Dry suspension containing cefprozil liposome and preparation method thereof

A technology of cefprozil and dry suspension, applied in the field of medicine, can solve the problems of low encapsulation rate of cefprozil submicroemulsion, poor preparation solubility, stability and bioavailability, etc., so as to improve bioavailability, avoid Peak and valley phenomenon, better storage effect

Inactive Publication Date: 2011-01-26
王丽燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Chinese patent CN101700232A discloses a cefprozil submicron emulsion solid preparation and its new application, which is characterized in that it is composed of cefprozil, egg yolk lecithin, poloxamer 188 and sodium deoxycholate, and the prepared cefprozil sub Microemulsion encapsulation efficiency is low

Method used

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  • Dry suspension containing cefprozil liposome and preparation method thereof
  • Dry suspension containing cefprozil liposome and preparation method thereof
  • Dry suspension containing cefprozil liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Embodiment 1: the preparation of cefprozil liposome

[0071] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

cefprozil

62.50

125.00

250.00

Hydrogenated Soy Lecithin

156.25

312.50

625.00

Hydrogenated egg yolk lecithin

156.25

312.50

625.00

cholesterol

312.50

625.00

1250.00

Vitamin E

50.00

100.00

200.00

total

737.50

1475.00

2950.00

[0072] Preparation:

[0073] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and vitamin E in an appropriate amount of absolute ethanol according to the prescription amount, mix evenly, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, vacuum Dry under reduced pressure. The amount of dehydrated alcohol used is 30 times of the amount of cefprozil.

[0074] (B) Weigh th...

Embodiment 2

[0079] Embodiment 2: the preparation of cefprozil liposome

[0080] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

cefprozil

62.50

125.00

250.00

[0081] Hydrogenated Soy Lecithin

256.25

512.50

1025.00

Hydrogenated egg yolk lecithin

256.25

512.50

1025.00

cholesterol

512.50

1025.00

2050.00

Vitamin E

50.00

100.00

200.00

total

1137.50

2275.00

4550.00

[0082] Preparation:

[0083] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and vitamin E in an appropriate amount of absolute ethanol according to the prescription amount, mix evenly, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, vacuum Dry under reduced pressure. The amount of dehydrated alcohol used is 30 times of the amount of cefprozil....

Embodiment 3

[0089] Embodiment 3: the preparation of cefprozil liposome

[0090] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

cefprozil

62.50

125.00

250.00

Hydrogenated Soy Lecithin

312.50

625.00

1250.00

Hydrogenated egg yolk lecithin

312.50

625.00

1250.00

cholesterol

625.00

1250.00

2500.00

Vitamin E

50.00

100.00

200.00

total

1362.50

2725.00

5450.00

[0091] Preparation:

[0092] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and vitamin E in an appropriate amount of absolute ethanol according to the prescription amount, mix evenly, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, vacuum Dry under reduced pressure. The amount of dehydrated alcohol used is 30 times of the amount of cefprozil.

[0093] (B) Weig...

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PUM

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Abstract

The invention relates to a cefprozil liposome, a preparation method thereof and a dry suspension containing the cefprozil liposome. The cefprozil liposome comprises cefprozil, hydrogenated soya bean lecithin, hydrogenated yolk lecithin, cholesterol and vitamin E in the weight ratio of 1:(1.25-5):(1.25-5):(2.5-10):(0.1-3). The dry suspension containing the cefprozil liposome not only conforms to the requirements of Chinese pharmacopoeia, but also has the advantages of more stable storage at normal temperature, rapider effect taking and obviously increased bioavailability compared with common cefprozil medicine compositions.

Description

technical field [0001] The invention relates to a cefprozil liposome, a preparation method thereof and a dry suspension containing it. The cefprozil dry suspension is more stable than the common cefprozil pharmaceutical composition, the drug effect is exerted faster, and the biological The advantage of significantly improved utilization belongs to the technical field of medicine. Background technique [0002] Acute cholecystitis is a common disease. In my country, according to literature reports, it ranks second among acute abdominal surgical diseases, second only to acute appendicitis, and is more common than acute intestinal obstruction and ulcer perforation. The disease is more common in middle-aged people aged 35 to 40, and women are more likely to suffer from it than men, especially women who are obese and have multiple pregnancies. The onset of acute cholecystitis is due to obstruction of the cystic duct by stones, resulting in the retention of bile in the gallbladde...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/545A61K47/28A61K47/32A61K9/16A61P1/16A61P31/04
Inventor 王丽燕
Owner 王丽燕
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