4 results about "Cefprozil" patented technology

The invention belongs to the field of biological material preparation, and particularly relates to degradable drug-loading hydrogel and a preparation method thereof.Acrylate groups are introduced into 6s-PLA, 6s-PLA-HA is synthesized, a hydrogel material is synthesized through a photopolymerization method, then cefprozil serves as a model drug, and drug loading is conducted on the hydrogel through the supercritical impregnation technology. The composite material is self-prepared six-arm star-shaped polylactic acid (6s-PLA), the 6s-PLA is terminated by using acryloyl chloride to synthesize 6s-PLA-HA, PLA-PEG hydrogel is prepared by using a photopolymerization method, and a hydrogel material loaded with cefprozil is prepared by using a supercritical carbon dioxide impregnation technology. The material has the advantages of being excellent in mechanical property, non-toxic, good in biological safety, non-irritant, easy to process and form, degradable, anti-inflammatory and the like, and is expected to be widely applied to the field of biomedical materials.

The sterile smashing device comprises a bottom frame, a first connecting shell is connected to the surface of the bottom frame through bolts, connecting plates are welded to the two sides of the first connecting shell, a cover plate is detachably connected to one end of the first connecting shell, and a tempered glass ring is fixedly connected to the surface of the cover plate; a screw is in threaded connection with the interior of the connecting plate, the screw and the cover plate are detachably connected, an anti-blocking assembly is jointly arranged on the surface of the first connecting shell and the surface of the cover plate, and a second motor is fixedly connected to one side of the anti-blocking assembly. When the cover plate needs to be taken down from the surface of the first connecting shell, the screw in the connecting plate can be screwed outwards, so that the cover plate can be taken down, and when the tempered glass ring is used for installing the cover plate, the positioning hole in the surface of the cover plate and the positioning structure in the first connecting shell can be conveniently observed to be positioned together.

The utility model discloses a kind of packing equipment for cefprozil dry suspension, belong to the technical field of drug packaging, it includes lathe.The packing equipment for cefprozil dry suspension, when suspending agent is packed, because rack and blanking tube bottom end are attached, make that suspending agent is accumulated in blanking tube, operator starts first motor and drives worm rotation, worm drives worm wheel and first gear rotation, first gear drives first sector gear rotation, first sector gear drives rack movement, first gear drives second gear and second sector gear rotation, when second sector gear and rack contact, first sector gear just separates from rack, second sector gear pushes rack reverse movement, to make rack reciprocating movement, and then the suspending agent in blanking tube is quantitatively discharged, prevent the discharging quality of suspending agent to be different, cause the amount of suspending agent in each packaging box to have error, improve the precision and functionality of the equipment.

The invention relates to a preparation method of a cefprozil EP impurity E. The preparation method comprises the following step: in the presence of a condensing agent, carrying out intermolecular dimerization on a compound shown as a formula I to prepare a compound shown as a formula II. And adding a carboxyl protecting group on the compound in the formula III to prepare a compound in a formula IV. In the presence of a condensing agent, the compound shown in the formula II and the compound shown in the formula IV are subjected to a condensation reaction to prepare the compound shown in the formula V. Under the acidic condition, the compound shown in the formula V is subjected to deprotection, and the cefprozil EP impurity E (a compound shown in a formula VI) is prepared. The preparation method provided by the invention has the advantages of short route, simple operation, convenient purification and high product purity, and provides a basis for quality research of cefprozil.