Application of cytidine as metabolic marker

A technology of cytidine nucleosides and metabolic markers, which is applied in the field of metabolic markers to predict death caused by acute and severe radiation-induced intestinal injury, can solve the problems of less non-invasive evaluation reports, and achieve the effect of predicting death and good death

Inactive Publication Date: 2021-03-23
SUZHOU UNIV
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  • Abstract
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Problems solved by technology

[0003] At present, urine and blood are mostly used as assessment samples for radiation damage (see: [1] Johnson CH, Patterson AD, Krausz KW, Kalinich JF, Tyburski JB, Kang DW, Luecke H, Gonzalez FJ, Blakely WF, Idle JR. Radiation metabolomics.5.Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by massspectrometry-based metabolomics.Radiat Res.2012 Oct;178(4):328-40.Epub 2012Sep 6.[2]Pannkuk EL,Laiakis EC,Authier S , Wong K, Fornace AJ Jr. Gas Chromatography/Mass Spectrometry Metabolomics of Urine and Serum from Nonhuman Primates Exposed to Ionizing Radiation: Impacts on the Tricarboxylic Acid Cycle and Protein Metabolism. J Proteome Res. 2017 May 5; 16(5): 2091-2100. doi:10.1021/acs.jproteome.7b00064.Epub 2017 Apr 4.[3]Sharma M,MoulderJE.The urine proteome as a radiation biodosimeter.Adv Exp Med Biol.2013;990:87-100.doi:10.1007/978- 94-007-5896-4_5.), but there are few reports on the non-invasive evaluation of organ (intestine) specialized radiation in

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  • Application of cytidine as metabolic marker
  • Application of cytidine as metabolic marker
  • Application of cytidine as metabolic marker

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Embodiment 1

[0011] Considering that the digestive systems of rodents and people are quite different, so the present invention uses Bama miniature pigs as an animal model (the structure of the digestive tract of pigs is similar to that of people), and three different dosages (13, 15, 18Gy) are used. The abdomen of animals was irradiated (these three doses can cause intestinal damage in animals), 13, 18Gy irradiation groups had three pigs in each dose, and the 15Gy irradiation group included 3 sows and 3 boars (in order to illustrate that female animals and male animals differences in radiosensitivity). Animal feces were collected every day before and after irradiation to measure P200 (200 metabolites, see Table 1) and neurotransmitters (13 kinds, see Table 2), and the survival rate was recorded every day. Pearson correlation analysis was performed between the measured values ​​of metabolites and neurotransmitters and the dose and survival rate, and the metabolites and neurotransmitters wit...

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Abstract

The invention belongs to the technical field of metabolic markers, and relates to application of cytidine serving as a metabolic marker for predicting death caused by acute and severe radioactive intestinal injuries. With the application of the cytidine serving as the metabolic marker for predicting death caused by acute and severe radioactive intestinal injuries of the invention, death caused byacute and severe radioactive intestinal injuries can be better predicted.

Description

technical field [0001] The invention belongs to the technical field of metabolic markers, and relates to the use of cytidine as a metabolic marker for predicting death caused by acute and severe radiation-induced intestinal injury. Background technique [0002] Radiation sickness can be divided into bone marrow type radiation sickness, intestinal type radiation sickness, and brain type radiation sickness according to the difference in exposure dose and damaged parts. At present, there is no effective treatment for intestinal type and brain type radiation etiology due to the high dose, and there is no long-term survival case. When a nuclear accident or nuclear war occurs, since the exposure dose of the on-site personnel is unknown, it is necessary to evaluate the patient's condition in time to determine the type of radiation sickness, so as to take corresponding treatment measures, which will buy time for the patient's rescue. [0003] At present, urine and blood are mostly ...

Claims

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Application Information

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IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/8813
Inventor 陈秋张学光崔凤梅
Owner SUZHOU UNIV
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