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Cefprozil dispersible tablet and preparation method thereof

A technology for cefprozil and dispersible tablets, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. simple craftsmanship

Active Publication Date: 2013-05-22
GUANGDONG BOZHOU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the scheme disclosed in the above-mentioned documents, no matter the cefprozil dispersible tablet or composition granulated by dry method or wet method, the role of pharmaceutical excipients such as disintegrating agent and disintegrating agent cannot be underestimated.

Method used

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  • Cefprozil dispersible tablet and preparation method thereof
  • Cefprozil dispersible tablet and preparation method thereof
  • Cefprozil dispersible tablet and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0038] 1. Prescription

[0039]

[0040] 2. Preparation method

[0041] a) micronized treatment of cefprozil to a powder with a particle size of 60 μm-150 μm;

[0042] b) Microcrystalline cellulose, micronized lactose or pregelatinized starch, hydroxypropyl cellulose, and sodium lauryl sulfate are respectively passed through an 80-mesh sieve, and then passed through a 60-mesh sieve to make the mixture uniform;

[0043] c) extruding the above-mentioned materials into lumps by dry method, crushing, granulating with 18 mesh sieves, and granulating with 16 mesh sieves;

[0044] d) Add prescription amount of magnesium stearate and stevioside, mix and compress into tablets to obtain.

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Abstract

The invention relates to a preparation method of a medicinal preparation taking cefprozil as a main ingredient, and in particular relates to a preparation method of a cefprozil dispersible tablet with higher bioavailability. The method comprises the following steps of: taking the cefprozil in a therapeutic dose as a main active medicine ingredient; micronizing the cefprozil; adding an additive in proper quantity into the cefprozil to be pelletized by using a dry method; and pressing a pellet into the tablet. The cefprozil dispersible tablet comprises the following ingredients in parts by weight: 250+ / -5 parts of the cefprozil, 180+ / -20 parts of microcrystalline cellulose, 100+ / -10 parts of micronized lactose or pregelatinized starch, 30+ / -3 parts of hydroxypropyl cellulose; 5+ / -2 parts of lauryl sodium sulfate, 2.5+ / -1 parts of magnesium stearat and 2.5+ / -1 parts of stevioside, wherein the micronized cefprozil is in the shape of powder with the particle diameter of 60 to 150 mu m. The method provided by the invention has the advantages that the production process is simple; and the prepared cefprozil dispersible tablet is high in dissolution rate and stable in quality.

Description

technical field [0001] The invention relates to a pharmaceutical preparation with cefdinir as the main component in the technical field of pharmaceutical preparations and a preparation method thereof, in particular to a cefprozil dispersible tablet and a preparation method thereof. Background technique [0002] Cefprozil (cefprozil), chemical name: (6R,7R)-3-propenyl-7-[(R)-2-amino-2-(4-hydroxyphenyl)acetamido]-8-oxo- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate. It is a non-ester oral cephalosporin developed by Bristol-Myers Tokyo Research Institute in 1983. Its molecular structure is related to cephalexin, cefadroxil and cefaclor. There is a p-hydroxyphenylglycine substituent at the 7-position of the cephalosporin nucleus, and a propenyl side chain at the 3-position. Its structural formula is as follows: [0003] [0004] Its molecular formula is: C 18 h 19 N 3 o 5 S·H 2 O, molecular weight: 407.44. [0005] The antibacterial spectrum of ce...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/545A61K47/38A61P31/04
Inventor 符永峰詹夏冰王德农
Owner GUANGDONG BOZHOU PHARMA
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