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Composite liposome for injection containing 12 vitamins and preparation method thereof

A technology of complex vitamins and liposomes, which is applied in liposome delivery, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as poor stability, singleness, and quality problems, and avoid decomposition, toxic and side effects Effect of reduction, improvement of medicinal effect

Inactive Publication Date: 2009-07-29
灵康药业集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the defects of poor stability and singleness and quality problems of most vitamins at present, the invention provides a liposome freeze-dried preparation of complex vitamins and a preparation method thereof, which solves the stability problem and improves its curative effect

Method used

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  • Composite liposome for injection containing 12 vitamins and preparation method thereof
  • Composite liposome for injection containing 12 vitamins and preparation method thereof
  • Composite liposome for injection containing 12 vitamins and preparation method thereof

Examples

Experimental program
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Effect test

example 1

[0033] Example 1 12 kinds of multivitamin liposome freeze-dried preparations

[0034] Formulation: 1000 vials Quantities of components required in unit dosage form:

[0035] Retinyl Palmitate 4.2 million units Niacinamide 50.6g

[0036] Thiamine Phosphate Tetrahydrate 6.38g Folic Acid 496mg

[0037] Riboflavin Sodium Phosphate 6.24g Dexpanthenol 17.77mg

[0038] Pyridoxine Hydrochloride 6.05g Soy Lecithin 150g

[0039] Cyanocobalamin 7.2mg Glycocholic Acid 170g

[0040] Cholecalciferol 264,000 units Citric acid 35g

[0041] Ascorbic acid 137.5g Potassium citrate 60g

[0042] rac Alpha-Tocopherol 11.22g Glycine 300g

[0043] D-Biotin 82.5mg

[0044] Preparation Process:

[0045] (1) Weigh soybean lecithin and glycocholic acid, dissolve them with an appropriate amount of chloroform, mix uniformly, and then remove the chloroform from the formed solution under reduced pressure to prepare a lipid film;

[0046] (2) Prepare a buffer solution of citric acid and potassium cit...

example 2

[0050] Example 2 12 kinds of multivitamin liposome freeze-dried preparations

[0051] Formulation: 1000 vials Quantities of components required in unit dosage form:

[0052] Retinyl Palmitate 2.8 million units Niacinamide 41.4g

[0053] Thiamine Phosphate Tetrahydrate 5.22g Folic Acid 332mg

[0054] Riboflavin Sodium Phosphate 5.10g Dexpanthenol 14.54mg

[0055] Pyridoxine Hydrochloride 4.95g Soy Lecithin 100g

[0056] Cyanocobalamin 4.8mg Glycocholic Acid 110g

[0057] Cholecalciferol 176,000 units Citric acid 7.5g

[0058] Ascorbic Acid 112.5g Potassium Citrate 14g

[0059] rac Alpha-Tocopherol 9.18g Glycine 200g

[0060] D-Biotin 55.2mg

[0061] Preparation Process:

[0062] Adopt the production method as embodiment 1 to make the product of embodiment 2.

example 3

[0063] Example 3 12 kinds of multivitamin liposome freeze-dried preparations

[0064] Formulation: 1000 vials Quantities of components required in unit dosage form:

[0065] Retinyl Palmitate 3.5 million units Niacinamide 46.0g

[0066] Thiamine Phosphate Tetrahydrate 5.80g Folic Acid 414mg

[0067] Riboflavin Sodium Phosphate 5.67g Dexpanthenol 16.15mg

[0068] Pyridoxine Hydrochloride 5.50g Soy Lecithin 112.5g

[0069] Cyanocobalamin 6.0mg Glycocholic Acid 140g

[0070] Cholecalciferol 220,000 units Citric acid 30.8g

[0071] Ascorbic acid 125.0g Potassium citrate 41.6g

[0072] rac Alpha-Tocopherol 10.20g Glycine 250g

[0073] D-Biotin 69.0mg

[0074] Preparation Process

[0075] Adopt the production method as embodiment 1 to make the product of embodiment 3.

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Abstract

The invention relates to a liposome lyophilized preparation prepared from twelve compound vitamins. The lyophilized preparation is characterized in that the lyophilized preparation is prepared from a liposome which consists of soybean lecithin and glycocholic acid and is encapsulated with twelve vitamins of retinyl palmitate, cocarboxylase tetrahydrate, riboflavin sodium phosphate, pyridoxine hydrochloride, cyanocobalamin, cholecalciferol, ascorbic acid, racemization-alpha tocopherol, D-biotin, niacinamide, folacin and dexpanthenol.

Description

technical field [0001] The invention relates to 12 kinds of complex vitamin liposome freeze-dried preparations and a preparation method thereof. Background technique [0002] Vitamins, also known as vitamins, are a class of organic substances necessary to maintain human life activities, and are also important active substances to maintain human health. The content of vitamins in the body is very small, but they play an important role in the growth, metabolism and development of the human body. When they are deficient, they can lead to metabolic disorders and various diseases. [0003] At present, most of the domestically produced vitamin preparations are administered with individual ingredients, and there are fewer multivitamin preparations, and most of the dosage forms are oral preparations of tablets and capsules, which greatly limits the absorption of different vitamins by the human body, causing troubles in the use of medicines, and may also affect the safety of medicati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/675A61P3/02A61K31/164A61K31/4415A61K31/23A61K31/593A61K31/519A61K31/375A61K31/355A61K31/714A61K31/4188A61K31/455
Inventor 陶灵刚
Owner 灵康药业集团股份有限公司
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