Application of cytidine as metabolic marker

Abstract

The invention belongs to the technical field of metabolic markers, and relates to application of cytidine serving as a metabolic marker for predicting death caused by acute and severe radioactive intestinal injuries. With the application of the cytidine serving as the metabolic marker for predicting death caused by acute and severe radioactive intestinal injuries of the invention, death caused byacute and severe radioactive intestinal injuries can be better predicted.

Description

technical field [0001] The invention belongs to the technical field of metabolic markers, and relates to the use of cytidine as a metabolic marker for predicting death caused by acute and severe radiation-induced intestinal injury. Background technique [0002] Radiation sickness can be divided into bone marrow type radiation sickness, intestinal type radiation sickness, and brain type radiation sickness according to the difference in exposure dose and damaged parts. At present, there is no effective treatment for intestinal type and brain type radiation etiology due to the high dose, and there is no long-term survival case. When a nuclear accident or nuclear war occurs, since the exposure dose of the on-site personnel is unknown, it is necessary to evaluate the patient's condition in time to determine the type of radiation sickness, so as to take corresponding treatment measures, which will buy time for the patient's rescue. [0003] At present, urine and blood are mostly ...

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Problems solved by technology

[0003] At present, urine and blood are mostly used as assessment samples for radiation damage (see: [1] Johnson CH, Patterson AD, Krausz KW, Kalinich JF, Tyburski JB, Kang DW, Luecke H, Gonzalez FJ, Blakely WF, Idle JR. Radiation metabolomics.5.Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by massspectrometry-based metabolomics.Radiat Res.2012 Oct;178(4):328-40.Epub 2012Sep 6.[2]Pannkuk EL,Laiakis EC,Authier S , Wong K, Fornace AJ Jr. Gas Chromatography / Mass Spectrometry Metabolomics of Urine and Serum from Nonhuman Primates Exposed to Ionizing Radiation: Impacts on the Tricarboxylic Acid Cycle and Protein Metabolism. J Proteome Res. 2017 May 5; 16(5): 2091-2100. doi:10.1021 / acs.jproteome.7b00064.Epub 2017 Apr 4.[3]Sharma M,MoulderJE.The urine proteome as a radiation biodosimeter.Adv Exp Med Biol.2013;990:87-100.doi:10.1007 / 978- 94-007-5896-4_5.), but there are few reports on the non-invasive evaluation of organ (intestine) specialized radiation injury, and most of the literature uses citrulline as a marker of intestinal radiation injury (see: [4] Crenn P , MessingB, Cynober L. Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction. Clin Nutr. 2008 Jun; 27(3):328-39.doi:10 .1016 / j.clnu.2008.02.005.Epub 2008 Apr 28.[5]Bujold K, Hauer-Jensen M, Donini O, Rumage A, Hartman D, Hendrickson HP, Stamatopoulos J, Naraghi H, Pouliot M, Ascah A, Sebastian M, Pugsley MK, Wong K, Authier S. Citrulline as a Biomarker for Gastrointestinal-Acute Radiation Syndrome: Species Differences and Experimental Condition Effects. Radiat Res. 2016 Jul; 186(1):71-8. doi:10.1667 / RR14305.1 .Epub 2016 Jun 28.[6]Jones JW,Bennett A,Carter CL,Tudor G,Hankey KG,Farese AM,Booth C,MacVittie TJ,Kane MA.Citrulline as a Biomarker in the Non-human Primate Total-and Partial -body Irradiation Models:Correlation of Circulating Citrulline to Acute and Prolonged Gastrointestinal Injury.HealthPhys.2015 Nov;109(5):440-51.doi:10.1097 / HP.0000000000000347.)

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