Cefprozil submicron emulsion solid preparation and new application thereof

A technology of propylene submicron emulsion and cefprozil, which is applied in the field of medicine, can solve the problems of low dissolution rate and poor stability of cefprozil solid preparation, and achieve the effects of increasing solubility, reducing drug side effects, and simple production process

Inactive Publication Date: 2010-05-05
HAINAN LINGKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The object of the present invention is to provide a kind of cefprozil submicroemulsion particle and the solid preparation comprising the submicroemulsion particle and new application thereof, which solves the problems of poor stability and low dissolution rate of cefprozil solid preparation, and can also be used Satisfactory technical results have been obtained in the preparation of drugs for the treatment of acute plasma cell mastitis

Method used

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  • Cefprozil submicron emulsion solid preparation and new application thereof
  • Cefprozil submicron emulsion solid preparation and new application thereof
  • Cefprozil submicron emulsion solid preparation and new application thereof

Examples

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Embodiment 1

[0025] The preparation of embodiment 1 cefprozil submicroemulsion particles

[0026] Add 640g of egg yolk lecithin, 400g of poloxamer 188 and 280g of sodium deoxycholate into 10,000ml of water for injection, then add 100g of cefprozil and mix evenly, heat and stir in a water bath at 80°C for 30min until it melts, and cut it with a tissue masher Stir for 20 minutes at a speed of 13000r / min to obtain the primary emulsion, and then circulate and emulsify through a high-pressure homogenizer for 5 times to obtain an emulsion, then freeze-dry in a large plate, and pulverize to obtain 1326 g of submicron emulsion particles of cefprozil, with a yield of 93.4%.

Embodiment 2

[0027] The preparation of embodiment 2 cefprozil submicroemulsion particles

[0028] Add 320g of egg yolk lecithin, 200g of poloxamer 188 and 160g of sodium deoxycholate into 4000ml of water for injection, then add 100g of cefprozil and mix evenly, heat and stir in a water bath at 90°C for 40min until it melts, and cut it with a tissue masher Stir for 10 min at a speed of 15000 r / min to obtain the primary emulsion, then circulate and emulsify through a high-pressure homogenizer for 6 times to obtain an emulsion, then freeze-dry in a large plate, and pulverize to obtain 734 g of submicron emulsion particles of cefprozil, with a yield of 94.1%.

Embodiment 3

[0029] The preparation of embodiment 3 cefprozil submicron emulsion particles

[0030]Add 800g of egg yolk lecithin, 500g of poloxamer 188 and 380g of sodium deoxycholate into 4000ml of water for injection, then add 100g of cefprozil and mix evenly, heat and stir in a water bath at 70°C for 60 minutes until it melts, and cut it with a tissue masher Stir for 20 minutes at a rotational speed of 12000r / min to obtain the primary emulsion, and then circulate emulsification through a high-pressure homogenizer for 5 times to obtain an emulsion, and then spray dry to obtain 1648 g of submicron emulsion particles of cefprozil, with a yield of 92.6%.

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Abstract

The invention relates to a cefprozil submicron emulsion solid preparation and new application thereof in the preparation of medicine for treating acute plasma cell mastitis. The cefprozil submicron emulsion granule comprises cefprozil, yolk lecithin, poloxamer 188 and deoxysodium cholate with the weight ratio of 1:2.3-14:1.2-8:0.8-10.

Description

technical field [0001] The invention relates to a cefprozil submicroemulsion particle, a solid preparation containing the submicroemulsion particle and a new application thereof, belonging to the technical field of medicine. Background technique [0002] Plasma cell mastitis, also known as mammary duct ectasia, is not uncommon in clinical practice. It is divided into acute phase, subacute phase and chronic phase according to the composition. At present, it is considered that the main cause of the disease is nipple inversion, irregular hyperplasia of mammary ducts, etc., which make the discharge of secretions in the milk ducts blocked or the secretion function of the milk ducts is abnormal. A large amount of lipid secretions accumulate in the milk ducts, causing the expansion of the milk ducts. The permeability of the wall increases, and the lipid-like secretion penetrates into the interstitium of the mammary gland through the milk duct wall, triggering a local immune respon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/545A61K47/24A61K47/28A61K47/34A61P31/04A61K47/10
Inventor 陶灵刚
Owner HAINAN LINGKANG PHARMA CO LTD
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