Preparation method for microcrystalline cellulose capable of increasing drug dissolution rate

A microcrystalline cellulose and dissolution technology, applied in the pharmaceutical field, can solve the problems of partial bottom line, fluctuation of drug dissolution, unqualified, etc., and achieve the effect of eliminating influence, simple production operation and less waste residue.

Active Publication Date: 2017-04-26
QUFU TIANLI MEDICAL SUPPLEMENTS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for some poorly soluble drugs such as simvastatin, domperidone, etc., in the process of using microcrystalline cellulose, there will often be fluctuations in the dissolution rate of the drug, partial bottom line or even unqualified phenomena.

Method used

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  • Preparation method for microcrystalline cellulose capable of increasing drug dissolution rate
  • Preparation method for microcrystalline cellulose capable of increasing drug dissolution rate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1. Put 300 parts of water in the reaction kettle, add 9.5 parts of hydrochloric acid, detect the acid concentration as 0.30mol / L, turn on the steam and heat to 72°C, close the intake valve, start stirring, and put 100 parts of refined cotton cut into small slices Put it into the reaction kettle, after feeding, open the steam valve to raise the temperature to 100°C, and react for 42 minutes.

[0023] 2. Dilute and stratify: Put 560 parts of water in the storage tank, put the material after the above reaction into the storage tank, stir well and let it stand for 2 hours to make the material stratify.

[0024] 3. Centrifugal washing: extract the upper 1 / 2 slurry of the material part after standing still and enter it into centrifugal washing. After the slurry is dried, wash it with reverse osmosis water until the pH value of the water flowing out of the centrifuge outlet is 7, and stop washing. Continue to centrifuge and dry to obtain material A, and the remaining lower lay...

Embodiment 2

[0028] 1. Put 300 parts of water in the reaction kettle, add 10 parts of hydrochloric acid, check the acid concentration to be 0.31mol / L, turn on steam and heat to 70°C, close the intake valve, start stirring, and put 100 parts of refined cotton cut into small slices Put it into the reaction kettle, after feeding, open the steam valve to raise the temperature to 100°C, and react for 40 minutes.

[0029] 2. Dilution and stratification: Put 570 parts of water in the storage tank, put the materials that have completed the above reaction into the storage tank, stir them and let stand for 4 hours to make the materials layered.

[0030] 3. Centrifugal washing: extract the upper 3 / 4 slurry of the material part after standing still and enter it into centrifugal washing. After the slurry is dried, wash it with reverse osmosis water until the pH value of the water flowing out of the centrifuge outlet is 7, and stop washing. Continue to centrifuge and dry to obtain material A, and the re...

Embodiment 3

[0034] 1. Put 300 parts of water in the reaction kettle, add 11.2 parts of hydrochloric acid, check the acid concentration to be 0.35mol / L, turn on steam and heat to 69°C, close the intake valve, start stirring, and put 100 parts of refined cotton cut into small slices Put it into the reaction kettle, after feeding, open the steam valve to raise the temperature to 100°C, and react for 37 minutes.

[0035] 2. Dilution and stratification: put 580 parts of water in the storage tank, put the material after the above reaction into the storage tank, stir well and let it stand for 3 hours to make the material stratify.

[0036] 3. Centrifugal washing: extract the upper 1 / 4 slurry of the material part after standing to enter the centrifugal washing, after the slurry is dried, wash with reverse osmosis water until the pH value of the water flowing out of the centrifuge outlet is 7, stop washing, Continue to centrifuge and dry to obtain material A, and the remaining lower layer material...

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Abstract

The invention discloses a preparation method for microcrystalline cellulose capable of increasing the drug dissolution rate and belongs to the technical field of pharmacy. The preparation method for the microcrystalline cellulose capable of increasing the drug dissolution rate comprises the following steps that raw materials are put into a reaction still containing acid liquor, a steam valve is opened to heat up, and a temperature reaction is maintained; water is added into a storage tank, materials after the reaction in step (1) are added into the storage tank, and still standing is conducted after even stirring to enable the materials to be layered; the upper layer thick liquid of the material part after still standing is extracted for 1 / 4-3 / 4 and then subjected to centrifugal washing, after the thick liquid is spin-dried and washed till the pH value of water outflowing from an water outlet of a centrifugal machine is 6-7, washing is stopped, centrifuge dripping is continuous, and a material A is obtained; the material A after centrifuge dripping is dried, the dried material A is obtained; and pulverizing and sieving are conducted, specifically, the dried material A obtained from the last step is evenly added into a pulverizer to be pulverized, and microcrystalline cellulose A, namely microcrystalline cellulose capable of improving the drug dissolution rate, is prepared after pulverizing and sieving. According to the preparation method for the microcrystalline cellulose capable of increasing the drug dissolution rate, the defect that the dissolution rate of traditional microcrystalline cellulose for an indissolvable drug is low and unstable is overcome.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and more specifically relates to the preparation of microcrystalline cellulose for improving drug dissolution. Background technique [0002] Microcrystalline cellulose is a hydrolyzed product of natural cellulose, with a white or off-white appearance. It is a crystalline powder product, insoluble in water, stable in nature, and does not chemically react with the main drug. As a filler, it can be used in a proper amount in the prescription, which can make the prepared particles loose, uniform and fine, and have good binding performance. At the same time, it is also a good disintegrant because it can rapidly expand the tablet and disintegrate after absorbing water. [0003] In the pharmaceutical industry, microcrystalline cellulose is widely used in pharmaceutical preparations, and microcrystalline cellulose is often used as an adsorbent, suspending agent, diluent, and disintegrating agent. In r...

Claims

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Application Information

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IPC IPC(8): C08B15/02
CPCC08B15/02
Inventor 夏叶青毕勇刘强任利亭
Owner QUFU TIANLI MEDICAL SUPPLEMENTS CO LTD
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