Dry suspension containing cefprozil liposome and preparation method thereof
A technology of cefprozil and dry suspension, applied in the field of medicine, can solve the problems of low encapsulation rate of cefprozil submicroemulsion, poor preparation solubility, stability and bioavailability, etc., so as to improve bioavailability, avoid Peak and valley phenomenon, better storage effect
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- Publication Date
- 2011-01-26
- Estimated Expiration
- Not applicable · inactive patent
Smart Images
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Abstract
Description
technical field
[0001] The invention relates to a cefprozil liposome, a preparation method thereof and a dry suspension containing it. The cefprozil dry suspension is more stable than the common cefprozil pharmaceutical composition, the drug effect is exerted faster, and the biological The advantage of significantly improved utilization belongs to the technical field of medicine. Background technique
[0002] Acute cholecystitis is a common disease. In my country, according to literature reports, it ranks second among acute abdominal surgical diseases, second only to acute appendicitis, and is more common than acute intestinal obstruction and ulcer perforation. The disease is more common in middle-aged people aged 35 to 40, and women are more likely to suffer from it than men, especially women who are obese and have multiple pregnancies. The onset of acute cholecystitis is due to obstruction of the cystic duct by stones, resulting in the retention of bile in the gallbladde...
Examples
Embodiment 1
[0070] Embodiment 1: the preparation of cefprozil liposome
[0071] Name of raw material
Dose 1 (mg)
Dose 2 (mg)
Dose 3 (mg)
cefprozil
62.50
125.00
250.00
Hydrogenated Soy Lecithin
156.25
312.50
625.00
Hydrogenated egg yolk lecithin
156.25
312.50
625.00
312.50
625.00
1250.00
Vitamin E
50.00
100.00
200.00
total
737.50
1475.00
2950.00
[0072] Preparation:
[0073] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and vitamin E in an appropriate amount of absolute ethanol according to the prescription amount, mix evenly, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, vacuum Dry under reduced pressure. The amount of dehydrated alcohol used is 30 times of the amount of cefprozil.
[0074] (B) Weigh th...
Embodiment 2
[0079] Embodiment 2: the preparation of cefprozil liposome
[0080] Name of raw material
Dose 1 (mg)
Dose 2 (mg)
Dose 3 (mg)
cefprozil
62.50
125.00
250.00
[0081] Hydrogenated Soy Lecithin
256.25
512.50
1025.00
Hydrogenated egg yolk lecithin
256.25
512.50
1025.00
cholesterol
512.50
1025.00
2050.00
Vitamin E
50.00
100.00
200.00
total
1137.50
2275.00
4550.00
[0082] Preparation:
[0083] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and vitamin E in an appropriate amount of absolute ethanol according to the prescription amount, mix evenly, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, vacuum Dry under reduced pressure. The amount of dehydrated alcohol used is 30 times of the amount of cefprozil....
Embodiment 3
[0089] Embodiment 3: the preparation of cefprozil liposome
[0090] Name of raw material
Dose 1 (mg)
Dose 2 (mg)
Dose 3 (mg)
cefprozil
62.50
125.00
250.00
Hydrogenated Soy Lecithin
312.50
625.00
1250.00
Hydrogenated egg yolk lecithin
312.50
625.00
1250.00
cholesterol
625.00
1250.00
2500.00
Vitamin E
50.00
100.00
200.00
total
1362.50
2725.00
5450.00
[0091] Preparation:
[0092] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and vitamin E in an appropriate amount of absolute ethanol according to the prescription amount, mix evenly, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, vacuum Dry under reduced pressure. The amount of dehydrated alcohol used is 30 times of the amount of cefprozil.
[0093] (B) Weig...