Medicine composition containing pravastatin sodium fenofibrate liposome and preparation method of medicine composition

Abstract

The invention relates to a medicine composition containing a pravastatin sodium fenofibrate liposome and a preparation method of the medicine composition. The medicine composition comprises a pravastatin sodium fenofibrate liposome and at least one pharmaceutically acceptable vector, wherein the pravastatin sodium fenofibrate liposome comprises pravastatin sodium, fenofibrate, phospholipid and cholesterol. The medicine composition prepared by the pravastatin sodium fenofibrate liposome not only satisfies the requirements of Chinese Pharmacopoeia and has the advantages of faster dissolution, faster medicine efficacy, high bioavailability, good stability as well as worth of being widely promoted and applied when being compared with the common pravastatin sodium fenofibrate medicine composition.

Description

technical field [0001] The invention relates to a pharmaceutical composition comprising pravastatin sodium fenofibrate liposome and a preparation method thereof, wherein the pharmaceutical composition is composed of pravastatin sodium fenofibrate liposome and at least one pharmaceutical The above-mentioned carrier is acceptable, wherein the pravastatin sodium fenofibrate liposome is composed of pravastatin sodium, fenofibrate, phospholipid and cholesterol, and belongs to the technical field of medicine. Background technique [0002] Cardiovascular disease has become the first cause of death in urban and rural populations in my country. Cardiovascular disease in China is characterized by a high incidence of stroke and a low incidence of coronary heart disease. However, the incidence and mortality of coronary heart disease have gradually increased in the past 20 years; In large cities with rapid economic development, such as Beijing, the monitoring results show that the inciden...

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Problems solved by technology

[0026] The problem to be solved by the present invention is to overcome the defects of the prior art and provide a pharmaceutical composition comprising pravastatin sodium fenofibrate liposomes and a preparation method thereof, in order to solve the stability of pravastatin sodium in gastric acid problem, low bioavailability problem, and easy to form lactone problem when heated, and also solves the problem of low bioavailability of fenofibrate, providing a stable composition with low level of impurities and / or degradation products, said Impurities and / or degradation may occur during the preparation and / or subsequent storage of the composition

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