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Orally disintegrating domperidone tablet for children and preparation method thereof

A technology of dipperidone orally disintegrating tablets and domperidone, which is applied in the field of medicine and can solve the problems of bitterness of drugs and low dissolution rate of drugs

Active Publication Date: 2018-07-06
SHANDONG SBOND PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the deficiencies of the prior art, the present invention provides a domperidone orally disintegrating tablet for children and a preparation method thereof. Through innovative selection of excipients, optimized ratio of excipients and innovative preparation process, the low dissolution rate of the drug and the bitterness of the drug are successfully solved. question

Method used

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  • Orally disintegrating domperidone tablet for children and preparation method thereof
  • Orally disintegrating domperidone tablet for children and preparation method thereof
  • Orally disintegrating domperidone tablet for children and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0176] Embodiment 1, a kind of preparation method of orally disintegrating tablet of domperidone for children

[0177] 1. A domperidone orally disintegrating tablet for children is made of the following raw materials in parts by mass:

[0178]

[0179] 2. The preparation method is as follows:

[0180] (1) Domperidone is pulverized and passed through a 150-mesh sieve to obtain an average particle size of 28-32 μm, which is set aside;

[0181] (2) pulverize the white sugar and polyvinylpolypyrrolidone of proportioning amount, cross 110 mesh sieves, and set aside;

[0182] (3) Melt fatty acid glycerides at 60-80°C, add the proportioning amount of Tween 80 and mix well, then weigh the proportioning amount of domperidone, then add the proportioning amount of 1 / 3 (W / W) white sugar, After cooling and solidifying, pulverize through a 15-mesh sieve;

[0183] (4) Dissolving mannitol in deionized water to prepare a 55% (W / W) mixed solution, then adding the materials in step (3), fu...

Embodiment 2

[0186] Embodiment 2, a kind of preparation method of children's domperidone orally disintegrating tablet

[0187] 1. A domperidone orally disintegrating tablet for children is made of the following raw materials in parts by mass:

[0188]

[0189]

[0190] 2. The preparation method is as follows:

[0191] (1) Domperidone is pulverized and passed through a 160-mesh sieve to obtain particles with an average particle diameter of 21-24 μm for subsequent use;

[0192] (2) Pulverize white sugar and polyvinylpolypyrrolidone of proportioning amount, cross 100 mesh sieves, and set aside;

[0193] (3) Melt the fatty acid glyceride at 60-80°C, add the proportioning amount of Tween 80 and mix well, then weigh the proportioning amount of domperidone, then add the proportioning amount of 1 / 3 (W / W) white sugar, After cooling and solidifying at room temperature, pulverize through a 20-mesh sieve;

[0194] (4) dissolving mannitol in deionized water to prepare a mixed solution of 60% (...

Embodiment 3

[0197] Embodiment 3, a kind of preparation method of children's domperidone orally disintegrating tablet

[0198] 1. A domperidone orally disintegrating tablet for children is made of the following raw materials in parts by mass:

[0199]

[0200] 2. The preparation method is as follows:

[0201] (1) Domperidone is pulverized and passed through a 155-mesh sieve to obtain particles with an average particle diameter of 24-28 μm for subsequent use;

[0202] (2) Pulverize the white sugar and polyvinylpolypyrrolidone of proportioning amount, cross 120 mesh sieves, and set aside;

[0203] (3) Melt the fatty acid glyceride at 60-80°C, add the proportioning amount of Tween 80 and mix well, then weigh the proportioning amount of domperidone, then add the proportioning amount of 1 / 3 (W / W) white sugar, After cooling and solidifying at room temperature, pulverize through a 10-mesh sieve;

[0204] (4) dissolving mannitol in deionized water to prepare a mixed solution of 50% (W / W), th...

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Abstract

The invention discloses an infantile domperidone orally disintegrating tablet and a preparation method thereof. The orally disintegrating tablet is prepared from the following raw materials in parts by mass: 10 to 30 parts of domperidone, 10 to 30 parts of fatty glyceride, 5 to 10 parts of tween 80, 900 to 2700 parts of white sugar, 2 to 5 parts of crospovidone, 10 to 30 parts of mannitol, 0.01 to 0.05 part of essence, 0.2 to 0.5 part of magnesium stearate and 0.2 to 0.5 part of aerosil. According to the infantile domperidone orally disintegrating tablet and the preparation method thereof, an orally disintegrating tablet medicament is prepared by using the domperidone as an effective component of the medicament and through an innovative process. By using the domperidone orally disintegrating tablet prepared by the invention, the problems that the dissolution rate of the medicament is low, the medicament has a bitter taste, and the like, are solved successfully; the infantile domperidone orally disintegrating tablet has a favorable effect on infantile functional dyspepsia.

Description

technical field [0001] The invention relates to a drug for gastrointestinal motility, in particular to an orally disintegrating tablet of domperidone for children and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Domperidone is a synthetic benzoimidazole derivative, it is a dopamine receptor antagonist with anti-emetic effect, and it is difficult to enter the brain through the blood-brain barrier. Domperidone acts on the chemoreceptor trigger area outside the blood-brain barrier, so it hardly acts on the central nervous system; domperidone selectively blocks dopamine 2 (DA2) receptors and mainly acts on the peripheral nervous system. Since DA2 receptors are also the main receptors in the gastrointestinal tract, DA2 receptor antagonists reduce dopamine-mediated relaxation of gastric smooth muscle. In the gastrointestinal tract, domperidone acts as a prokinetic agent, increasing the motility of the digestive tract. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/454A61K47/14A61K47/26A61P1/14
CPCA61K9/0056A61K9/2013A61K9/2018A61K9/2027A61K31/454
Inventor 乔敏袁武杰
Owner SHANDONG SBOND PHARMA
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