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Proglumide pharmaceutical composition

A technology of proglumide and composition, applied in the field of pharmaceutical preparations, can solve the problems of low dissolution rate, different preparation process, short storage time of medicines, etc., achieve stable quality index and solve the effect of low dissolution rate

Active Publication Date: 2016-01-06
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, the ingredients of excipients were mainly dextrin, starch, etc., but due to different excipients and different preparation processes, there were shortcomings such as short storage time and low dissolution rate of drugs.

Method used

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  • Proglumide pharmaceutical composition
  • Proglumide pharmaceutical composition
  • Proglumide pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 proglumide tablet

[0029] Recipe: as figure 1 .

[0030] Preparation method: weigh proglumide and calcium hydrogen phosphate according to the parts by weight of the components; pulverize proglumide and calcium hydrogen phosphate respectively and pass through 100 mesh sieves respectively, add 5% polyethylene in a tank mixer Pyrrolidone (PVPK30) 40% ethanol was stirred and mixed for 40 minutes to make a soft material, passed through a 18-mesh sieve and granulated; spread the prepared granules evenly on the baking tray with a thickness of 1-1.5cm, and then put the granules on the baking tray Place in a hot air circulation drying oven, dry at 60°C-65°C until dry, and control the water content at 1%-3%; after drying, cool, pass the granules through a 20-mesh sieve for granulation, add magnesium stearate, and displace Mix in a mixer for 15 minutes, and compress the mixed granules into tablets. During the production process, every 15 minutes...

Embodiment 2

[0032] Recipe: as figure 2 .

[0033] The preparation method is the same as in Example 1.

Embodiment 3

[0035] Recipe: as image 3 .

[0036] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a proglumide pharmaceutical composition. The pharmaceutical composition is characterized in that each 1000 tablets contain the following components in percentage by weight: 190-210 parts of proglumide, 40-210 parts of calcium hydrogen phosphate, 1-5 parts of magnesium stearate and 0-5 parts of a binding agent. A preparation method of the composition comprises the following steps. The pharmaceutical composition disclosed by the invention has advantages that the calcium hydrogen phosphate, which is alkaline, serves as an accessory material, and the proglumide is slightly soluble in water but is solution in an alkaline solution. By virtue of the alkaline accessory material, various quality indexes of a finished product are kept basically stable within a valid period, and moreover the dissolution rate of the product is improved. The calcium hydrogen phosphate, which serves an accessory material, can accelerate disintegration of the finished product while addition of a disintegrating agent, so that cost of the finished product can be reduced.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an anti-acid and anti-ulcer disease proglumide pharmaceutical composition. Background technique [0002] Proglumide has a better effect on controlling gastric acid and inhibiting the secretion of pepsin, and has protective and healing effects on gastric mucosa, and can be used to treat gastric ulcer, duodenal ulcer, gastritis and other peptic ulcers. Although there are many kinds of proglumide tablets on the market, its main component, proglumide, is a white crystalline powder, odorless and slightly bitter. This product is easily soluble in ethanol or chloroform, slightly soluble in water, and soluble in sodium hydroxide test solution. In the past, the ingredients of excipients were mainly dextrin, starch, etc., but due to different excipients and different preparation processes, there were shortcomings such as short storage time and low dissolution rate of drugs. Co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/02A61K31/197A61P1/04
Inventor 曾培安胡良红吴健民张静
Owner KAMP PHARMA
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