Method for improving dissolution rate of cefquinome sulfate and method for detecting dissolution rate of cefquinome sulfate

Abstract

The invention discloses a method for improving the dissolution rate of cefquinome sulfate and a method for detecting the dissolution rate of the cefquinome sulfate. The method comprises the followingsteps of 1) mixing soybean oil for injection and ethyl oleate according to a ratio of 5: 5, heating mixed liquid to 120 DEG C under the protection of N2, keeping the temperature for 2 hours, and cooling the liquid to the room temperature; 2) heating the mixed liquid to 60 DEG C, adding BHT, performing stirring and melting, adding hydrogenated castor oil and span 60 when the liquid is cooled to 40DEG C, performing stirring for 30 minutes, and performing cooling to the room temperature; and 3) adding a prescription amount of the cefquinome sulfate after all medicinal auxiliary materials are added, pouring the cefquinome sulfate into a colloid mill, and performing grinding for 5-20 minutes in a manner of alternating circulating grinding and non-circulating grinding. The particle size of thecefquinome sulfate is changed through the colloid mill, so that the drug dissolution rate of the cefquinome sulfate is increased; and through particle size detection and dissolution rate analysis, after grinding is conducted for 15-20 min, the cefquinome sulfate with the particle size of 10 microns or below accounts for 80%, and the dissolution rate is the best.

Description

Technical field [0001] The invention belongs to the technical field of chemical pharmaceutical preparations, and particularly relates to a method for improving the dissolution rate of cefquinome sulfate and a method for detecting the dissolution rate. Background technique [0002] Cefquinome, also known as Cefquine and Cefquinome, is a fourth-generation cephalosporin antibiotic for animals developed by Hoechst Animal Health Products Company in Germany. It was first approved for marketing in 1993 and Interveil International in 1994 The limited company also went public. The cephalosporin nucleus of cefquin sulfate bricks-7-aminocephalosporanic acid (7-ACA) is an essential group for antibacterial activity. The difference from the third generation cephalosporins is that the nucleus has a quaternary ammonium salt group. . Cefquinome is a zwitterion, the cephalosporin nucleus is negatively charged, and the quaternary quaternary saddle ion group is positively charged. The chemical str...

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Problems solved by technology

[0005] The present invention provides a kind of use colloid mill to change cefquinome sulfate particle size in order to solve the defects and deficiencies in the above-mentioned prior art, improve its drug dissolution rate, solve the problem that cefquinome sulfate dissolution rate is low, and After particle size detection and dissolution analysis, it is concluded that after grinding by colloid mill for 15-20 minutes, the particle size distribution below 10 μm accounts for 80%, and the dissolution rate is the best method for improving the dissolution rate of cefquinome sulfate and its dissolution rate. Detection method

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