10 results about "Cefprozil" patented technology

The invention belongs to the technical field of medicine preparation, and discloses a preparation method of a novel cefprozil dry suspension and the cefprozil dry suspension, the cefprozil dry suspension comprises cefprozil and auxiliary materials, the preparation method comprises the following steps: (1) mixing the auxiliary materials: mixing at least part of the auxiliary materials to obtain premixed powder for later use; and (2) preparation of a dry suspension: uniformly mixing the premixed powder, the remaining auxiliary materials and cefprozil with the particle size D90 of 40-200 [mu] m to obtain the dry suspension, wherein if all the auxiliary materials in the step (1) are mixed to prepare the premixed powder, the auxiliary materials in the step (2) do not contain the residual auxiliary materials. According to the invention, the raw material medicine cefprozil is not crushed or screened and is directly mixed with the premixed powder obtained by mixing various auxiliary materials to prepare the dry suspension, the process steps are simple, the content of related substances in the obtained dry suspension can be effectively controlled, and the medicine quality is ensured.

The invention relates to a method for determining related substances of a compound preparation cefprozil and probenecid tablet, which is characterized in that the related substances are detected by high performance liquid chromatography, the related substances are impurities in the compound preparation cefprozil and probenecid, and the content of the impurity cefadroxil, other single impurities and total impurities is determined; wherein the mobile phase A is a 0.23% ammonium dihydrogen phosphate solution, and the mobile phase B is HPLC (High Performance Liquid Chromatography) grade methanol; a sample is diluted by a diluent and then is injected, the diluent is a mixed solution of a 0.23% ammonium dihydrogen phosphate solution and HPLC-grade methanol, the sample injection amount of the sample is 5 [mu] L, the concentration of cefprozil is 1.5 mg / mL, and the concentration of probenecid is 2.25 mg / ml; according to the present invention, the related substances in the cefprozil and the probenecid can be simultaneously detected, the detection cost is reduced, the method has advantages of strong specificity, high sensitivity, good reproducibility and good accuracy, has certain feasibility and practicality, is easy to popularize and apply, and can provide the research reference for the quality control and evaluation of the product.

The invention belongs to the field of biological material preparation, and particularly relates to degradable drug-loading hydrogel and a preparation method thereof.Acrylate groups are introduced into 6s-PLA, 6s-PLA-HA is synthesized, a hydrogel material is synthesized through a photopolymerization method, then cefprozil serves as a model drug, and drug loading is conducted on the hydrogel through the supercritical impregnation technology. The composite material is self-prepared six-arm star-shaped polylactic acid (6s-PLA), the 6s-PLA is terminated by using acryloyl chloride to synthesize 6s-PLA-HA, PLA-PEG hydrogel is prepared by using a photopolymerization method, and a hydrogel material loaded with cefprozil is prepared by using a supercritical carbon dioxide impregnation technology. The material has the advantages of being excellent in mechanical property, non-toxic, good in biological safety, non-irritant, easy to process and form, degradable, anti-inflammatory and the like, and is expected to be widely applied to the field of biomedical materials.

The invention belongs to the technical field of drug preparation, and discloses a preparation method of a cefprozil dry suspension and a cefprozil dry suspension. The cefprozil dry suspension comprises cefprozil and excipients, and the preparation method comprises the following steps: (1) excipient mixing: mixing at least part of the excipients to obtain a premixed powder for standby use; (2) dry suspension preparation: uniformly mixing the premixed powder, the remaining excipients, and cefprozil with a particle size D90 of 40 to 200 μm; wherein, if all the excipients are mixed to form a premixed powder in step (1), the remaining excipients are not included in step (2). In the present invention, the raw material drug cefprozil is not crushed or sieved, but is directly mixed with the premixed powder obtained by mixing various excipients to prepare a dry suspension, the process steps are simple, and the content of related substances in the obtained dry suspension can be effectively controlled, thereby ensuring the quality of the drug.

