The invention discloses a cynanchum otophyllum dispersible tablet and a preparation method thereof, relating to medicines. The cynanchum otophyllum dispersible tablet is made of the following raw materials by weight portions: 50-200 portions of an extract of cynanchum otophyllum total glucoside, 20-100 portions of an disintegrating agent, 1-10 portions of a lubricant and 1-20 portions of a surfactant, wherein, the disintegrating agent is CMS-Na, CCNa, PVPP, L-HPC and dry starch, the lubricant is magnesium stearate or talcum powder or superfine silica gel powder, the surfactant is SDS, sodium hexadecyl sulfate and sodium stearyl sulfate. The preparation method consists of the following steps: 20-200 portions of total glucoside of the cynanchum otophyllum by weight is taken out and sieved with a 100-mesh sieve; 20-100 portions of the disintegrating agent by weight and 1-10 portions of the lubricant by weight are taken out and respectively sieved with the 100-mesh sieve; 1-20 portions of the surfactant by weight is taken out and sieved with a 80-mesh sieve; then the sieved extract, the sieved disintegrating agent, the sieved lubricant and the sieved surfactant are ground and evenly mixed, and then the mixture is sieved with the 80-mesh sieve, and direct compression and sieving are carried out on the sieved mixture to obtain the dispersible tablet. The dispersible tablet has high dissolution and high bioavailability, can fully exert the drug action of the cynanchum otophyllum, and the preparation method is simple and feasible while suitable for industrialized production.