41results about How to "Solve the problem of low dissolution rate" patented technology

The invention relates to a cefixime submicro-emulsion solid preparation and a novel application thereof, in particular to a solid preparation of cefixime processed by micro-emulsification and a novel application thereof. The cefixime submicro-emulsion solid preparation comprises cefixime, an emulsifying agent and an emulsifying aid agent, wherein the active component of the cefixime is processed by applying a micro-emulsification technology. The stability is enhanced, the solubility is increased, and the problem of low leaching degree is solved.

The invention relates to a tablet composition containing alogliptin benzoate. It is characterized in that every 1000 tablets contain alogliptin benzoate 34g, silicon dioxide 2-12g, mannitol 30-77.5g, microcrystalline cellulose 25-62.5g, croscarmellose sodium 6g, hydroxyl Propylene cellulose 4g, magnesium stearate 1.5g, Opadry coating powder appropriate amount. Through reasonable compatibility, the present invention adopts the direct compression process, which simplifies the production process, shortens the production time, improves the production efficiency and improves the product stability compared with the traditional wet granulation process.

The invention discloses a proglumide pharmaceutical composition. The pharmaceutical composition is characterized in that each 1000 tablets contain the following components in percentage by weight: 190-210 parts of proglumide, 40-210 parts of calcium hydrogen phosphate, 1-5 parts of magnesium stearate and 0-5 parts of a binding agent. A preparation method of the composition comprises the following steps. The pharmaceutical composition disclosed by the invention has advantages that the calcium hydrogen phosphate, which is alkaline, serves as an accessory material, and the proglumide is slightly soluble in water but is solution in an alkaline solution. By virtue of the alkaline accessory material, various quality indexes of a finished product are kept basically stable within a valid period, and moreover the dissolution rate of the product is improved. The calcium hydrogen phosphate, which serves an accessory material, can accelerate disintegration of the finished product while addition of a disintegrating agent, so that cost of the finished product can be reduced.

The invention belongs to the technical field of surface treatment of medical equipment and relates to a stainless steel matte finishing process. The primary technical scheme is as follows: the stainless steel matte finishing process comprises the following steps: placing a deoiled stainless steel workpiece and the anode of a power supply connected in an anodizing matte finishing solution of a mixture containing 10-50 g / L H3PO4, 10-30 g / L C6H8O7, 100-300 g / L H2O2 and 0.4-1 g / L K2SO4; heating the solution to 60-80 DEG C and connecting a platinum and titanium net to the cathode of a direct current power supply, wherein the area ratio of the platinum and titanium net and the cathode of the direct current power supply is 1: 1; and keeping the distance between the cathode and the anode at 6.0 cm, carrying out anodizing for 30-60 min under the condition that the current density is 3.4-6.8 A / dm<2> and the working voltage is 9.4-10.5 V, wherein the surface of stainless steel workpiece is matteand has silver metal gloss, the hardness of the stainless steel is improved, and the pitting corrosion resistance is improved. The stainless steel matte finishing process provided by the invention notonly can solve the environmental problem that an existing stainless steel matte finishing solution contains harmful substances and strong acids, but also can solve the problem that the dissolving speed of the environment-friendly solution is low, thereby providing a new path for development of stainless steel matte technical treatment.

The invention discloses an infantile domperidone orally disintegrating tablet and a preparation method thereof. The orally disintegrating tablet is prepared from the following raw materials in parts by mass: 10 to 30 parts of domperidone, 10 to 30 parts of fatty glyceride, 5 to 10 parts of tween 80, 900 to 2700 parts of white sugar, 2 to 5 parts of crospovidone, 10 to 30 parts of mannitol, 0.01 to 0.05 part of essence, 0.2 to 0.5 part of magnesium stearate and 0.2 to 0.5 part of aerosil. According to the infantile domperidone orally disintegrating tablet and the preparation method thereof, an orally disintegrating tablet medicament is prepared by using the domperidone as an effective component of the medicament and through an innovative process. By using the domperidone orally disintegrating tablet prepared by the invention, the problems that the dissolution rate of the medicament is low, the medicament has a bitter taste, and the like, are solved successfully; the infantile domperidone orally disintegrating tablet has a favorable effect on infantile functional dyspepsia.