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Pitavastatin calcium composition

A technology of pitavastatin calcium and a composition is applied in the field of preparation compositions containing pitavastatin calcium tablets, and can solve the problems of uneven content between tablets, low dissolution rate of pitavastatin calcium tablets, etc.

Inactive Publication Date: 2016-01-06
DISHA PHARMA GRP
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to solve the problem of low dissolution rate of pita

Method used

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Abstract

The invention relates to a preparation composition containing pitavastatin calcium tablets, and belongs to the technical field of medicines. The technical scheme is that 1000 tablets of the preparation composition comprise 1-2 g of pitavastatin calcium of which the D90 is 25 [mu]m, 30-70 g of lactose, 10-60 g of microcrystalline cellulose, 8-15 g of mannitol, 3.0-16 g of low substituted hydroxypropyl cellulose, 0.15-0.5 g of sodium carboxymethyl cellulose and 0.5-1.0 g of magnesium stearate. According to the technical scheme, through the addition of mannitol and reasonable control of the granularity, the problems of relatively low dissolvability and nonuniform content of the tablets are solved.

Description

technical field [0001] The invention relates to a preparation composition containing pitavastatin calcium tablets, belonging to the technical field of medicine. Background technique [0002] Pitavastatin Calcium Tablets is a third-generation statin drug jointly developed by Nissan Chemical Industry Co., Ltd. and Kowa Co., Ltd. It was registered in Japan in November 1999 and was first approved for marketing in Japan on July 17, 2003. . It is mainly applicable to the treatment of hyperlipidemia and familial hypercholesterolemia. [0003] Pitavastatin calcium is insoluble in water, so pitavastatin calcium tablets have problems of low stability and dissolution rate. Using the prescription and preparation process involved in this article can effectively improve the stability of pitavastatin calcium and improve the dissolution rate, which is beneficial to Industrialized mass production. [0004] The commercial specifications of pitavastatin calcium are 1 mg and 2 mg. During the...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/47A61K47/26A61P3/06
Inventor 梁君付玉麦邹元华
Owner DISHA PHARMA GRP
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