The invention relates to a crosslinkable, radiation-resistant, highly-flame-retardant, low-smoke, zero-halogen cable material and a preparation method of the cable material. The cable material comprises the following raw materials by weight parts of 5 to 30 parts of high density polyethylene, 20 to 60 parts of a polyolefin elastomer, 5 to 20 parts of modified ethylene-propylene diene copolymer, 160 to 200 parts of flame retardant masterbatches, 3 to 8 parts of a first antioxidant, 0 to 5 parts of a light stabilizer, 1 to 5 parts of a first lubricating agent, and 1.5 to 6 parts of a crosslinking sensitizer. The cable material provided by the invention can be used for the fields of electric wires and cables in the nuclear power industry, communication cables and sheathes in a space technology, irradiation disinfection products of medical instruments, and the like by adding the flame retardant masterbatches in combination with the high-efficiency antioxidant and radiation-resistant resin without additionally adding any anti-radiation agent. The preparation method of the crosslinkable, radiation-resistant, highly-flame-retardant, low-smoke and zero-halogen cable material provided by the invention has the advantages of being simple in process, easy to operate and low in cost.