Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cefixime submicro-emulsion solid preparation and novel application thereof

A technology for cefixime and solid preparation, applied in the field of medicine, can solve the problems of poor stability and low dissolution rate, and achieve the effects of low cost, increased solubility and improved therapeutic index

Inactive Publication Date: 2011-05-04
HAINAN MEIDA PHARMA
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to provide a kind of cefixime submicroemulsion solid preparation and its new application, specifically, the solid preparation of cefixime through microemulsification treatment and its new application, well solve the problem of cefixime currently on the market. The problem of poor stability and low dissolution rate of gramoxime solid preparations, and it can also be used to prepare medicines for treating acute furunculosis in children, and satisfactory technical results have been obtained

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cefixime submicro-emulsion solid preparation and novel application thereof
  • Cefixime submicro-emulsion solid preparation and novel application thereof
  • Cefixime submicro-emulsion solid preparation and novel application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 cefixime submicron emulsion particles

[0029] Add 160.7g of soybean lecithin, 89.3g of poloxamer 188 and 80g of sodium deoxycholate into 2500ml of water for injection, then add 100g of cefixime and mix evenly, heat and stir in a water bath at 86°C until it melts, and use a tissue masher Shearing and stirring for 20min, rotating speed 12000r / min, to obtain the primary emulsion, and then emulsifying 5 times through a high-pressure homogenizer cycle to obtain an emulsion, then freeze-drying in a large plate, pulverizing, and obtaining 396.6g of submicron emulsion particles of cefixime, yield 92.2%.

Embodiment 2

[0030] The preparation of embodiment 2 cefixime submicron emulsion particles

[0031] Add 642.9g of soybean lecithin, 357.1g of poloxamer 188 and 500g of sodium deoxycholate into 9000ml of water for injection, then add 100g of cefixime and mix evenly, heat and stir in a 75°C water bath until it melts, and use a tissue masher Shearing and stirring for 15 minutes, rotating speed 13000r / min, to obtain the primary emulsion, and then cyclic emulsification by a high-pressure homogenizer for 5 times to obtain an emulsion, and then spray drying to obtain 1467g of submicron emulsion particles of cefixime, with a yield of 91.7%.

Embodiment 3

[0032] The preparation of embodiment 3 cefixime tablets

[0033] 44.2g cefixime submicroemulsion granules, 56g pregelatinized starch, 70g lactose and 9g low-substituted hydroxypropyl cellulose prepared in Example 1 were passed through 80 mesh sieve respectively, then mixed uniformly, and 8% povidone K was added 30 30ml of 70% ethanol solution was used to make soft materials, granulated with a 20-mesh sieve, dried at 55°C, granulated with a 20-mesh sieve, added 1.8g of magnesium stearate, mixed evenly, and compressed into tablets to obtain cefixime tablets.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a cefixime submicro-emulsion solid preparation and a novel application thereof, in particular to a solid preparation of cefixime processed by micro-emulsification and a novel application thereof. The cefixime submicro-emulsion solid preparation comprises cefixime, an emulsifying agent and an emulsifying aid agent, wherein the active component of the cefixime is processed by applying a micro-emulsification technology. The stability is enhanced, the solubility is increased, and the problem of low leaching degree is solved.

Description

technical field [0001] The invention relates to a cefixime submicroemulsion solid preparation and its new application, in particular to a microemulsified cefixime solid preparation and its new application, belonging to the technical field of medicine. Background technique [0002] Furuncle is an acute purulent infection of a single hair follicle and its associated sebaceous glands caused by bacterial invasion from the hair follicle or sweat gland. A single person is called furunculosis, and those who repeatedly send out are called furunculosis. The disease is more common in the hot season, often in the head, face, neck, armpits and buttocks and other parts that are often subject to friction. It is common in malnourished children or diabetic patients. Initially, it was an inflammatory papule similar to hair follicles, and gradually increased to pink or dark red infiltrating nodules, with pain and tenderness. After 2-3 days, the nodules purulent, necrotic, and softened, form...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K9/20A61K9/48A61K9/00A61K31/546A61K47/42A61K47/38A61K47/36A61K47/34A61K47/32A61P31/04A61P17/02A61K47/10A61K47/18
Inventor 陶灵刚
Owner HAINAN MEIDA PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com