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High-energy substance for preventing and treating neurodegenerative disease of old people and medical application of substance

A neurodegenerative, high-energy technology, applied in the direction of nervous system diseases, neuromuscular system diseases, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2014-01-22
陈铭
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report on the use of high-energy compounds for the treatment of neurodegenerative diseases

Method used

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  • High-energy substance for preventing and treating neurodegenerative disease of old people and medical application of substance
  • High-energy substance for preventing and treating neurodegenerative disease of old people and medical application of substance
  • High-energy substance for preventing and treating neurodegenerative disease of old people and medical application of substance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Example 1 tablet

[0107]

[0108] Excipients (corn starch 150g, croscarmellose 40g, microcrystalline cellulose 50g)

[0109] Make 1000 tablets, each 0.5g

Embodiment 2

[0110] Example 2 tablet

[0111]

[0112] Excipients (corn starch 100g, mannitol 75g, magnesium stearate 5g, sodium alginate 25g)

[0113] Make 1000 tablets, each 0.5g

Embodiment 3

[0114] Embodiment 3 injection powder

[0115] Phosphocreatine 50g, Acetyl Coenzyme A37.5g

[0116] Excipients (sorbitol 10g, polyethylene glycol 10g).

[0117]1000 bottles were prepared, each containing 50mg of creatine phosphate and 37.5mg of acetyl-CoA

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PUM

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Abstract

The invention relates to a high-energy substance for preventing and treating a neurodegenerative disease of old people. The high-energy substance comprises one or more of compounds and derivatives of the compounds of phosphoenolpyruvic acid, creatine phosphoric acid, acetyl coenzyme A, adenosine triphosphoric acid, L-carnitine, s-adenosylmethionine, guanosine triphosphate, cytidine triphosphate, pyrophosphoric acid, 1,3-diphosphoglycerate and succinyl coenzyme A. The high-energy substance has the benefits as follows: the high-energy substance is used for treating the neurodegenerative disease of the old people, particularly the aged population, so as to delay and prevent dementia; and the high-energy substance is proved to be a novel medicine which is reasonable, safe and economical and used for treating the neurodegenerative disease, particularly senile dementia.

Description

technical field [0001] The invention belongs to the field of drug application for senile neurodegenerative diseases, in particular to a treatment of senile neurodegenerative diseases with high-energy substances. Background technique [0002] Neurodegenerative disease is a general term for a group of diseases caused by chronic progressive degeneration of central nervous tissue. The common pathology is degeneration and loss of neurons in the brain or (and) spinal cord. In the elderly population, mainly include Alzheimer's disease (Alzheimer's disease, AD) (Alzheimer's disease or senile dementia), cerebellar atrophy, multiple sclerosis, Parkinson's disease, primary lateral sclerosis, spinal cord muscular atrophy etc. [0003] There are few marketed drugs for senile neurodegenerative diseases, mainly including dopamine-mimetic drugs and cholinergic receptor blocking drugs for the treatment of Parkinson's disease, such as levodopa, carbidopa, seligiline, and enzymatic drugs. Ta...

Claims

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Application Information

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IPC IPC(8): A61K31/661A61K31/664A61K31/7076A61K31/205A61K31/708A61K31/7068A61K33/42A61P25/28A61P21/00A61P19/10A61P9/10A61P25/16
Inventor 陈铭
Owner 陈铭