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Danazol tablet composition

A composition, the technology of danazol, which is applied in the field of pharmaceutical preparations, can solve problems such as dissolution rate not up to standard, and achieve a smooth appearance

Inactive Publication Date: 2018-11-13
WEIHAI GUANBIAO INFORMATION TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the technical scheme of the present invention, the addition of lecithin solves the problem of tablet capping; the rational compatibility of sodium lauryl sulfate, low-substituted hydroxypropyl methylcellulose, and sodium carboxymethyl starch solves the problem that the dissolution rate does not meet the standard. question

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1. Danazol 100g, lecithin 1.4g, sodium lauryl sulfate 1.2g, lactose 36g, low-substituted hydroxypropyl methylcellulose 8g, sodium carboxymethyl starch 4g, magnesium stearate 1.0g . Prepare 1000 tablets according to the preparation method described in the technical scheme.

Embodiment 2

[0016] Example 2. Danazol 100g, lecithin 2.6g, sodium lauryl sulfate 1.8g, lactose 64g, low-substituted hydroxypropyl methylcellulose 15g, sodium carboxymethyl starch 8g, magnesium stearate 1.8g . Prepare 1000 tablets according to the preparation method described in the technical scheme.

Embodiment 3

[0017] Example 3. Danazol 100g, lecithin 1.8g, sodium lauryl sulfate 1.5g, lactose 52g, low-substituted hydroxypropyl methylcellulose 12g, sodium carboxymethyl starch 6g, magnesium stearate 1.5g . Prepare 1000 tablets according to the preparation method described in the technical scheme.

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PUM

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Abstract

The invention relates to a danazol tablet composition, and belongs to the technical field of medicine preparations. The danazol tablet composition in a unit dose comprises 100 mg of danazol, 1.4-2.6 mg of lecithin, 1.2-1.8 mg of sodium lauryl sulfate, 36-64 mg of lactose, 8-15 mg of low-substituted hydroxypropyl methyl celluloses, 4-8 mg of sodium carboxymethyl starch and 1.0-1.8 mg of magnesium stearate. The danazol tablet composition has the advantage that the clinical requirements can be met by the danazol tablet composition.

Description

technical field [0001] The invention relates to a danazol tablet composition and belongs to the technical field of pharmaceutical preparations. Background technique [0002] Danazol, also known as Danazol, Anconazole, Ethyl Testosterol, Ethyl Androstenazole, chemical name 17α-pregna-2,4-diene-20-alkyno[2,3-d]isox Azol-17β alcohol has weak androgenic activity, and has protein assimilation and anti-estrogen effects. It belongs to gonadotropin inhibitors and is used clinically to treat endometriosis, fibrocystic breast disease, and hereditary vascular disease. Edema, gynecomastia, precocious puberty, thrombocytopenic purpura, hemophilia and lupus erythematosus, etc. [0003] The specification of danazol tablet is 100 mg, which is an insoluble drug and has poor compressibility. Firstly, the dissolution rate of the prepared tablet is not up to the standard, and secondly, capping is prone to occur. Contents of the invention [0004] Aiming at the deficiencies of the prior art...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/24A61K47/20A61K47/38A61K47/36A61K31/58A61P5/26A61P5/32A61P15/00A61P15/14A61P7/10A61P5/24A61P7/04A61P37/02
CPCA61K9/2013A61K9/2054A61K9/2059A61K31/58A61P5/24A61P5/26A61P5/32A61P7/04A61P7/10A61P15/00A61P15/14A61P37/02
Inventor 孙爱梅
Owner WEIHAI GUANBIAO INFORMATION TECH
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