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Canagliflozin composition

A technology of canagliflozin and composition, which is applied in the field of pharmaceutical preparations and can solve problems such as low dissolution rate of preparations and unstable substances

Inactive Publication Date: 2018-03-02
WEIHAI GUANBIAO INFORMATION TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a canagliflozin composition, which solves the technical problem of low dissolution of preparations and the instability of related substances

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1. 100g of canagliflozin with a D90 of 36 microns, 70g of lactose, 0.8g of sodium lauryl sulfate, 7g of sodium citrate, 3g of sodium carbonate, 10g of β-cyclodextrin, 3g of povidone K30, cross-linked Povidone 8g, magnesium stearate 1g. Prepare 1000 tablets according to the preparation method described in the technical scheme.

Embodiment 2

[0024] Example 2. Canagliflozin 300g with a D90 of 60 microns, 40g lactose, 1.5g sodium lauryl sulfate, 15g sodium citrate, 6g sodium carbonate, 18g beta cyclodextrin, 8g povidone K30, cross-linked Povidone 3g, magnesium stearate 1.5g. Prepare 1000 tablets according to the preparation method described in the technical scheme.

Embodiment 3

[0025] Embodiment 3. D90 is 100g of canagliflozin of 48 microns, 55g of lactose, 1.2g of sodium lauryl sulfate, 10g of sodium citrate, 4.5g of sodium carbonate, 14g of beta cyclodextrin, povidone K30 5, Lipovidone 5g, magnesium stearate 1.2g. Prepare 1000 tablets according to the preparation method described in the technical scheme.

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PUM

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Abstract

The invention relates to a Canagliflozin tablet composition, and belongs to the technical field of medicine preparations. The technical scheme is that the unit dose of Canagliflozin composition is prepared from 100 to 300 mg of canagliflozin with D90 being 36 to 60 micrometers, 40 to 70 mg of lactose, 0.8 to 1.5 mg of lauryl sodium sulfate, 7 to 15 mg of sodium citrate, 3 to 6 mg of sodium carbonate, 10 to 18 mg of beta-cyclodextrin, 3 to 8 mg of povidone K30, 3 to 8 mg of polyvinylpolypyrrolidone and 1 to 1.5mg of magnesium stearate. The technical scheme provides the Canagliflozin tablet composition with the advantages of high dissolution rate and stability.

Description

technical field [0001] The invention relates to a canagliflozin tablet composition, which belongs to the technical field of pharmaceutical preparations. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia. According to statistics from the International Diabetes Federation, there were 387 million people with diabetes worldwide in 2014, and it is expected to reach 592 million in 2035. Type 2 diabetes is the most common form of diabetes, accounting for approximately 90% of diabetic patients. [0003] Diabetes can lead to chronic damage and dysfunction of various tissues in the human body, especially the eyes, kidneys, heart, blood vessels, and nerves. Once you become a diabetic, you need to take medicine for life. Diabetes not only affects the quality of life of patients, but may also lead to shortened life expectancy. [0004] Canagliflozin, also known as canagliflozin, English name Canagliflozin, trade name Invokana, deve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/381A61K47/40A61K47/04A61K47/12A61K47/20A61P3/10
CPCA61K31/381A61K9/2009A61K9/2013A61K9/205
Inventor 孙爱梅
Owner WEIHAI GUANBIAO INFORMATION TECH
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