The invention provides an ink-jet printing machine sprayer cleaning device and a control method thereof. The cleaning device comprises a first adaptive pipe connector, a second adaptive pipe connector, a third adaptive pipe connector, a fourth adaptive pipe connector, a cleaning solution filter, a pump, a backpressure pipe, an air filter, an air pressure switch, an atomizing nozzle, a cleaning solution tank, a first liquidometer, a collection groove, a waste solution recycling tank, a second liquidometer and a control device. By arranging the different adaptive pipe connectors, the ink-jet printing machine sprayer cleaning device can be suitable for different factories to produce ink-jet printing machines, universality is high, printing machine sprayers and other components are automatically washed, the washing process is conducted in a closed mode, waste cleaning solutions are automatically collected, generated waste liquid is little, manual work is not needed, and safety and high efficiency are achieved.