadiene rubber, 1.1 to 1.3 parts of styrene-butadiene rubber, 2 to 4 parts of zinc oxide, 0.3 to 0.5 parts of stearic acid, 0.3 to 0.6 parts of sulfur, 0.2 to 0.4 parts of antiagers DPPD (Diphenyl-P-Phenylene Diamine), 8 to 12 parts of carbon black N339, 0.1 to 0.3 parts of accelerating agents M, 3 to 5 parts of Rhine wax, 0.2 to 0.3 parts of antiscorcher CTP (cytidine triphosphate), and 4 to 6 parts of cottonseed oil. When the sizing material is prepared, a part of formula raw materials is processed through sizing materialplastication at first as required, then other formula materials are added for sizing material mixing, and a vulcanization system is added and is processed through thin-passing for 5 to 7 times finally. Rubber damping products that are produced according to the rubber formula achieve favorable heat-proof aging performance and excellent tear resistance, and also achieve excellent dynamic fatigue resisting performance.

The invention discloses a preparation method of alpha-2,3-sialyllactulose. The method comprises the following steps: dissolving lactulose, sodium cytidine triphosphate and sialic acid in ultrapure water according to certain proportions, adjusting the pH value to 8.5 by using 3mol/L of NaOH, and adding 1mol/L of Tris-HCl with the pH value of 8.5; putting the above obtained mixture in a 37DEG C air bath oscillator, and reacting the mixture for 18-30h; detecting the reaction degree through adopting silica gel thin-layer chromatography (TLC), wherein a TLC developing solvent comprises n-propanol, methanol and water according to a ratio of 5:2:1; adding isopyknic 95% ethanol to a reaction solution obtained after completing the reaction of lactulose, uniformly mixing the reaction solution with ethanol, allowing the obtained mixed solution to stand in a 4DEG C refrigerator for 30min, centrifuging the obtained solution at 7000r/min for 30min, and carrying out rotary evaporative concentration on the obtained supernatant; and purifying the obtained concentrate by using a silica gel chromatographic column, and freeze-drying the purified concentrate to obtain a pure product.

The present invention relates to an escherichia coli mutant strain with high cytidine production and a method for fermentation production of cytidine, and belongs to the technical field of fermentation. The escherichia coli mutant strain is obtained by mutagenic screening and has the following characteristics: 1, alanine at 182nd position of carbamyl phosphate synthetase is mutated to valine, andserine at 948th position is mutated to phenylalanine; 2, isoleucine at 86th position, glycine at 93rd position and cysteine at 109th position of aspartic acid carbamoyl transferase regulatory subunitare deleted; 3, asparagine at 72nd position of uridine kinase is mutated to alanine and aspartic acid at 159th position is mutated to asparagine; and 4, aspartic acid at 147th position of cytidine triphosphate synthase is mutated to glutamic acid, and glutamic acid at 149th position is mutated to alanine. The mutant strain is fermented in a 50-L fermentation tank, cytidine yield reaches (90 plus or minus 2) g/L, sugar-acid conversion rate reaches (30 plus or minus 1)%, and the cytidine yield and sugar-acid conversion rate are both the highest values reported.

The invention discloses special protection glue for PS/CTP (Polystyrene/Cytidine Triphosphate) printing plates. The special protection glue is prepared from the following component raw materials in parts by weight: 3-4 parts of Arabic gum, 2-3 parts of polyethylene glycol, 3-4 parts of sodium carboxymethyl cellulose, 1-1.5 parts of polyvinyl alcohol, 1-2 parts of assistant and 85-90 parts of deionized water. The special protection glue is prepared by adding the raw material components in hot water in a reaction kettle, and fully stirring and filtering. The special protection glue for the PS/CTP printing plates has good leveling property and strong protection ability and prolongs the service life of printing plates, and a smooth protection film can be formed by a quite small dosage.

The invention provides a preparation method of a cytidine disdoium triphosphate freeze-dried powder injection. The preparation method comprises the following steps of: (a) mixing cytidine disdoium triphosphate, an excipient with first water for injection, and adjusting the pH value to obtain mixed solution A; and (b) mixing the mixed solution A with second water for injection, and filtering, freezing and drying in sequence so as to obtain the cytidine disdoium triphosphate freeze-dried powder injection, wherein the mass ratio of the first water for injection to the second water for injection is 6:(3-5). Compared with the prior art, the preparation method provided by the invention can be used for effectively controlling the content of impurities in the cytidine disdoium triphosphate freeze-dried powder injection and increasing the mass stability and the yield of products; and experimental results show that the impurity content of the cytidine disdoium triphosphate freeze-dried powder injection prepared through the preparation method provided by the invention is below 0.41%.

