Cefprozil dry suspension and preparation method thereof

Abstract

The invention discloses a cefprozil dry suspension which is composed of the following raw materials by weight: 1.0%-5.0% of cefprozil, 10%-60% of a filler, 1.0%-4.0% of hydroxypropyl methylcellulose K4M, 0.2%-0.5% of carboxymethylcellulose sodium, 0.2%-0.4% of a lubricant, 0.2%-0.5% of a sweetener, 0.3%-0.8% of an aromatic and proper amount of ethanol. The invention also discloses a preparation method of the cefprozil dry suspension. The preparation method comprises: firstly preparing blank particles, then mixing uniformly with main drugs, performing sub-packaging, and combining with specific auxiliary materials to improve product mouthfeel, sedimentation volume ratio and redispersibility. The cefprozil dry suspension is avoided in the phenomenon that the content of correlated materials is raised because the main drugs are heated; and the preparation method is simple, no special equipment is needed, and the preparation method is applicable to industrialized production.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a cefprozil dry suspension and a preparation method thereof. Background technique [0002] Cefprozil is a second-generation cephalosporin drug with broad-spectrum antibacterial activity. The bactericidal effect of the drug is to hinder the synthesis of bacterial cell walls. In vitro tests have shown that cefprozil has obvious effects on Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes in Gram-positive aerobic bacteria, and has obvious effects on Haemophilus influenzae and Moraxella catarrhalis in Gram-negative aerobic bacteria. etc. are highly sensitive; it can treat upper and lower respiratory tract infections, skin and soft tissue infections caused by the above-mentioned sensitive bacteria, has good curative effect, has few side effects, and is reasonably priced, so it is worth popularizing. Domestic trials have proved that the tablets and...

AI Technical Summary

Problems solved by technology

This method has poor dispersion, resulting in inaccurate dosage and no way to guarantee the efficacy of the drug

[0005] In summary, the above methods all have complex preparation processes, require special equipment for production, and have a long production cycle. From the perspective of long-term energy consumption and cost, it is necessary to develop a simple process that can be completed without any special equipment. method

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