The sterile smashing device comprises a bottom frame, a first connecting shell is connected to the surface of the bottom frame through bolts, connecting plates are welded to the two sides of the first connecting shell, a cover plate is detachably connected to one end of the first connecting shell, and a tempered glass ring is fixedly connected to the surface of the cover plate; a screw is in threaded connection with the interior of the connecting plate, the screw and the cover plate are detachably connected, an anti-blocking assembly is jointly arranged on the surface of the first connecting shell and the surface of the cover plate, and a second motor is fixedly connected to one side of the anti-blocking assembly. When the cover plate needs to be taken down from the surface of the first connecting shell, the screw in the connecting plate can be screwed outwards, so that the cover plate can be taken down, and when the tempered glass ring is used for installing the cover plate, the positioning hole in the surface of the cover plate and the positioning structure in the first connecting shell can be conveniently observed to be positioned together.

The utility model discloses a kind of packing equipment for cefprozil dry suspension, belong to the technical field of drug packaging, it includes lathe.The packing equipment for cefprozil dry suspension, when suspending agent is packed, because rack and blanking tube bottom end are attached, make that suspending agent is accumulated in blanking tube, operator starts first motor and drives worm rotation, worm drives worm wheel and first gear rotation, first gear drives first sector gear rotation, first sector gear drives rack movement, first gear drives second gear and second sector gear rotation, when second sector gear and rack contact, first sector gear just separates from rack, second sector gear pushes rack reverse movement, to make rack reciprocating movement, and then the suspending agent in blanking tube is quantitatively discharged, prevent the discharging quality of suspending agent to be different, cause the amount of suspending agent in each packaging box to have error, improve the precision and functionality of the equipment.

The invention relates to a preparation method of a cefprozil EP impurity E. The preparation method comprises the following step: in the presence of a condensing agent, carrying out intermolecular dimerization on a compound shown as a formula I to prepare a compound shown as a formula II. And adding a carboxyl protecting group on the compound in the formula III to prepare a compound in a formula IV. In the presence of a condensing agent, the compound shown in the formula II and the compound shown in the formula IV are subjected to a condensation reaction to prepare the compound shown in the formula V. Under the acidic condition, the compound shown in the formula V is subjected to deprotection, and the cefprozil EP impurity E (a compound shown in a formula VI) is prepared. The preparation method provided by the invention has the advantages of short route, simple operation, convenient purification and high product purity, and provides a basis for quality research of cefprozil.

1. The name of this design product: Packaging box (Cefprozil for Oral Suspension 1.25g / bottle / box). 2. The use of this design product: For drug packaging. 3. The design key points of this design product: Lie in the combination of pattern and color. 4. The picture or photo that best shows the design key points: The front view. 5. The design of the appearance for which protection is requested includes color.

The invention discloses a synthetic method of a cefprozil intermediate 7-APRA, and belongs to the technical field of chemical raw material medicines. The method is characterized in that a reactant 7-amino-3-vinyl-3-cephem-4-carboxylic acid is prepared into an intermediate I under the action of a reaction catalyst copper trifluoromethanesulfonate, a reaction assistant tripotassium phosphate and a base catalyst N-methylaniline, and 7-APRA is prepared through an elimination reaction. The method can effectively solve the problems of many synthesis steps, low product yield, high catalyst toxicity, high isomer content, need of chromatographic separation technology for separation and the like, and the level of the prepared cefprozil isomer (E type) meets the national pharmacopoeia standard.

The invention discloses a cefprozil crystal form and a preparation method, and belongs to the technical field of chemical bulk drugs, an X-ray powder diffraction pattern (XRPD) of the crystal form X comprises the following characteristic peaks: 8.8, 12.2, 13.3, 18.2, 18.8, 20.8, 21.2, 22.4 and 23.0, and the solubility of the new crystal form X of cefprozil is slightly soluble. N-heptane is used for secondary crystallization and crystal growing, a crystal form X cefprozil is obtained, and the solubility of the crystal form X cefprozil is slightly soluble; the crystal form has the advantages of perfect crystal form structure, high purity, good crystal form and good crystal form structure stability, and can meet the requirement of 80% in-vitro dissolution rate in pharmacopeia without being prepared into tablets through micronization treatment.