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Solid cefdinir sub-microemulsion and new application thereof

A solid preparation, cefdinir technology, applied in cefdinir microemulsion solid preparation and its new application field, can solve the problems of poor stability and low dissolution rate, achieve low cost, increase solubility, and improve stability Effect

Inactive Publication Date: 2010-06-09
HAINAN MEIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The object of the present invention is to provide a kind of cefdinir microemulsion solid preparation and its new application, specifically, the solid preparation of cefdinir and its new application through the microemulsification process, well solved the cefdinir currently on the market The problems of poor stability and low dissolution rate of dinis solid preparations can also be used to prepare drugs for the treatment of cystic acne, and a satisfactory technical effect has been obtained

Method used

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  • Solid cefdinir sub-microemulsion and new application thereof
  • Solid cefdinir sub-microemulsion and new application thereof
  • Solid cefdinir sub-microemulsion and new application thereof

Examples

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Effect test

Embodiment 1

[0042] The preparation of embodiment 1 cefdinya microemulsion particles

[0043] Add 267g of soybean lecithin, 53g of povidone K30 and 160g of glycerin into 3000ml of water for injection, then add 100g of cefdinir and mix evenly, heat and stir in a water bath at 80°C until it melts, and use a tissue masher to shear and stir for 10min at a speed of 15000r / min, to obtain the first emulsion, and then emulsified 5 times through a high-pressure homogenizer cycle to obtain an emulsion, then freeze-dried in a large plate, and pulverized to obtain 544g of submicroemulsion particles of cefdinir, with a yield of 93.8%.

Embodiment 2

[0046] The preparation of embodiment 2 cefdinya microemulsion particles

[0047] Add 625g of soybean lecithin, 125g of povidone K30 and 400g of glycerin into 8000ml of water for injection, then add 100g of cefdinir and mix evenly, heat and stir in a water bath at 70°C until it melts, and use a tissue masher to shear and stir for 20min at a speed of 13000r / min, to obtain the first emulsion, and then circulate emulsified 5 times through a high-pressure homogenizer to obtain an emulsion, which is then spray-dried to obtain 1178 g of submicroemulsion particles of cefdinir, with a yield of 94.2%.

Embodiment 3

[0050] The preparation of embodiment 3 cefdinya microemulsion particles

[0051] Add 450g of soybean lecithin, 90g of povidone K30 and 280g of glycerin into 5500ml of water for injection, then add 100g of cefdinir and mix evenly, heat and stir in a water bath at 90°C until it melts, and use a tissue masher to shear and stir for 15min at a speed of 15000r / min, to obtain the primary emulsion, and then emulsify 5 times through a high-pressure homogenizer cycle to obtain an emulsion, and then spray-dry to obtain 852 g of submicron emulsion particles of cefdinir, with a yield of 92.6%.

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Abstract

The invention provides a solid cefdinir sub-microemulsion prepared from cefdinir sub-microemulsion particles and a pharmaceutically acceptable excipient and new application thereof. The cefdinir sub-microemulsion particle comprises the following components by weight part: 1 part of cefdinir, 2 to 15 parts of emulsifier and 0.5 to 9 parts of assistant emulsifier.

Description

technical field [0001] The invention relates to a cefdinir microemulsion solid preparation and its new application, in particular to a microemulsified cefdinir solid preparation and its new application. Background technique [0002] Acne is a chronic inflammation of the pilosebaceous glands, which is prone to occur in adolescence and mainly occurs in areas rich in sebaceous glands such as the face, chest, and back. Clinically, according to the number and type of skin lesions, acne can be divided into 4 grades, grade I mainly acne, grade II mainly acne and moderate papules, grade III mainly papules and pustules, grade IV Mostly nodules / cysts. Its pathogenesis mainly includes increased secretion of sebaceous glands, abnormal hair follicle differentiation and hyperkeratosis, and excessive bacterial proliferation. Propionibacterium acnes plays a central role in multiple pathogenic factors of acne. Cystic acne is mainly related to gonad secretion dysfunction, excessive sebaceou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/20A61K9/46A61K9/48A61K47/32A61K47/36A61K47/38A61K47/42A61K31/546A61P17/10A61K47/10A61K47/14A61K47/24A61K47/26A61K47/44
Inventor 王明
Owner HAINAN MEIDA PHARMA
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