Dispersible tablet containing cefixime liposome and preparation method thereof

A cefixime and liposome technology, applied in the field of medicine, can solve the problems of poor solubility, stability, and bioavailability, and achieve the effects of improving bioavailability, improving bioavailability, and rapidly exerting drug effects

Inactive Publication Date: 2011-02-09
王丽燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Chinese patents CN101606913A and CN101401810A disclose cefixime dispersible tablets and their preparation methods. The dispersible tablets are all made from cefixime raw materials without any modification. The solubility, stability and biological Utilization is poor

Method used

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  • Dispersible tablet containing cefixime liposome and preparation method thereof
  • Dispersible tablet containing cefixime liposome and preparation method thereof
  • Dispersible tablet containing cefixime liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Embodiment 1: the preparation of cefixime liposome

[0074] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

Cefixime

50.00

100.00

200.00

Hydrogenated Soy Lecithin

200.00

400.00

800.00

Hydrogenated egg yolk lecithin

200.00

400.00

800.00

cholesterol

400.00

800.00

1600.00

Polysorbate 80

74.00

148.00

296.00

total

924.00

1848.00

3696.00

[0075] Preparation:

[0076] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and polysorbate 80 in an appropriate amount of dehydrated alcohol according to the prescription amount, and mix uniformly to obtain solution I; 30 times;

[0077] (B) take by weighing the cefixime of recipe quantity, add the phosphate buffer saline solution that an appropriate pH value is 7.9 and make it dissolve completely, obtain cefixime solution;

[0078...

Embodiment 2

[0084] Embodiment 2: the preparation of cefixime liposome

[0085] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

Cefixime

50.00

50.00

100.00

Hydrogenated Soy Lecithin

162.50

325.00

650.00

Hydrogenated egg yolk lecithin

162.50

325.00

650.00

cholesterol

325.00

650.00

1300.00

Polysorbate 80

60.00

120.00

240.00

total

760.00

1520.00

3040.00

[0086] Preparation:

[0087] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and polysorbate 80 in an appropriate amount of dehydrated alcohol according to the prescription amount, and mix uniformly to obtain solution I; 25 times;

[0088] (B) take by weighing the cefixime of recipe quantity, add the phosphate buffer saline solution that proper pH value is 7.6 and make it dissolve completely, obtain cefixime solution;

[0089] (C) take ...

Embodiment 3

[0095] Embodiment 3: the preparation of cefixime liposome

[0096] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

Cefixime

50.00

100.00

200.00

Hydrogenated Soy Lecithin

140.00

280.00

560.00

Hydrogenated egg yolk lecithin

140.00

280.00

560.00

cholesterol

280.00

560.00

1120.00

Polysorbate 80

50.00

100.00

200.00

total

660.00

1320.00

2640.00

[0097] Preparation:

[0098] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and polysorbate 80 in an appropriate amount of dehydrated alcohol according to the prescription amount, and mix uniformly to obtain solution I; 35 times;

[0099] (B) take by weighing the cefixime of recipe quantity, add the phosphate buffer saline solution that an appropriate pH value is 7.0 and make it dissolve completely, obtain cefixime solution;

[0100...

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Abstract

The invention relates to a cefixime liposome, a preparation method thereof and a dispersible tablet containing the cefixime liposome. The dispersible tablet comprises the cefixime liposome and a pharmaceutically acceptable carrier, wherein the cefixime liposome comprises the following components in parts by weight: 1 part of cefixime, 1.25-5 parts of hydrogenated soybean lecithin, 1.25-5 parts of hydrogenated egg yolk lecithin, 1.25-10 parts of cholesterol and 0.2-3.5 parts of polysorbate 80. The dispersible tablet not only conforms to the requirements of a Chinese pharmacopoeia, but also has the advantages of more stable storage under normal temperature and remarkable improvement of bioavailability compared with the ordinary cefixime medicament composition, and can take effect more rapidly.

Description

technical field [0001] The invention relates to a cefixime liposome, a preparation method thereof and a dispersible tablet containing it. The cefixime dispersible tablet is more stable in storage at room temperature and more effective in exerting drug effects than ordinary cefixime pharmaceutical compositions. The invention has the advantages of rapidity and significantly improved bioavailability, and belongs to the technical field of medicine. Background technique [0002] Acute pelvic inflammatory disease refers to the acute inflammation of female pelvic reproductive organs and its surrounding connective tissue and pelvic peritoneum, including metritis, salpingo-oophoritis, pelvic connective tissue inflammation and pelvic peritonitis, which can occur in one or several places at the same time. One of the common diseases. The development of acute pelvic inflammatory disease can cause diffuse peritonitis, sepsis, septic shock, and severe cases can be life-threatening. Lower...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P15/00A61K9/20A61K31/546A61P31/04A61K47/28
Inventor 王丽燕
Owner 王丽燕
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