Canagliflozin composition
A technology of canagliflozin and composition, which is applied in the field of pharmaceutical preparations and can solve problems such as low dissolution rate of preparations and unstable substances
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Embodiment 1
[0023] Example 1. 100g of canagliflozin with a D90 of 36 microns, 70g of lactose, 0.8g of sodium lauryl sulfate, 7g of sodium citrate, 3g of sodium carbonate, 10g of β-cyclodextrin, 3g of povidone K30, cross-linked Povidone 8g, magnesium stearate 1g. Prepare 1000 tablets according to the preparation method described in the technical scheme.
Embodiment 2
[0024] Example 2. Canagliflozin 300g with a D90 of 60 microns, 40g lactose, 1.5g sodium lauryl sulfate, 15g sodium citrate, 6g sodium carbonate, 18g beta cyclodextrin, 8g povidone K30, cross-linked Povidone 3g, magnesium stearate 1.5g. Prepare 1000 tablets according to the preparation method described in the technical scheme.
Embodiment 3
[0025] Embodiment 3. D90 is 100g of canagliflozin of 48 microns, 55g of lactose, 1.2g of sodium lauryl sulfate, 10g of sodium citrate, 4.5g of sodium carbonate, 14g of beta cyclodextrin, povidone K30 5, Lipovidone 5g, magnesium stearate 1.2g. Prepare 1000 tablets according to the preparation method described in the technical scheme.
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