Cefprozil dry suspension and preparation method thereof

A technology of cefprozil and dry suspension, which is applied in the direction of medical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of inability to guarantee the curative effect of drugs, inaccurate dosage, and preparation process Complicated problems, to achieve the effect of good suspension effect, good dissolution rate and simple process

Active Publication Date: 2013-12-11
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has poor dispersion, resulting in inaccurate dosage and no way to guarantee the efficacy of the drug
[0005] In summary, the above methods all have complex preparation processes, require special equipment for production, and have a long production cycle. From the perspective of long-term energy consumption and cost, it is necessary to develop a simple process that can be completed without any special equipment. method

Method used

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  • Cefprozil dry suspension and preparation method thereof
  • Cefprozil dry suspension and preparation method thereof
  • Cefprozil dry suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] prescription:

[0034]

[0035] Preparation:

[0036] Take 1720g of sucrose, 4g of hypromellose K4M and 200g of hypromellose sodium in the mixer and mix evenly in the above prescription, then add 50g of micropowdered silica gel and 8g of 60% ethanol (8g is the quality of 60% ethanol, the following the same), put it in a mixing wet granulator and mix evenly, dry at low temperature, put it in a multi-directional mixer and mix evenly, add 63g of aspartame, 6g of strawberry essence, and 200g of cefprozil, mix evenly, and pack it separately to get cefprozil dry suspension.

Embodiment 2

[0038] prescription:

[0039]

[0040]

[0041] Preparation:

[0042] Take 2150g of sucrose, 10g of hypromellose K4M and 220g of hypromellose sodium in a mixer and mix them evenly in the mixer, then add 55g of micropowder silica gel and 10g of 60% ethanol, and mix them in a mixing wet granulator Uniformly, dry at low temperature, place in a multi-directional mixer to mix evenly, add 70g of aspartame, 10g of strawberry essence and 250g of cefprozil, mix evenly, and pack separately to obtain cefprozil dry suspension.

Embodiment 3

[0044] prescription:

[0045]

[0046] Preparation:

[0047] Take 4800g of sucrose, 13g of hypromellose K4M and 260g of hypromellose sodium in a mixer and mix them evenly in the mixer, then add 65g of micropowder silica gel and 24g of 60% ethanol, and mix them in a mixing wet granulator Uniformly, dry at low temperature, place in a multi-directional mixer to mix evenly, add 82g of aspartame, 13g of strawberry essence and 600g of cefprozil, mix evenly, and pack separately to obtain cefprozil dry suspension.

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Abstract

The invention discloses a cefprozil dry suspension which is composed of the following raw materials by weight: 1.0%-5.0% of cefprozil, 10%-60% of a filler, 1.0%-4.0% of hydroxypropyl methylcellulose K4M, 0.2%-0.5% of carboxymethylcellulose sodium, 0.2%-0.4% of a lubricant, 0.2%-0.5% of a sweetener, 0.3%-0.8% of an aromatic and proper amount of ethanol. The invention also discloses a preparation method of the cefprozil dry suspension. The preparation method comprises: firstly preparing blank particles, then mixing uniformly with main drugs, performing sub-packaging, and combining with specific auxiliary materials to improve product mouthfeel, sedimentation volume ratio and redispersibility. The cefprozil dry suspension is avoided in the phenomenon that the content of correlated materials is raised because the main drugs are heated; and the preparation method is simple, no special equipment is needed, and the preparation method is applicable to industrialized production.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a cefprozil dry suspension and a preparation method thereof. Background technique [0002] Cefprozil is a second-generation cephalosporin drug with broad-spectrum antibacterial activity. The bactericidal effect of the drug is to hinder the synthesis of bacterial cell walls. In vitro tests have shown that cefprozil has obvious effects on Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes in Gram-positive aerobic bacteria, and has obvious effects on Haemophilus influenzae and Moraxella catarrhalis in Gram-negative aerobic bacteria. etc. are highly sensitive; it can treat upper and lower respiratory tract infections, skin and soft tissue infections caused by the above-mentioned sensitive bacteria, has good curative effect, has few side effects, and is reasonably priced, so it is worth popularizing. Domestic trials have proved that the tablets and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/545A61K47/38A61K47/26A61P31/04
Inventor 刘全国陈克领
Owner HAINAN HULUWA PHARMA GRP CO LTD
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