Capsule containing cefprozil liposome and preparation method thereof

A technology of cefprozil and acrylic ester, which is applied in the field of medicine, can solve the problems of poor solubility, stability and bioavailability of preparations, and low encapsulation efficiency of cefprozil submicroemulsion, so as to avoid peak and valley phenomena and improve bioavailability The effect of degree and full pharmacodynamic effect

Inactive Publication Date: 2011-01-26
王丽燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Chinese patent CN101700232A discloses a cefprozil submicron emulsion solid preparation and its new application, which is characterized in that it is composed of cefprozil, egg yolk lecithin, poloxamer 188 and sodium deoxycholate, and the prepared cefprozil sub Microemulsion encapsulation efficiency is low
[0014] Chinese patent CN101032489A discloses a kind of cefprozil dispersible tablet and preparation method thereof, described dispersible tablet is to adopt simple cefprozil crude drug without any modification to make, and the solubility, stability and bioavailability of the obtained preparation are average. poor

Method used

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  • Capsule containing cefprozil liposome and preparation method thereof
  • Capsule containing cefprozil liposome and preparation method thereof
  • Capsule containing cefprozil liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Embodiment 1: the preparation of cefprozil liposome

[0072] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

cefprozil

62.50

125.00

250.00

Hydrogenated egg yolk lecithin

156.25

312.50

625.00

Soy Lecithin

156.25

312.50

625.00

cholesterol

312.50

625.00

1250.00

Vitamin E

50.00

100.00

200.00

total

737.50

1475.00

2950.00

[0073] Preparation:

[0074] (A) Dissolve hydrogenated egg yolk lecithin, soybean lecithin, cholesterol and vitamin E in an appropriate amount of absolute ethanol according to the prescription amount, mix evenly, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, and vacuum reduce Press dry. The amount of dehydrated alcohol used is 30 times of the amount of cefprozil.

[0075] (B) Weigh the prescribed amount of cefprozil...

Embodiment 2

[0080] Embodiment 2: the preparation of cefprozil liposome

[0081] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

[0082] cefprozil

62.50

125.00

250.00

Hydrogenated egg yolk lecithin

175.00

350.00

700.00

Soy Lecithin

175.00

350.00

700.00

cholesterol

350.00

700.00

1400.00

Vitamin E

50.00

100.00

200.00

total

812.50

1625.00

3250.00

[0083] Preparation:

[0084] (A) Dissolve hydrogenated egg yolk lecithin, soybean lecithin, cholesterol and vitamin E in an appropriate amount of absolute ethanol according to the prescription amount, mix evenly, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, and vacuum reduce Press dry. The amount of dehydrated alcohol used is 30 times of the amount of cefprozil.

[0085] (B) Weigh the prescribed ...

Embodiment 3

[0090] Embodiment 3: the preparation of cefprozil liposome

[0091] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

cefprozil

62.50

125.00

250.00

Hydrogenated egg yolk lecithin

312.50

625.00

1250.00

Soy Lecithin

312.50

625.00

1250.00

cholesterol

625.00

1250.00

2500.00

Vitamin E

50.00

100.00

200.00

[0092] total

1362.50

2725.00

5450.00

[0093] Preparation:

[0094] (A) Dissolve hydrogenated egg yolk lecithin, soybean lecithin, cholesterol and vitamin E in an appropriate amount of absolute ethanol according to the prescription amount, mix evenly, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, and vacuum reduce Press dry. The amount of dehydrated alcohol used is 30 times of the amount of cefprozil.

[0095] (B) Weigh the prescri...

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Abstract

The invention relates to a cefprozil liposome and a preparation method thereof as well as a capsule containing the cefprozil liposome. The cefprozil liposome comprises cefprozil, hydrogenated yolk lecithin, soyabean lecithin, cholesterol and vitamin E, wherein the weight ratio of the cefprozil to the hydrogenated yolk lecithin to the soyabean lecithin to the cholesterol and to the vitamin E is 1:(1.25-5):(1.25-5):(2.5-10):(0.1-3). The cefprozil capsule not only meets the Chinese pharmacopoeia requirement but also has the advantages of higher dissolution rate, faster action of medicament effect and obvious improvement of bioavailability compared with those of a common cefprozil pharmaceutical composition.

Description

technical field [0001] The invention relates to a cefprozil liposome, a preparation method thereof and a capsule containing it. The cefprozil capsule has a higher dissolution rate than a common cefprozil pharmaceutical composition, a faster drug effect, and a higher bioavailability. The advantages of significant improvement belong to the technical field of medicine. Background technique [0002] Acute cholecystitis is a common disease. In my country, according to literature reports, it ranks second among acute abdominal surgical diseases, second only to acute appendicitis, and is more common than acute intestinal obstruction and ulcer perforation. The disease is more common in middle-aged people aged 35 to 40, and women are more likely to suffer from it than men, especially women who are obese and have multiple pregnancies. The onset of acute cholecystitis is due to obstruction of the cystic duct by stones, resulting in the retention of bile in the gallbladder, followed by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/545A61K47/28A61K9/48A61K47/32A61P1/16A61P31/04
Inventor 王丽燕
Owner 王丽燕
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