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Cefixime submicro-emulsion solid preparation and novel application thereof

A technology of cefixime and solid preparations, which is applied in the field of medicine, can solve the problems of low dissolution rate and poor stability, and achieve the effects of increasing solubility, low cost and simple production process

Inactive Publication Date: 2010-05-26
HAINAN MEIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to provide a kind of cefixime submicroemulsion solid preparation and its new application, specifically, the solid preparation of cefixime through microemulsification treatment and its new application, well solve the problem of cefixime currently on the market. The problem of poor stability and low dissolution rate of gramoxime solid preparations, and it can also be used to prepare medicines for treating acute furunculosis in children, and satisfactory technical results have been obtained

Method used

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  • Cefixime submicro-emulsion solid preparation and novel application thereof
  • Cefixime submicro-emulsion solid preparation and novel application thereof
  • Cefixime submicro-emulsion solid preparation and novel application thereof

Examples

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Effect test

Embodiment 1

[0028] The preparation of embodiment 1 cefixime submicron emulsion particles

[0029] Add 160.7g of soybean lecithin, 89.3g of poloxamer 188 and 80g of sodium deoxycholate into 2500ml of water for injection, then add 100g of cefixime and mix evenly, heat and stir in a water bath at 86°C until it melts, and use a tissue masher Shearing and stirring for 20min, rotating speed 12000r / min, to obtain the primary emulsion, and then emulsifying 5 times through a high-pressure homogenizer cycle to obtain an emulsion, then freeze-drying in a large plate, pulverizing, and obtaining 396.6g of submicron emulsion particles of cefixime, yield 92.2%.

Embodiment 2

[0030] The preparation of embodiment 2 cefixime submicron emulsion particles

[0031] Add 642.9g of soybean lecithin, 357.1g of poloxamer 188 and 500g of sodium deoxycholate into 9000ml of water for injection, then add 100g of cefixime and mix evenly, heat and stir in a 75°C water bath until it melts, and use a tissue masher Shearing and stirring for 15 minutes, rotating speed 13000r / min, to obtain the primary emulsion, and then cyclic emulsification by a high-pressure homogenizer for 5 times to obtain an emulsion, and then spray drying to obtain 1467g of submicron emulsion particles of cefixime, with a yield of 91.7%.

Embodiment 3

[0032] The preparation of embodiment 3 cefixime tablets

[0033] The 44.2g cefixime submicroemulsion granules prepared in Example 1, 56g pregelatinized starch, 70g lactose and 9g low-substituted hydroxypropyl cellulose were respectively passed through an 80 mesh sieve, then mixed uniformly, and 8% povidone K3070% was added 30ml of ethanol solution is used to make soft material, granulated with 20 mesh sieve, dried at 55°C, granulated with 20 mesh sieve, then added with 1.8g of magnesium stearate, mixed evenly, and compressed into tablets to obtain cefixime tablets.

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Abstract

The invention relates to a cefixime submicro-emulsion solid preparation and a novel application thereof, in particular to a solid preparation of cefixime processed by micro-emulsification and a novel application thereof. The cefixime submicro-emulsion solid preparation comprises cefixime, an emulsifying agent and an emulsifying aid agent, wherein the active component of the cefixime is processed by applying a micro-emulsification technology. The stability is enhanced, the solubility is increased, and the problem of low leaching degree is solved.

Description

technical field [0001] The invention relates to a cefixime submicroemulsion solid preparation and its new application, in particular to a microemulsified cefixime solid preparation and its new application, belonging to the technical field of medicine. Background technique [0002] Furuncle is an acute purulent infection of a single hair follicle and its associated sebaceous glands caused by bacterial invasion from the hair follicle or sweat gland. A single person is called furunculosis, and those who repeatedly send out are called furunculosis. The disease is more common in the hot season, often in the head, face, neck, armpits and buttocks and other parts that are often subject to friction. It is common in malnourished children or diabetic patients. Initially, it was an inflammatory papule similar to hair follicles, and gradually increased to pink or dark red infiltrating nodules, with pain and tenderness. After 2-3 days, the nodules purulent, necrotic, and softened, form...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/20A61K9/48A61K9/00A61K31/546A61K47/42A61K47/38A61K47/36A61K47/34A61K47/32A61P31/04A61P17/02A61K47/10A61K47/18
Inventor 陶灵刚
Owner HAINAN MEIDA PHARMA
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