The invention discloses a thermo-sensitive CTP (cytidine triphosphate) version developing solution, which comprises the following components: deionized water, metol, anhydrous sodium sulphite, sodium metaborate, potassium thiocyanate, potassium bromide, phenidone and fluorinated alkyl. The invention also discloses a preparation method of the thermo-sensitive CTP version developing solution, which comprises the following steps: firstly, adding the anhydrous sodium sulphite into the deionized water to stir for the first time to prepare a mixing solution I; then, adding the metol into the mixing solution I to stir for the second time to prepare a mixing solution II; subsequently adding the sodium metaborate, the phenidone and the potassium bromide into the mixing solution II to stir for the third time to prepare a mixing solution III; then, adding the potassium thiocyanate into the mixing solution III to stir for the fourth time to prepare a mixing solution IV; and finally, adding the fluorinated alkyl into the mixing solution IV to stir for the fifth time to obtain the thermo-sensitive CTP version developing solution. The developing solution disclosed by the invention has the advantages of wide allowable operating temperature range, good density stability of an image-text part, great tolerance level and the like and does not damage an aluminum sheet base.

The invention discloses a detection kit based on an aptamer. The detection kit comprises stem-loop structure nucleic acid H1, DNA (deoxyribonucleic acid) 1, DNA2 and DNA3, the stem-loop structure nucleic acid comprises the aptamer divided into two sections, the aptamer serves as a molecular recognition element, specific binding of molecules to be detected is achieved, catalytic activity of DNA enzymes is activated, substrate chains are circularly cut, high fluorescent detection signals are generated, and high-sensitivity detection is achieved. Detection limit of the detection kit for ATP (adenosine triphosphate) is 0.2 nanometer, detected linear range is wide and is 1 nanometer to 10 micrometers, a detection system has excellent specificity, common analogues comprising CTP (cytidine triphosphate), GTP (guanosine triphosphate) and UTP (uridine triphosphate) do not interfere detection results, separation and purification processes are omitted in the detecting process, detection can be achieved by simple blending, the detection kit has the advantages of simplicity in operation, low cost, quick response and the like, and the detection kit can be used for rapidly detecting and analyzingthe content of the ATP in environments or food samples.

The invention discloses a photosensitive composition adopting a composite dissolution-resistant agent/dissolution inhibitor, which comprises the dissolution-resistant agent/dissolution inhibitor, alkali soluble linear phenolic resin, an infrared absorbing dye, a background dye and a solvent, and the dissolution-resistant agent/dissolution inhibitor comprises a sulfonyl hydrazone compound and an ammonia amide salt. Since the chemical reaction type dissolution-resistant agent/dissolution inhibitor formed via compounding of the sulfonyl hydrazone compound and the ammonia amide salt is adopted, and the pH value of the prepared photosensitive composition, coating solution, for the thermosensitive CTP (cytidine triphosphate) plate changes little along with the time, the service life of the photosensitive composition, coating solution, is prolonged to be 7 days and even more than two weeks from 3-4 days when only the sulfonyl hydrazone compound is adopted, and the pH value of the photosensitive composition is still maintained higher than the initial pH value of the photosensitive composition, coating solution, prepared with the original proportion. The thermal sensitivity, resolution line width and developing tolerance of a thermosensitive layer obtained via coating and the storage stability of the plate are superior to or no interior to the effects when only the sulfonyl hydrazone compound is adopted.

The invention provides a recombinant microorganism for producing uridine and a method for producing uridine by using the recombinant microorganism. Wherein the uridine is degraded and knocked out by using genes, and the genes encode ribonucleoside hydrolase, uridine phosphorylase, nucleoside phosphorylase, cytidine/uridine kinase and nucleoside transporter protein. Meanwhile, overexpression is carried out on key enzymes in a uridine biosynthetic pathway, including cytidine triphosphate pyrophosphorylase for degrading cytidine triphosphate to cytidine monophosphate and uridine monophosphate phosphorylase for catalyzing uridine monophosphate to uridine. In addition, a pyrimidine nucleoside pathway is subjected to genetic engineering modification, and feedback inhibition of a synthetic pathway is relieved. The recombinant strain can reach the uridine yield of 20 g/L or above in a 5-liter fermentation tank through a biological fermentation method, industrial mass production can be achieved, meanwhile, the uridine production cost is low, pollution is reduced, the method is green and environmentally friendly, and the method has high application and popularization value.