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Tablet containing cefprozi liposome and preparation method thereof

A technology of propylene tablets and cefprozil, which is applied in the field of medicine, can solve the problems of poor solubility, stability and bioavailability of preparations, and low encapsulation efficiency of cefprozil submicroemulsion, so as to avoid peak and valley phenomena and improve biological efficiency. Utilization, effect of significant improvement

Inactive Publication Date: 2011-01-26
王丽燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Chinese patent CN101700232A discloses a cefprozil submicron emulsion solid preparation and its new application, which is characterized in that it is composed of cefprozil, egg yolk lecithin, poloxamer 188 and sodium deoxycholate, and the prepared cefprozil sub Microemulsion encapsulation efficiency is low
[0014] Chinese patent CN101032489A discloses a kind of cefprozil dispersible tablet and preparation method thereof, described dispersible tablet is to adopt simple cefprozil crude drug without any modification to make, and the solubility, stability and bioavailability of the obtained preparation are average. poor

Method used

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  • Tablet containing cefprozi liposome and preparation method thereof
  • Tablet containing cefprozi liposome and preparation method thereof
  • Tablet containing cefprozi liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1: the preparation of cefprozil liposome

[0073] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

cefprozil

62.50

125.00

250.00

Hydrogenated Soy Lecithin

156.25

312.50

625.00

Hydrogenated egg yolk lecithin

156.25

312.50

625.00

cholesterol

312.50

625.00

1250.00

total

687.50

1375.00

2750.00

[0074] Preparation:

[0075] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin and cholesterol in an appropriate amount of absolute ethanol according to the prescription amount, mix well, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, and dry under reduced pressure in a vacuum . The amount of dehydrated alcohol used is 30 times of the amount of cefprozil.

[0076] (B) Weigh the prescribed amount of cefprozil, add an appropriate amoun...

Embodiment 2

[0081] Embodiment 2: the preparation of cefprozil liposome

[0082] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

[0083] cefprozil

62.50

125.00

250.00

Hydrogenated Soy Lecithin

181.25

362.50

725.00

Hydrogenated egg yolk lecithin

181.25

362.50

725.00

cholesterol

362.50

725.00

1450.00

total

787.50

1575.00

3150.00

[0084] Preparation:

[0085] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin and cholesterol in an appropriate amount of absolute ethanol according to the prescription amount, mix well, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, and dry under reduced pressure in a vacuum . The amount of dehydrated alcohol used is 30 times of the amount of cefprozil.

[0086] (B) Weigh the prescribed amount of cefprozil, and a...

Embodiment 3

[0091] Embodiment 3: the preparation of cefprozil liposome

[0092] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

cefprozil

62.50

125.00

250.00

Hydrogenated Soy Lecithin

312.50

625.00

1250.00

Hydrogenated egg yolk lecithin

312.50

625.00

1250.00

cholesterol

625.00

1250.00

2500.00

total

1312.50

2625.00

5250.00

[0093] Preparation:

[0094] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin and cholesterol in an appropriate amount of absolute ethanol according to the prescription amount, mix well, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, and dry under reduced pressure in a vacuum . The amount of dehydrated alcohol used is 30 times of the amount of cefprozil.

[0095] (B) Weigh the prescribed amount of cefprozil, and add an appropria...

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Abstract

The invention relates to a cefprozi liposome, a preparation method thereof and a tablet containing the cefprozi liposome. The cefprozi liposome comprises cefprozi, hydrogenated soybean phosphatidylcholine, hydrogenated egg yolk lecithin and cholesterol, wherein the weight ratio of the cefprozi, the hydrogenated soybean phosphatidylcholine, the hydrogenated egg yolk lecithin and the cholesterol is 1:1.25-5:1.25-5:2.5-10. The cefprozi tablet meets the requirements of Chinese Pharmacopoeia and also has the advantages of higher dissolution rate, faster effect and greatly enhanced bioavailability compared with the ordinary cefprozi drug composite.

Description

technical field [0001] The invention relates to a cefprozil liposome, a preparation method thereof and a tablet containing it. The cefprozil tablet has a higher dissolution rate than a common cefprozil pharmaceutical composition, a faster drug effect, and a higher bioavailability. The advantages of significant improvement belong to the technical field of medicine. Background technique [0002] Acute cholecystitis is a common disease. In my country, according to literature reports, it ranks second among acute abdominal surgical diseases, second only to acute appendicitis, and is more common than acute intestinal obstruction and ulcer perforation. The disease is more common in middle-aged people aged 35 to 40, and women are more likely to suffer from it than men, especially women who are obese and have multiple pregnancies. The onset of acute cholecystitis is due to obstruction of the cystic duct by stones, resulting in the retention of bile in the gallbladder, followed by b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/545A61K47/28A61K47/32A61K9/20A61P1/16A61P31/04
Inventor 王丽燕
Owner 王丽燕
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