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Pomelo flavedo fresh-product lozenge and preparation method thereof

A technology for transforming tangerine red into fresh and tangerine red, which is applied in the field of tangerine red fresh lozenges and their preparation, can solve the problems of loss of effective components, influence on the exertion of medicinal effect, incomplete extraction and the like, and achieves low production cost and good product stability. , the effect of the simple method

Inactive Publication Date: 2019-06-25
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the defects or deficiencies in the production of Huajuhong products in the prior art that the active ingredients are lost, incompletely extracted, and affect the efficacy of the drug, and provide a Huajuhong fresh product buccal tablet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] This embodiment provides a Huajuhong fresh product buccal tablet, and its formula is as follows: 165 g of dried Huajuhong fresh peel (fresh peel: 275 g), 4.2 g of gum arabic, 30 g of polyvinylpyrrolidone, and 389.4 g of mannitol (inner Plus 68 g, plus 321.4 g), sucralose 3.4 g, steviol glycosides 2 g, menthol 1.5 g, magnesium stearate 4.5 g.

[0044] Its preparation method is as follows:

[0045] S1: Wash and purify the orange-red fresh peel with water, peel and cut into small pieces, sterilize, add gum arabic and water to the peel, perform mechanical beating, and centrifuge;

[0046] S2: Add polyvinylpyrrolidone and mannitol (internal addition) to the orange-red precipitate treated in step S1, mix well, freeze-dry with the supernatant separately, pulverize and combine to obtain orange-red granules, add mannitol (external addition), Menthol, sucralose, steviol glycosides and magnesium stearate, blended;

[0047] S3: The above materials are directly compressed into tab...

Embodiment 2

[0049] This example provides a kind of Huajuhong fresh product buccal tablet, its formula is as follows: 165 g of dried Huajuhong fresh peel (fresh peel: 275 g), 6.6 g of gum arabic, 25 g of polyvinylpyrrolidone, 5 g of copovidone, Mannitol 359.7g (77.7g inside, 282g outside), xylitol 30g (10g inside, 20g outside), sucralose 2g, steviol glycoside 0.5g, mogroside 0.5g, menthol 1.4g, Magnesium stearate 4.3 g.

[0050] Its preparation method is as follows:

[0051] S1: Wash and purify the orange-red fresh peel with water, peel and cut into small pieces, sterilize, add gum arabic and water to the peel, perform mechanical beating, and centrifuge;

[0052] S2: Add polyvinylpyrrolidone, copovidone, xylitol (internal addition) and mannitol (internal addition) to the orange-red precipitate treated in step S1, mix well, and freeze-dry the supernatant separately, pulverize and combine to obtain For Huajuhong Granules, add mannitol (external), xylitol (external), menthol, sucralose, ste...

Embodiment 3

[0055] This example provides a kind of Huajuhong fresh product buccal tablet, and its formula is as follows: 165 g of dried Huajuhong fresh peel (fresh peel: 275 g), 9 g of gum arabic, 4 g of hydroxypropyl methylcellulose, copolydimensional Ketone 2 g, sorbitol 380.8 g (96 g inside, 284.8 g outside), xylitol 26 g (6 g inside, 20 g outside), sucralose 5 g, steviol glycoside 2.8 g, menthol 1.2 g, Magnesium stearate 4.2 g.

[0056] Its preparation method is as follows:

[0057] S1: Wash and purify the orange-red fresh peel with water, peel and cut into small pieces, sterilize, add gum arabic and water to the peel, perform mechanical beating, and centrifuge;

[0058]S2: Add hydroxypropyl methylcellulose, copovidone, sorbitol (internal addition) and xylitol (internal addition) to the orange-red precipitate treated in step S1, mix well, and freeze separately with the supernatant Dry, pulverize and combine to obtain Huajuhong granules, add sorbitol (additional), xylitol (additional...

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PUM

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Abstract

The invention relates to a pomelo flavedo fresh-product lozenge and a preparation method thereof. The pomelo flavedo fresh-product lozenge is composed of the following components by mass fraction: 25-30% of a dried fresh pomelo flavedo peel product, 0.7-1.5% of Arabic gum, 1-5%of an adhesive, 61-72% of a filler, 0.1-0.6% of menthol, 0.7-1% of magnesium stearate, and 0.5-1.3% of a sweetener. The preparation method adopts Arabic gum as an emulsifier and a binder, and can emulsify the volatile oil in the pomelo flavedo, so that the active ingredient is not destroyed and lost, and the efficacy ofthe pomelo flavedo can be fully exerted; The addition of the binder can promote the tableting; and the addition of a sweetener can alleviate the bitterness of the pomelo flavedo and the taste is good.The lozenge has good stability through the cooperation of the components, and can fully protect the active ingredient of the pomelo flavedo to fully exert the pharmacological effect.

Description

technical field [0001] The invention belongs to the field of food and biomedicine, and in particular relates to a Huajuhong fresh buccal tablet and a preparation method thereof. Background technique [0002] Huajuhong, also known as Huazhoujuhong, is the immature or mature dry outer peel of Huazhou pomelo or pomelo, a citrus plant in the genus Rutaceae. As a food and medicinal material, Huajuhong has a long history. It is reported that it was in the Song Dynasty Since then, it has been used as medicine to treat symptoms such as wind-cold cough, itchy throat with excessive phlegm, and accumulation of heat. The main active ingredients of Huajuhong are polysaccharides, volatile oils, flavonoids, etc. At present, most of Huajuhong’s products are processed from Huajuhong extract except for the hard orange-red tires that are dried from tender fruits. After these products are processed by heating and extraction, some active ingredients are easily oxidized and lost, and may even ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/00A61K36/752A61K9/20A61K47/36A61P11/14A61P11/04A61P11/10A61P1/14A61P31/04A61P35/00A61P11/06A61K131/00
Inventor 余楚钦邓善滨杜孟姣林华庆陈莉诗余嘉贤
Owner GUANGDONG PHARMA UNIV
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