Method for preparing cefprozil compound

A technology of cefprozil and compounds, applied in the field of medicine, can solve the problems of complex reaction steps, large isomer content, low product purity, etc., achieve stability and mild activity, small isomer content, and increase reaction yield Effect

Inactive Publication Date: 2012-06-13
HAINAN MEIDA PHARMA
View PDF4 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] About the synthetic method of cefprozil, all have introduction in the patent at home and abroad, its common shortcoming is exactly that reaction step is too complicated, and the product purity that obtains is not high, and isomer content is too high
U.S. Patent No.4694079 discloses a kind of preparation method of cefprozil DMF solvate, not only reaction step is complicated, and yield only has 65%; The separation of isomers by adsorption chromatography is difficult for this method to be implemented on an industrial scale; Chinese patent CN1694888A discloses a preparation method of cefprozil DMF solvate. Big

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing cefprozil compound
  • Method for preparing cefprozil compound
  • Method for preparing cefprozil compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0038] 1, the preparation of cefprozil

[0039] (1) Mix 50 g of 7-phenylacetamido-3-chloromethyl cephalosporanic acid p-methoxybenzyl ester and 28.3 g of triphenylphosphine, add 300 ml of chloroform and 300 ml of water, and react at 60 ° C under nitrogen protection for 3 hour, separate the organic phase, cool to 10°C, then add 200ml of 1mol / L sodium hydroxide solution to react for 3 hours, collect the organic phase, wash with 200ml of water, then add 200ml of chloroform, 250ml of isopropanol and 40% of 130ml of acetaldehyde was stirred and reacted for 16 hours, then 250ml of water was added, stirred for 30 minutes, the organic phase was separated, concentrated under reduced pressure, 100ml of ice water was added, stirred for 3 hours, filtered, and vacuum-dried at 45°C to obtain 7-phenylacetamido-3 -46 g of p-methoxybenzyl (Z-prop-1-enyl)-4-cephalosporanic acid, yield 93.3%.

[0040] (2) Add 136g of phosphorus pentachloride to 625ml of dichloromethane, cool to 15°C, under nitr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a novel route cefprozil compound, which simplifies the processes of 7-phenacetylamino-3-chloromethyl cephalosporanic acid anisyl acetate and triphenylphosphine phyllocaline Benedict's reagents, and activating reagents such as sodium iodide and the like do not need to be added, so the post treatment is simple and convenient, the production amplification can be realized more easily, and at the same time, para hydroxybenzene glycine is adopted to react with 2, 4, 6-trichlorophenol to generate a novel intermediate product of para hydroxybenzene glycine 2, 4, 6- phenyl estertrichlorine. The stability and the activity of the compound are mild, by-products produced in the reaction are fewer, the reaction yield is improved, and in addition, the obtained products have high purity and low isomeride content.

Description

technical field [0001] The invention relates to a new route of cefprozil compound, which belongs to the technical field of medicine. Background technique [0002] Cefprozil, its chemical name is: (6R,7R)-7-[(R)-2-amino-2-(p-hydroxyphenyl)acetamido]-8-oxo-3-propene-5-mercapto -1-azabicyclo-(4.2.0)oct-2-ene-2-carboxylic acid monohydrate, molecular formula: C 18 h 19 N 3 o 5 S·H 2 O, molecular weight: 407.45, structural formula: [0003] [0004] Cefprozil is a second-generation cephalosporin antibiotic with a broad-spectrum antibacterial effect. The mechanism of action is to inhibit the synthesis of bacterial cell walls and rapidly rupture and dissolve the bacteria. It can be used for the following mild and moderate infections caused by sensitive bacteria: 1. Respiratory tract infection: (1) Streptococcus pyogenes pharyngitis, tonsillitis. (2) Streptococcus pneumoniae, Haemophilus influenzae (including β-lactamase-producing strains) and Moraxella catarrhalis (includi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C07D501/22C07D501/04C07C229/36C07C227/18
Inventor 邱民
Owner HAINAN MEIDA PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap